Exploration of PDHA1-related prognostic genes in liver fibrosis. [PDF]
Medicine (Baltimore)Liver fibrosis is characterized by an abnormal accumulation of extracellular matrix proteins, leading to impaired liver function. The pyruvate dehydrogenase alpha 1 (PDHA1) gene, encoding the E1 alpha subunit of the pyruvate dehydrogenase complex, has demonstrated reduced expression in pulmonary fibrosis, suggesting a protective role in fibrotic ...
Zhao Y, Li K.
europepmc +3 more sources
PDHA1–acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer [PDF]
Cell Death and DiseaseAcquired resistance to enzalutamide (Enz) presents a significant challenge in castration-resistant prostate cancer (CRPC), and overcoming this resistance remains an unmet clinical need.
Ruilin Zhuang +12 more
doaj +2 more sources
Data in Brief, 2016 This article presents a dataset proving the simultaneous presence of a 5′UTR-truncated PDHA1 mRNA and a full-length PDHA2 mRNA in the somatic cells of a PDC-deficient female patient and all members of her immediate family (parents and brother).
Ana Pinheiro +10 more
doaj +2 more sources
Function of eEF-1γ in the nucleus in response to insulin in hepatocellular carcinoma cells [PDF]
Communications BiologyInsulin promotes HepG2 cell proliferation by inducing phosphorylation of the pyruvate dehydrogenase E1α (PDHA1) subunit at Ser293, a mechanism distinct from normal liver tissue.
Abu Jubayer Hossain +4 more
doaj +2 more sources
Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia [PDF]
Frontiers in ImmunologyBackgroundPediatric acute myeloid leukemia (AML) is characterized by poor prognosis and low survival rates following recurrence. While mitochondria and programmed cell death (PCD) are implicated in various diseases, their role in pediatric AML remains ...
Xiaoyan Hu +6 more
doaj +2 more sources
Retraction: <i>PDHA1</i> gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence. [PDF]
OncotargetLi Y +11 more
europepmc +3 more sources
Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis. [PDF]
DevelopmentPan C +4 more
europepmc +2 more sources
Differential phenotypic expression of a novel PDHA1 mutation in a female monozygotic twin pair [PDF]
Human Genetics, 2019 Abstract Pyruvate dehydrogenase complex (PDC) deficiency caused by mutations in the X-linked PDHA1 gene has a broad clinical presentation, and the pattern of X-chromosome inactivation has been proposed as a major factor contributing to its variable expressivity in heterozygous females.
Alejandro Horga +19 more
openalex +5 more sources
Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia [PDF]
Scientific Reports, 2020 AbstractAutoantibodies have been implicated in schizophrenia aetiology. Here, novel autoantibodies were isolated from patients with schizophrenia. Autoantibody candidates were searched using two-dimensional gel electrophoresis and western blotting with rat brain proteins as antigens and two sera pools (25 schizophrenia patients versus 25 controls) as ...
Yukako Nakagami +9 more
openalex +3 more sources
Global Gene Expression Profiling of Individual Human Oocytes and Embryos Demonstrates Heterogeneity in Early Development [PDF]
, 2013 Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals.
Brison, Daniel R. +4 more
core +13 more sources