Results 21 to 30 of about 3,856 (123)

Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer

Frontiers in Immunology, 2022
IntroductionBreast cancer (BC) has been ranking first in incidence and the leading cause of death among female cancers worldwide based on the latest report. Regulated cell death (RCD) plays a significant role in tumor initiation and provides an important
Tingting Huang, Yankuo Liu, Jiwei Li, Bingbing Shi, Zhengda Shan, Zhiyuan Shi, Zhangru Yang   +6 more
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Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth

Cancer & Metabolism, 2021
Background Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle.
Nancy P. Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina Scott, McKenzie Kreamer, Martin Benej, Tereza Golias, Ioanna Papandreou, Nicholas C. Denko   +8 more
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Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis

Journal for ImmunoTherapy of Cancer, 2023
Background anti-Programmed Death-1 (anti-PD-1) immunotherapy has shown promising manifestation in improving the survival rate of patients with advanced melanoma, with its efficacy closely linked to Programmed cell death-Ligand 1 (PD-L1) expression ...
Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Mingjie Yan, Cong Peng   +5 more
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Development and Evaluation of Recombinant B-Cell Multi-Epitopes of PDHA1 and GAPDH as Subunit Vaccines against Streptococcus iniae Infection in Flounder (Paralichthys olivaceus)

Vaccines, 2023
Streptococcus iniae is a severe Gram-positive pathogen that can infect a wide range of freshwater and marine fish species. In continuation of our earlier studies on the development of S.
Xiuzhen Sheng, Honghua Zhang, Min Liu, Xiaoqian Tang, Jing Xing, Heng Chi, Wenbin Zhan   +6 more
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PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation

Cell Death and Disease, 2023
The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its mechanism remain unclear.
Sheng An, Yi Yao, Hongbin Hu, Junjie Wu, Jiaxin Li, Lulan Li, Jie Wu, Maomao Sun, Zhiya Deng, Yaoyuan Zhang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng   +13 more
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Difficulties in recognition of pyruvate dehydrogenase complex deficiency on the basis of clinical and biochemical features. The role of next-generation sequencing

Molecular Genetics and Metabolism Reports, 2016
Pyruvate dehydrogenase complex (PDHc) defect is a well-known cause of mitochondrial disorders (MD) with at least six responsible genes (PDHA1, PDHB, DLAT, DLD, PDHX, PDP1). The aim of this work was to assess the diagnostic value of biochemical methods in
E. Ciara, D. Rokicki, P. Halat, A. Karkucińska-Więckowska, D. Piekutowska-Abramczuk, J. Mayr, J. Trubicka, T. Szymańska-Dębińska, M. Pronicki, M. Pajdowska, M. Dudzińska, M. Giżewska, M. Krajewska-Walasek, J. Książyk, W. Sperl, R. Płoski, E. Pronicka   +16 more
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Machine learning algorithms for a novel cuproptosis-related gene signature of diagnostic and immune infiltration in endometriosis

Scientific Reports, 2023
Endometriosis (EMT) is an aggressive disease of the reproductive system, also called “benign cancer”. However, effective treatments for EMT are still lacking in clinical practice.
Jiajia Wang, Yiming Lu, Guangyu Sun, Zhihao Fang, Zhiyong Xing, Weihua Nong, Yunbao Wei, Shan Wang, Guiling Shi, Mingyou Dong, Junli Wang   +10 more
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Vitamin D-VDR (vitamin D receptor) alleviates glucose metabolism reprogramming in lipopolysaccharide-induced acute kidney injury

Frontiers in Physiology, 2023
Background: Our previous study showed that vitamin D (VD)-vitamin D receptor (VDR) plays a nephroprotective role in lipopolysaccharide (LPS)-induced acute kidney injury (AKI).
Qing Dai, Hao Zhang, Shiqi Tang, Xueqin Wu, Jianwen Wang, Bin Yi, Jishi Liu, Zhi Li, Qin Liao, Aimei Li, Yan Liu, Wei Zhang   +11 more
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Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification

Frontiers in Immunology, 2023
InstructionUlcerative colitis (UC) can cause a variety of immune-mediated intestinal dysfunctions and is a significant model of inflammatory bowel disease (IBD). Colorectal cancer (CRC) mostly occurs in patients with ulcerative colitis.
Cejun Yang, Cejun Yang, Wendi Wang, Sang Li, Zhengkang Qiao, Xiaoqian Ma, Xiaoqian Ma, Min Yang, Min Yang, Juan Zhang, Juan Zhang, Lu Cao, Lu Cao, Shanhu Yao, Shanhu Yao, Zhe Yang, Wei Wang, Wei Wang   +17 more
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SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

Journal of Translational Medicine, 2021
Background The aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC).
Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan, He Hongchao   +6 more
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