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Assays of Pyruvate Dehydrogenase Complex and Pyruvate Carboxylase Activity
2011Pyruvate dehydrogenase complex (PDC) and pyruvate carboxylase (PC) are mitochondrial enzymes that provide the initial steps of the two main alternatives for pyruvate metabolism: oxidative decarboxylation vs. anaplerotic carboxylation, gluconeogenesis, and glycerogenesis.
Douglas, Kerr +2 more
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Pyruvate dehydrogenase phosphatase
1996Four classes of protein serine/threonine phosphatases have been identified in eukaryotic cells on the basis of substrate specificities and sensitivity to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are ...
L. J. Reed +3 more
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Pyruvate dehydrogenase E1α deficiency
Journal of Inherited Metabolic Disease, 1992SummaryPyruvate dehydrogenase (PDH) deficiency has long been recognized as the most common defined cause of primary lactic acidosis in infancy and early childhood. More recently, it has also been described in patients with subacute/chronic neurodegenerative disease without significant metabolic acidosis.
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1987
Publisher Summary This chapter summarizes some aspects of the structural organization of the mammalian pyruvate dehydrogenase complex and the regulation of its activity by a phosphorylation–dephosphorylation cycle. Phosphorylation and concomitant inactivation of pyruvate dehydrogenase (E1) occurs on three serine residues in the α subunit.
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Publisher Summary This chapter summarizes some aspects of the structural organization of the mammalian pyruvate dehydrogenase complex and the regulation of its activity by a phosphorylation–dephosphorylation cycle. Phosphorylation and concomitant inactivation of pyruvate dehydrogenase (E1) occurs on three serine residues in the α subunit.
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Pyruvate Dehydrogenase Complex
1969Publisher Summary This chapter discusses the multienzyme pyruvate dehydrogenase complexes, with emphasis on their structure, function, and regulation. These complexes have been isolated from Escherichia coli and from animal tissues as functional units with molecular weights in the millions.
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The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage
Cell Metabolism, 2021Zhiyu Zhao +2 more
exaly
Pyruvate dehydrogenase deficiencies
1980The extraordinary complexity of the pyruvate dehydrogenase complex (PDHC) is clearly documented in Chapter 12. PDHC contains three catalytic and two regulatory enzymes. It is subject to an intricate array of controls, including phosphorylation and dephosphorylation of the α-subunit of its thiamin-dependent component, end-product inhibition by NADH and ...
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Anesthesia in pyruvate dehydrogenase deficiency
Pediatric Anesthesia, 2008Irina, Milojevic, Dusica, Simic
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