Results 171 to 180 of about 124,495 (263)

Pyruvate Dehydrogenase Kinase 4 Underlies the Metabolic Disorder of Cardiomyocytes in Patients With Hypertrophic Cardiomyopathy From Hypertrophy to Heart Failure. [PDF]

J Am Heart Assoc
Hua X, Sun Z, Wang C, Cui H, Shan D, Tao M, Cui Z, Chang Y, Bao M, Mo H, Chen X, Song J.   +11 more
europepmc   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis. [PDF]

Nat Commun
Wang C, Ma C, Xu Y, Chang S, Wu H, Yan C, Chen J, Wu Y, An S, Xu J, Han Q, Jiang Y, Jiang Z, Chu X, Gao H, Zhang X, Chang Y.   +16 more
europepmc   +1 more source

Pyruvate Dehydrogenase Deficiency [PDF]

, 2020
openaire   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

A missense mutation in PDHB gene: identification of the patient with pyruvate dehydrogenase deficiency and demonstration of pathogenicity in vitro. [PDF]

Ital J Pediatr
Li Y, Cheng L, Li X, Liu J, Yi L, Bo T.
europepmc   +1 more source

Lactate Dehydrogenase A and a Novel Four‐Gene Signature as Dual Diagnostic Markers for Lung Adenocarcinoma and Ischemic Stroke

Medicine Advances, EarlyView.
This study identified shared molecular alterations between lung adenocarcinoma (LUAD) and ischemic stroke (IS) through integrative transcriptomic analysis of TCGA‐LUAD and GSE146882 datasets, revealing a four‐gene diagnostic signature (LDHA, NME4, SLC25A39, and SLC7A5) with high accuracy across both diseases. Among these, LDHA was further identified as
Jin Xie, Gao‐Chun Xiao, Xin‐Yang Qu, Rui‐Min Wu, Yu‐Long Zou, Xue Hu, Xu‐Sheng Liu   +6 more
wiley   +1 more source

Stoichiometry and architecture of the human pyruvate dehydrogenase complex. [PDF]

Sci Adv
Zdanowicz R, Afanasyev P, Pruška A, Harrison JA, Giese C, Boehringer D, Leitner A, Zenobi R, Glockshuber R.   +8 more
europepmc   +1 more source

Hemodynamic Modeling and Phase‐Adjustable Reconstruction of Hyperpolarized Cardiac 13C MRS Using 1H Cine and ECG Timing

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To deconvolve cardiac phase and hemodynamic effects in hyperpolarized (HP) [1‐13C]pyruvate and to develop a cardiac phase‐adjustable reconstruction framework. Methods Cardiac phase drift during dynamic acquisition of HP 13C MRS and its effect on dynamic signal fidelity were simulated using a digital cardiac phantom. A hemodynamic model
Sung‐Han Lin, Corey Mozingo, Crystal E. Harrison, Kelley A. Derner, Craig R. Malloy, Jae Mo Park   +5 more
wiley   +1 more source

Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response. [PDF]

Cell Rep
Chen CY, Shao Z, Wang G, Zhao B, Hardtke HA, Leong J, Zhou T, Zhang YJ, Qiao H.   +8 more
europepmc   +1 more source