Results 181 to 190 of about 22,061 (226)

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review). [PDF]

Int J Mol Med
Chen L, Gao F, Mei Q, Li Y, Cai Q, Feng X.   +5 more
europepmc   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Succinylation in cancer immunotherapy: mechanisms, biomarkers, and therapeutic implications. [PDF]

Front Immunol
Xie P, Long MH, Liu ZQ, Wang J, Liao DH, Wang ZB.   +5 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, Volume 600, Issue 12, Page 1699-1716, June 2026.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

<i>Mycobacterium tuberculosis</i> partitions the Krebs cycle under iron starvation. [PDF]

Elife
Serafini A, Garza-Garcia A, Sorze D, de Carvalho LPS, Manganelli R.   +4 more
europepmc   +1 more source

Colchicine Inhibits Chemokine Production in Monosodium Urate–Stimulated Innate Immune Cells

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Objective Colchicine is a well‐established, widely available drug used to treat inflammatory diseases driven by the innate immune system, most notably gout. Although much research has focused on neutrophils, the first responders in a gout flare, monocytes and lymphocytes, also play critical roles in sustaining the inflammatory response.
Laura M. Merlo Pich, Titus Schlüter, Andrei Sarlea, Mihai G. Netea, Calin Popa, Leo A. B. Joosten   +5 more
wiley   +1 more source

Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease. [PDF]

Clin Sci (Lond)
Dikalova A, Dikalov S.
europepmc   +1 more source

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy. [PDF]

Transl Neurodegener
Qian L, Deng Y, Song M, Zhang Z, Cheng J, Zhu B, Wu M, Zhang H, Hu Y.   +8 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source