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Assays of Pyruvate Dehydrogenase Complex and Pyruvate Carboxylase Activity
2011Pyruvate dehydrogenase complex (PDC) and pyruvate carboxylase (PC) are mitochondrial enzymes that provide the initial steps of the two main alternatives for pyruvate metabolism: oxidative decarboxylation vs. anaplerotic carboxylation, gluconeogenesis, and glycerogenesis.
Douglas, Kerr +2 more
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Pyruvate dehydrogenase E1α deficiency
Journal of Inherited Metabolic Disease, 1992SummaryPyruvate dehydrogenase (PDH) deficiency has long been recognized as the most common defined cause of primary lactic acidosis in infancy and early childhood. More recently, it has also been described in patients with subacute/chronic neurodegenerative disease without significant metabolic acidosis.
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Pyruvate dehydrogenase phosphatase
1996Four classes of protein serine/threonine phosphatases have been identified in eukaryotic cells on the basis of substrate specificities and sensitivity to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are ...
L. J. Reed +3 more
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1987
Publisher Summary This chapter summarizes some aspects of the structural organization of the mammalian pyruvate dehydrogenase complex and the regulation of its activity by a phosphorylation–dephosphorylation cycle. Phosphorylation and concomitant inactivation of pyruvate dehydrogenase (E1) occurs on three serine residues in the α subunit.
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Publisher Summary This chapter summarizes some aspects of the structural organization of the mammalian pyruvate dehydrogenase complex and the regulation of its activity by a phosphorylation–dephosphorylation cycle. Phosphorylation and concomitant inactivation of pyruvate dehydrogenase (E1) occurs on three serine residues in the α subunit.
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Pyruvate Dehydrogenase Complex
1969Publisher Summary This chapter discusses the multienzyme pyruvate dehydrogenase complexes, with emphasis on their structure, function, and regulation. These complexes have been isolated from Escherichia coli and from animal tissues as functional units with molecular weights in the millions.
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Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
Biochimica Et Biophysica Acta: Reviews on Cancer, 2021Saleha Anwar +2 more
exaly
Anesthesia in pyruvate dehydrogenase deficiency
Pediatric Anesthesia, 2008Irina, Milojevic, Dusica, Simic
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MOBILITY OF THE PYRUVATE DEHYDROGENASE COMPONENT IN THE KIDNEY PYRUVATE DEHYDROGENASE COMPLEX
Annals of the New York Academy of Sciences, 1982Thomas E. Roche +2 more
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