Results 31 to 40 of about 5,906 (214)

Pak1 dysregulates pyruvate metabolism in PDAC cells by exerting a phosphorylation-mediated regulatory effect on PDHA1. [PDF]

J Biol Chem
Murugan S, B SSS, Gopinath P, Saravanan R, Sundaram S, Shanmugasundaram G, Venkatraman G, Rayala SK.   +7 more
europepmc   +3 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche [PDF]

, 2017
Background: Scientific research in bio-informatics is often data-driven and supported by biolog- ical databases. In a growing number of research projects, researchers like to ask questions that require the combination of information from more than one ...
Boer, M.L. (Monique) den, Pieters, R. (Rob), Polak, R. (Roel), Rooij, B. (Bob) de, Stalpers, F. (Femke)   +4 more
core   +15 more sources

Females with PDHA1 gene mutations: A diagnostic challenge [PDF]

Mitochondrion, 2006
Biochemical analysis was performed in muscle tissue and in fibroblasts of four unrelated females consecutively diagnosed with a 'de novo' point mutation in the PDHA1 gene. Pyruvate dehydrogenase E1 subunit deficiency was confirmed in the muscle sample of all patients, however, in three out of four cases the activity of the pyruvate dehydrogenase ...
Willemsen, M.A.A.P., Rodenburg, R.J.T., Teszas, A., Heuvel, L.P.W.J. van den, Kosztolanyi, G.Y., Morava, E.   +5 more
openaire   +3 more sources

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation

Biomedicines, 2022
Insulin potently promotes cell proliferation and anabolic metabolism along with a reduction in blood glucose levels. Pyruvate dehydrogenase (PDH) plays a pivotal role in glucose metabolism.
Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park   +5 more
doaj   +1 more source

PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer. [PDF]

J Biol Chem
Zhang Q, Peng J, Li Z, Rao X, Allison DB, Qiao Q, Zhang Z, Kong Y, Zhang Y, Wang R, Liu J, Wang X, Li C, Mao F, Shao Q, Gao T, Liu X.   +16 more
europepmc   +3 more sources

Examination of the molecular control of ruminal epithelial function in response to dietary restriction and subsequent compensatory growth in cattle [PDF]

, 2016
Background The objective of this study was to investigate the effect of dietary restriction and subsequent compensatory growth on the relative expression of genes involved in volatile fatty acid transport, metabolism and cell ...
Kelly, Alan K, Kenny, David A., Keogh, Kate, O'Shea, Emma, Waters, Sinead M.   +4 more
core   +3 more sources

Cardiac-Specific Deletion of thePdha1Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress [PDF]

Toxicological Sciences, 2016
Pyruvate dehydrogenase (PDH) plays a key role in aerobic energy metabolism and occupies a central crossroad between glycolysis and the tricarboxylic acid cycle. We generated inducible cardiac-specific PDH E1α knockout (CreER(T2)-PDH(flox/flox)) mice that demonstrated a high mortality rate.
Wanqing Sun, Nanhu Quan, Lin Wang, Hui Yang, Dongyang Chu, Quan Liu, Xuezhong Zhao, Jiyan Leng, Ji Li   +8 more
  +7 more sources

Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis

Journal for ImmunoTherapy of Cancer, 2023
Background anti-Programmed Death-1 (anti-PD-1) immunotherapy has shown promising manifestation in improving the survival rate of patients with advanced melanoma, with its efficacy closely linked to Programmed cell death-Ligand 1 (PD-L1) expression ...
Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Mingjie Yan, Cong Peng   +5 more
doaj   +1 more source