Molecular Genetics and Metabolism Reports, 2014 Pyruvate dehydrogenase complex (PDC) deficiencies are mostly due to mutations in the X-linked PDHA1 gene. Males with hemizygous PDHA1 mutations are clinically more severely affected, while those with mosaic PDHA1 mutations may manifest milder phenotypes.
Jirair K Bedoyan +2 more
exaly +6 more sources
Astragaloside IV increases PDHA1 in mesenchymal stem cell exosomes to treat myocardial infarction [PDF]
Scientific ReportsAcute myocardial infarction (AMI) is a threat to health, with high morbidity and mortality, posing a challenge to the public health system. This study aimed to explore the efficacy and potential targets of Astragaloside IV (AS-IV) combined with ...
Du Feng, Feng Du, Zhenqiu Yu
exaly +5 more sources
Frontiers in Pharmacology, 2022 Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Langmei Deng, Anqi Jiang, Xiaoji Peng
exaly +5 more sources
Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate [PDF]
Frontiers in Neuroscience, 2021 Background and Purpose: Neurodegenerative diseases are associated with metabolic disturbances. Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) is an essential component in the process of glucose metabolism, and its deficiency exists in various ...
Tingting Bi, Bi Tingting
exaly +5 more sources
The potential impact of GLS and PDHA1 on tumor immunity and immunotherapy response in LUSC. [PDF]
Front GenetBackgroundLung squamous cell carcinoma (LUSC), a therapeutically challenging non-small cell lung cancer (NSCLC) subtype with a poor prognosis, exhibits heterogeneous responses to immunotherapy.
Ling T, Wu J, Xiaohao L.
europepmc +4 more sources
SIRT3 regulates PDHA1 acetylation in HUVECs to modulate inflammation and pyroptosis under clinorotation. [PDF]
iScienceSummary: Microgravity-induced endothelial inflammation contributes to cardiovascular dysfunction in astronauts, but the metabolic mechanisms involved are not fully defined. Sirtuin-3 (SIRT3), a mitochondrial deacetylase, regulates cellular metabolism and
Jiang M +9 more
europepmc +4 more sources
PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2. [PDF]
Cell Death DiscovCells that detach from the extracellular matrix (ECM) undergo various forms of cell death, including ferroptosis. Previous studies have demonstrated that prostate cancer (PCa) cells undergo ferroptosis following ECM detachment, and resistance to ...
Cong Y +10 more
europepmc +4 more sources
Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1-PD-L1 axis: a multi-omics and clinical validation study. [PDF]
NPJ Precis OncolSarcomas are aggressive, immunologically cold tumors with limited benefit from immune-checkpoint blockade (ICB). Through integrated multi-omics, functional, and clinical analyses, we identify pyruvate dehydrogenase alpha 1 (PDHA1)—a cuproptosis-linked ...
Qin H +10 more
europepmc +2 more sources
Mitochondrial PDHA1 acetylation orchestrates lactate-dependent epigenetic reprogramming to promote fibrosis via NUAK2. [PDF]
Cell Mol Life SciIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with few effective treatment options. While metabolic reprogramming has been associated with IPF, the precise mechanisms connecting mitochondrial metabolic dysfunction to ...
Wang Y +11 more
europepmc +2 more sources
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer. [PDF]
Cell Death DisAcquired resistance to enzalutamide (Enz) presents a significant challenge in castration-resistant prostate cancer (CRPC), and overcoming this resistance remains an unmet clinical need.
Zhuang R +12 more
europepmc +2 more sources