Results 181 to 190 of about 42,696 (258)

The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment. [PDF]

Mol Metab
Bertinat R, Holyoak T, Gatica R, Jara N, González-Chavarría I, Westermeier F.   +5 more
europepmc   +1 more source

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities. [PDF]

Eur J Immunol
Henry ÓC, O'Neill LAJ.
europepmc   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Pyruvate dehydrogenase deficiency in a female due to a 4 base pair deletion in exon 10 of the E1α gene [PDF]

, 2017
Benelli, Chantal, Desguerre, Isabelle, Fouque, Françoise, Haenggell, Charles, Liebaers, Inge, Lissens, Willy, Marsac, Cécile, Meirleir, Linda De, Ponsot, Gérard, Seneca, Sara   +9 more
core  

Guanidinylation of the cold shock protein YB‐1: Molecular basis, structural changes and Notch‐3 receptor binding

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Posttranslational modifications of Y‐box binding protein (YB)‐1 are the prerequisite for its very different protein functions. Here, we investigate the underlying molecular mechanisms of YB‐1 guanidinylation and link increased serum urea levels as well as the activity of glycine amidinotransferase (GATM) with guanidinylation.
Anna Leitz, Batuhan Kav, Xiyang Liu, Hebah Fatafta, Vera Jankowski, Bastian Aggeler, Yingying Gao, Ina Verena Martin, Kristian Vogt, Rafael Kramann, Tammo Ostendorf, Thomas Rauen, Birgit Strodel, Ute Raffetseder   +13 more
wiley   +1 more source

Mitochondrial Dysfunction and Reduced TCA Cycle Metabolite Levels in Inflammatory Bowel Disease Patients. [PDF]

J Inflamm Res
Dudzińska E, Madro A, Sauer AK, Grabrucker AM, Strachecka A.   +4 more
europepmc   +1 more source

Effects of Induced Endotoxaemia on Global Cardiovascular, Oxygenation and Haematologic Variables and the Integrity of the Endothelial Glycocalyx in the Horse

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
The current study demonstrated characteristic and well‐documented early hyperdynamic changes in cardiovascular parameters accompanied by concurrent hypotension, increased pulse pressure variation, leucopenia, and hyperlactatemia consistent with acute endotoxaemia.
Stephan Neudeck, Philipp K. Sauter, Annette P. N. Kutter, Barbara Steblaj, Franz J. Söbbeler, Julia Reiners, Fritjof Freise, Alvaro. J. Gutiérrez Bautitsta, Sabine B. R. Kästner   +8 more
wiley   +1 more source

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, Volume 116, Issue 7, Page 1795-1806, July 2025.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source

SDH defective cancers: molecular mechanisms and treatment strategies. [PDF]

Cell Biol Toxicol
Wang J, Yuan T, Yang B, He Q, Zhu H.
europepmc   +1 more source