Results 161 to 170 of about 125,120 (264)

Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health. [PDF]

Front Physiol
Kumar V, Greenberg ML.
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes. [PDF]

J Biol Chem
Atser MG, Wenyonu CD, Rowe EM, Leung CLK, Cen HH, Queathem ED, Liu LT, Moravcova R, Rogalski J, Perrin D, Crawford P, Foster LJ, Alcazar A, Johnson JD.   +13 more
europepmc   +1 more source

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

Integrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng, Lu Wang, Runhan Li, Wenkai Lai, Chongkui Sun, Jianguo Cui, Bicheng Zhu, Jiang Zhang   +7 more
wiley   +1 more source

The pyruvate dehydrogenase complex in concert with the DNA/RNA-binding protein YBX1 regulates cell senescence and tumorigenesis. [PDF]

J Biol Chem
Chen H, Shi J, Wang Q, Liang K, Pei S, Zhang Y, Shi X, Lv J, Xia T, Chen D, Ma Y, Liu HX, Piao HL.   +12 more
europepmc   +1 more source

Pyruvate Dehydrogenase Deficiency [PDF]

, 2020
openaire   +1 more source

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source

Molecular architecture of mammalian pyruvate dehydrogenase complex. [PDF]

Protein Cell
Chen M, Song Y, Zhang S, Zhang Y, Chen X, Zhang M, Han M, Gao X, Li S, Yang M.   +9 more
europepmc   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia. [PDF]

JCI Insight
Yap JQ, Nikouee A, Kim M, Cao Q, Rademacher DJ, Lau JE, Arora A, Zou LY, Sun Y, Szweda L, Sadek H, Elliot S, Roos B, Glassberg MK, Ji HL, Gao X, Dong Q, Zang QS.   +17 more
europepmc   +1 more source