Results 1 to 10 of about 5,906 (214)

SIRT3 regulates PDHA1 acetylation in HUVECs to modulate inflammation and pyroptosis under clinorotation [PDF]

iScience
Summary: Microgravity-induced endothelial inflammation contributes to cardiovascular dysfunction in astronauts, but the metabolic mechanisms involved are not fully defined. Sirtuin-3 (SIRT3), a mitochondrial deacetylase, regulates cellular metabolism and
Min Jiang, Junjie Shao, Kun Lin, Lejian Lin, Shuai Yue, Haojie Yan, Jingjing Zhou, Shujin Shi, Xin Li, Ran Zhang   +9 more
doaj   +4 more sources

Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate [PDF]

Frontiers in Neuroscience, 2021
Background and Purpose: Neurodegenerative diseases are associated with metabolic disturbances. Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) is an essential component in the process of glucose metabolism, and its deficiency exists in various ...
Wen Zhou
exaly   +6 more sources

The potential impact of GLS and PDHA1 on tumor immunity and immunotherapy response in LUSC [PDF]

Frontiers in Genetics
BackgroundLung squamous cell carcinoma (LUSC), a therapeutically challenging non-small cell lung cancer (NSCLC) subtype with a poor prognosis, exhibits heterogeneous responses to immunotherapy.
Tianhe Ling, Tianhe Ling, Jiahui Wu, Ling Xiaohao, Ling Xiaohao   +4 more
doaj   +6 more sources

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation [PDF]

Nature Communications
Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect.
Lian-Xin Liu
exaly   +5 more sources

Astragaloside IV increases PDHA1 in mesenchymal stem cell exosomes to treat myocardial infarction [PDF]

Scientific Reports
Acute myocardial infarction (AMI) is a threat to health, with high morbidity and mortality, posing a challenge to the public health system. This study aimed to explore the efficacy and potential targets of Astragaloside IV (AS-IV) combined with ...
Sha Zhongxin, Chen Zhijie, Du Feng, Guo Mei Qin, Zhong Ya, Hu Jinxin, Wei Zhang, Yu Zhenqiu   +7 more
exaly   +4 more sources

Mitochondrial PDHA1 acetylation orchestrates lactate-dependent epigenetic reprogramming to promote fibrosis via NUAK2 [PDF]

Cellular and Molecular Life Sciences
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with few effective treatment options. While metabolic reprogramming has been associated with IPF, the precise mechanisms connecting mitochondrial metabolic dysfunction to ...
Yujie Wang, Guanglian Du, Jinjin Zhang, Nailiang Zhai, Weili Liu, Guohong Cao, Hongbo Li, Bo Liu, Huiling Yang, Changjun Lv, Xiaodong Song, Songzi Zhang   +11 more
doaj   +3 more sources

Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1–PD-L1 axis: a multi-omics and clinical validation study [PDF]

npj Precision Oncology
Sarcomas are aggressive, immunologically cold tumors with limited benefit from immune-checkpoint blockade (ICB). Through integrated multi-omics, functional, and clinical analyses, we identify pyruvate dehydrogenase alpha 1 (PDHA1)—a cuproptosis-linked ...
Haotian Qin, Tiantian Qi, Nan Yao, Weibei Sheng, Jinhao Deng, Junyu Qian, Deli Wang, Hui Zeng, Jian Weng, Jun Yang, Fei Yu   +10 more
doaj   +3 more sources

PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2 [PDF]

Cell Death Discovery
Cells that detach from the extracellular matrix (ECM) undergo various forms of cell death, including ferroptosis. Previous studies have demonstrated that prostate cancer (PCa) cells undergo ferroptosis following ECM detachment, and resistance to ...
Yukun Cong, Kang Chen, Yunjie Ju, Qingliu He, Chunyu Liu, Jiawei Chen, Fang Lv, Jinyu Chen, Haoran Li, Liang Chen, Yarong Song   +10 more
doaj   +4 more sources

PIK-III-Mediated Elevation of Thiamine Re-Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1. [PDF]

Cell Prolif
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Xie D, Wang Y, Cheng W, Yan M, Li K, Wu X, Wu J, Zhang Z, Dai Y.   +8 more
europepmc   +4 more sources

Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1 [PDF]

Scientific Reports
Glioblastoma (GBM) is highly malignant and grows rapidly, and there is currently a lack of effective treatments. Metabolism provides the basis for the occurrence and development of GBM.
Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang   +6 more
doaj   +4 more sources