Results 191 to 200 of about 125,120 (264)

Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth. [PDF]

Nat Commun
Jia Y, Wang S, Urban S, Müller JM, Sum M, Wang Q, Bauer H, Schulte U, Rampelt H, Pfanner N, Schüle KM, Imhof A, Forné I, Berlin C, Sigle A, Gratzke C, Greschik H, Metzger E, Schüle R.   +18 more
europepmc   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease. [PDF]

iScience
Guo B, Zhang F, Yin Y, Ning X, Zhang Z, Meng Q, Yang Z, Jiang W, Liu M, Wang Y, Sun L, Yu L, Mu N.   +12 more
europepmc   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Understanding the Role of Pyruvate Dehydrogenase Kinase 3 in Gynecological Cancers

Bairy M, Shaheeda A, Suresh PS, Mascarenhas R, Kabekkodu SP.   +4 more
europepmc   +1 more source

Pyruvate dehydrogenase alleviates macrophage autophagy in Hcy-induced ApoE ^-/- mice. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Liu Q, Li F, Hu S, Ding N, Ma F, Hao Y, Li G, Xiong J, Zhang H, Jiang Y.   +9 more
europepmc   +1 more source

Body size of male Atlantic salmon (Salmo salar L.) at introduction of a 5‐week LD12:12 winter signal influences their decision to mature early or smoltify

Journal of Fish Biology, EarlyView.
Abstract Sexual maturation of male Atlantic salmon post‐smolts (‘jacking’) is undesired in aquaculture and seems to occur due to the intensification in modern facilities. Maturation depends on internal and external factors (temperature, photoperiod, feed availability, energy levels, body size, genetic background) that act on the brain‐pituitary‐gonad ...
Enrique Pino‐Martinez, Kristine F. Staveland, Mitchell S. Fleming, Pablo Balseiro, Cindy Pedrosa, Sigurd O. Handeland   +5 more
wiley   +1 more source

Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1). [PDF]

J Biol Chem
Liang Z, Ralph-Epps T, Schmidtke MW, Kumar V, Greenberg ML.   +4 more
europepmc   +1 more source

High‐throughput multispecies quantitative polymerase chain reaction assays to study the effects of acute thermal stress in three species of Acipenser sturgeon

Journal of Fish Biology, EarlyView.
Abstract Fishes experience thermal stress in their natural environment that can be caused by natural or anthropogenic factors and can directly affect their physiology. In this study, we developed a multispecies OpenArray™ qPCR (quantitative polymerase chain reaction) ‘chip’ to measure the effects of acute thermal stress on the mRNA response of ...
Hossein Haghighi, Kyle Madden, William S. Bugg, Faith M. Penny, Scott A. Pavey, Nicholas J. Bernier, Kenneth M. Jeffries   +6 more
wiley   +1 more source

Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4. [PDF]

BMC Nephrol
Areloegbe SE, Atuma CL, Aturamu A, Ajadi IO, Adelekan OE, Ajadi MB, Akintayo CO, Omoruyi GO, Onyekweli SO, Anifowose OF, Amusa OA, Ajayi K, Oyewole PA, Adegoke TE, Olaniyi KS.   +14 more
europepmc   +1 more source