Results 191 to 200 of about 22,061 (226)

Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells. [PDF]

Front Cell Dev Biol
Landowski M, Hagimori R, Gogoi P, Shahi PK, Oikawa K, Bhute VJ, McLellan GJ, Ikeda S, Yamada KI, Pattnaik BR, Takimoto T, Ikeda A.   +11 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, Volume 13, Issue 33, 15 June 2026.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

In vivo assessment of the recovery of myocardial pyruvate dehydrogenase activity following a ketogenic diet. [PDF]

Cardiovasc Res
Chen J, Erfani Z, Elnwasany A, Al Nemri S, Park J, Huynh MT, Zaidi M, Harrison CE, Wen X, Szweda LI, Park JM.   +10 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Targeting Glycolytic Plasticity to Overcome Therapy Resistance in Cancer Stem Cells: Mechanisms and Clinical Perspectives. [PDF]

Cells
Huang J, Yang X, Li F, Li X, Wei H, Li M.   +5 more
europepmc   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Deficiency of the NAD(P)HX metabolic repair system: a treatable mitochondrial disease. [PDF]

Orphanet J Rare Dis
Xu C, Jin H, Li J, Liu Z, Zhang W, Zhou J, Duan R, Liu Y, Song M, Zhang Z, Li T, Shen D, Zou Y, Wang J, Li H, Jiang H, Fang F.   +16 more
europepmc   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Clinical Phenotype Comparison in Polish Patient Cohorts with and Without Molecular Diagnosis of Dystonia. [PDF]

J Clin Med
Milanowski L, Jurek M, Salińska A, Podwysocka A, Figura M, Szlufik S, Geremek M, Nowak J, Szczałuba K, Hoffman-Zacharska D, Koziorowski D.   +10 more
europepmc   +1 more source

MPC1 promotes the damage of human coronary endothelial cells in macrolide-resistant mycoplasma pneumoniae via inhibiting mitophagy. [PDF]

Front Pediatr
Fu Y, Li M, Chen Q, Ding R, Hu T, Wu Q, Peng S.   +6 more
europepmc   +1 more source