Results 21 to 30 of about 4,222 (186)

Development and Evaluation of Recombinant B-Cell Multi-Epitopes of PDHA1 and GAPDH as Subunit Vaccines against Streptococcus iniae Infection in Flounder (Paralichthys olivaceus)

Vaccines, 2023
Streptococcus iniae is a severe Gram-positive pathogen that can infect a wide range of freshwater and marine fish species. In continuation of our earlier studies on the development of S.
Xiuzhen Sheng, Honghua Zhang, Min Liu, Xiaoqian Tang, Jing Xing, Heng Chi, Wenbin Zhan   +6 more
doaj   +2 more sources

Data supporting the co-expression of PDHA1 gene and of its paralogue PDHA2 in somatic cells of a family

Data in Brief, 2016
This article presents a dataset proving the simultaneous presence of a 5′UTR-truncated PDHA1 mRNA and a full-length PDHA2 mRNA in the somatic cells of a PDC-deficient female patient and all members of her immediate family (parents and brother).
Ana Pinheiro, Maria João Silva, Hana Pavlu-Pereira, Cristina Florindo, Madalena Barroso, Bárbara Marques, Hildeberto Correia, Anabela Oliveira, Ana Gaspar, Isabel Tavares de Almeida, Isabel Rivera   +10 more
doaj   +2 more sources

Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1

Scientific Reports
Glioblastoma (GBM) is highly malignant and grows rapidly, and there is currently a lack of effective treatments. Metabolism provides the basis for the occurrence and development of GBM.
Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang   +6 more
doaj   +2 more sources

Difficulties in recognition of pyruvate dehydrogenase complex deficiency on the basis of clinical and biochemical features. The role of next-generation sequencing

Molecular Genetics and Metabolism Reports, 2016
Pyruvate dehydrogenase complex (PDHc) defect is a well-known cause of mitochondrial disorders (MD) with at least six responsible genes (PDHA1, PDHB, DLAT, DLD, PDHX, PDP1). The aim of this work was to assess the diagnostic value of biochemical methods in
E. Ciara, D. Rokicki, P. Halat, A. Karkucińska-Więckowska, D. Piekutowska-Abramczuk, J. Mayr, J. Trubicka, T. Szymańska-Dębińska, M. Pronicki, M. Pajdowska, M. Dudzińska, M. Giżewska, M. Krajewska-Walasek, J. Książyk, W. Sperl, R. Płoski, E. Pronicka   +16 more
doaj   +2 more sources

Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia. [PDF]

Front Immunol
BackgroundPediatric acute myeloid leukemia (AML) is characterized by poor prognosis and low survival rates following recurrence. While mitochondria and programmed cell death (PCD) are implicated in various diseases, their role in pediatric AML remains ...
Hu X, Zhao Q, Deng W, Li Y, Liu B.
europepmc   +2 more sources

Function of eEF-1γ in the nucleus in response to insulin in hepatocellular carcinoma cells. [PDF]

Commun Biol
Insulin promotes HepG2 cell proliferation by inducing phosphorylation of the pyruvate dehydrogenase E1α (PDHA1) subunit at Ser293, a mechanism distinct from normal liver tissue.
Hossain AJ, Hamza A, Islam R, Dogsom O, Park JB.   +4 more
europepmc   +2 more sources

Manifestations of X‐linked pyruvate dehydrogenase complex deficiency in female PDHA1 carriers

European Journal of Neurology
AbstractBackground and purposePyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X‐linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1‐related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii ...
Antri Savvidou, Kalliopi Sofou, Erik A. Eklund, Johan Aronsson, Niklas Darin   +4 more
openaire   +3 more sources

Neonatal pyruvate dehydrogenase deficiency due to a R302H mutation in the PDHA1 gene: MRI findings [PDF]

Pediatric Radiology, 2008
Pyruvate dehydrogenase (PDH) deficiency is one of the most common causes of congenital lactic acidosis. Correlations between the genetic defect and neuroimaging findings are lacking. We present conventional and diffusion-weighted MRI findings in a 7-day-old male neonate with PDH deficiency due to a mosaicism for the R302H mutation in the PDHA1 gene ...
Soares-Fernandes, JP, Teixeira-Gomes, R, Cruz, R, Ribeiro, M, Magalhães, Z, Rocha, JF, Leijser, LM   +6 more
openaire   +6 more sources

Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia [PDF]

Scientific Reports, 2020
AbstractAutoantibodies have been implicated in schizophrenia aetiology. Here, novel autoantibodies were isolated from patients with schizophrenia. Autoantibody candidates were searched using two-dimensional gel electrophoresis and western blotting with rat brain proteins as antigens and two sera pools (25 schizophrenia patients versus 25 controls) as ...
Nakagami, Yukako, Sugihara, Genichi, Nakashima, Noriyuki, Hazama, Masaaki, Son, Shuraku, Ma, Shuhe, Matsumoto, Riki, Murai, Toshiya, Ikeda, Akio, Murakami, Kosaku   +9 more
openaire   +2 more sources

PLK1-mediated PDHA1 phosphorylation drives metabolic reprogramming in lung cancer. [PDF]

Oncogene
Although the involvement of polo-like kinase 1 (PLK1) in metabolic reprogramming from oxidative phosphorylation (OXPHOS) to glycolysis has been previously described, the underlying molecular mechanism remains unclear. Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate into acetyl-CoA, the starting material for the tricarboxylic acid (TCA)
Peng J, Zhang Q, Rao X, Allison DB, Kong Y, Wang R, Liu J, Zhang Y, Katz W, Li Z, Liu X.   +10 more
europepmc   +3 more sources