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A mimic of the pyruvate dehydrogenase complex
Bioorganic & Medicinal Chemistry Letters, 2010Pyruvic acid undergo decarboxylation catalyzed by a hydrophobic thiazolium salt and reacts with a hydrophobic analog of lipoic acid to form a hydrophobic acylthioester that reacts with aniline to form acetanilide in water, but only in the presence of a hydrophobically modified polyaziridine that acts to gather the reactants just as the enzyme complex ...
Huanyu, Zhao, Ronald, Breslow
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
The activity of mammalian pyruvate dehydrogenase complex (PDC) is regulated by a phosphorylation/dephosphorylation cycle. Dephosphorylation accompanied by activation is carried out by two genetically different isozymes of pyruvate dehydrogenase phosphatase, PDP1c and PDP2c.
Tatiana, Karpova +3 more
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The activity of mammalian pyruvate dehydrogenase complex (PDC) is regulated by a phosphorylation/dephosphorylation cycle. Dephosphorylation accompanied by activation is carried out by two genetically different isozymes of pyruvate dehydrogenase phosphatase, PDP1c and PDP2c.
Tatiana, Karpova +3 more
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Nature, 1975
OXIDATION of pyruvate in perfused rat heart is inhibited by diabetes and by oxidation of fatty acids and ketone bodies1. Enhanced release and oxidation of fatty acids from muscle glycerides may be an important factor in the effects of diabetes2–4. These effects on pyruvate oxidation have generally been attributed to inhibition of pyruvate dehydrogenase,
R H, Cooper, P J, Randle, R M, Denton
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OXIDATION of pyruvate in perfused rat heart is inhibited by diabetes and by oxidation of fatty acids and ketone bodies1. Enhanced release and oxidation of fatty acids from muscle glycerides may be an important factor in the effects of diabetes2–4. These effects on pyruvate oxidation have generally been attributed to inhibition of pyruvate dehydrogenase,
R H, Cooper, P J, Randle, R M, Denton
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Biochemistry, 1977
One sulfhydryl group per polypeptide chain of the pyruvate dehydrogenase component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli was selectively labeled with N-[P-(2-benzoxazoyl)phenyl]-maleimide (NBM), 4-dimethylamino-4-magnitude of-maleimidostilbene (NSM), and N-(4-dimethylamino-3,5-dinitrophenyl)maleimide (DDPM) in 0.05 M ...
N, Papadakis, G G, Hammes
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One sulfhydryl group per polypeptide chain of the pyruvate dehydrogenase component of the pyruvate dehydrogenase multienzyme complex from Escherichia coli was selectively labeled with N-[P-(2-benzoxazoyl)phenyl]-maleimide (NBM), 4-dimethylamino-4-magnitude of-maleimidostilbene (NSM), and N-(4-dimethylamino-3,5-dinitrophenyl)maleimide (DDPM) in 0.05 M ...
N, Papadakis, G G, Hammes
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Archives of Biochemistry and Biophysics, 1985
The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
T R, Mullinax +3 more
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The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
T R, Mullinax +3 more
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Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart
Molecular and Cellular Biochemistry, 1995Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
T C, Carter, H G, Coore
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Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable
Biochemical and Biophysical Research Communications, 1985Pyruvate inhibited pyruvate dehydrogenase kinase activity in mitochondria from adipose tissue, heart, brain and kidney of fed rats. Starvation for 24 h led to increased kinase activity in mitochondria from adipose tissue and heart but not from brain or kidney and to reduction of pyruvate inhibition of the enzyme from adipose tissue, heart and brain ...
D, Lyn, H G, Coore
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Complexities of the pyruvate dehydrogenase complex
Neurology, 1998If one were to throw a dart at the center of a biochemical chart for intermediary metabolism, it would land on acetyl-CoA. This metabolite is at the convergence of pyruvate, fatty acid, and ketone body metabolism. Condensation of acetyl-CoA with oxaloacetate forms citric acid, the entry point into the tricarboxylic acid cycle.
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Pyruvate Carboxylase and Pyruvate Dehydrogenase Deficiency
2014Pyruvate carboxylase and pyruvate dehydrogenase deficiency are the most common disorders in pyruvate metabolism and almost always affect the central nervous system. The severity and the clinical phenotypes vary, with a range from overwhelming neonatal lactic acidosis and early death to milder presentations.
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Hormonal regulation of pyruvate dehydrogenase
Metabolism, 1971Abstract Studies of fatty acid synthesis in rat epididymal adipose tissue have revealed that insulin accelerates the conversion of medium lactate or pyruvate or of endogenous glycogen to fatty acids. These effects appear to result from an increased conversion of pyruvate to CO2 and acetyl CoA in the presence of the hormone.
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