Results 121 to 130 of about 16,904 (180)

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Thiamine, gastrointestinal beriberi and acetylcholine signaling. [PDF]

Front Nutr
Overton E, Emelyanova A, Bunik VI.
europepmc   +1 more source

Exploring gene biomarkers and targeted drugs for ferroptosis and cuproptosis in osteosarcoma: A bioinformatic approach

Environmental Toxicology, Volume 40, Issue 6, Page 891-901, June 2025.
Abstract Osteosarcoma predominantly affects adolescents and young adults and is characterized as a malignant bone tumor. In recent decades, substantial advancements have been achieved in both diagnosing and treating osteosarcoma. Resulting in enhanced survival rates.
Yingnan Ji, Lv Liu, Yu Liu, Yudong Ma, Zhenhua Ji, Xiaodan Wu, Qi Zhu   +6 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges

Diabetes, Obesity and Metabolism, Volume 27, Issue S3, Page 31-47, June 2025.
Abstract Metformin, a synthetic biguanide, is widely used to manage type 2 diabetes, and is commonly prescribed in polycystic ovary syndrome (PCOS) to address insulin resistance and associated metabolic and reproductive disturbances. PCOS is characterised by hormonal imbalances such as hyperandrogenism and anovulation, metabolic abnormalities including
Saeede Saadati, Taitum Mason, Rasoul Godini, Eszter Vanky, Helena Teede, Aya Mousa   +5 more
wiley   +1 more source

Parkinson's disease and glucose metabolism impairment. [PDF]

Transl Neurodegener
Chen L, Wang C, Qin L, Zhang H.
europepmc   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration

Murray-Cors S, Owens M, Liew Y, Day M, Cairns W, Prokop A.   +5 more
europepmc   +1 more source

The Pathogenesis of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency. [PDF]

Biomolecules
Sharma S, McKenzie M.
europepmc   +1 more source

A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
During brain activation triggered by sensory stimulation, mental activity, or physical work, nonoxidative metabolism of glucose (CMRglc‐non‐ox, where subscripts ‐n and ‐a denote the rate in neurons and astrocytes, respectively) and glycogen are disproportionately upregulated compared with the cellular rates of oxidative metabolism of glucose (CMRglc‐ox)
Gerald A. Dienel, Douglas L. Rothman, Silvia Mangia   +2 more
wiley   +1 more source