Results 31 to 40 of about 3,856 (123)
Frontiers in Oncology, 2022 BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier +11 more
doaj +1 more source
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2019 Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate.
Tsai-Ying Chen +13 more
doaj +1 more source
Data in Brief, 2016 This article presents a dataset proving the simultaneous presence of a 5′UTR-truncated PDHA1 mRNA and a full-length PDHA2 mRNA in the somatic cells of a PDC-deficient female patient and all members of her immediate family (parents and brother).
Ana Pinheiro +10 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To construct a prognostic model for neuroblastoma (NB) based on cuproptosis-related genes (CRGs) and improve individualized management of neuroblastoma patients.
XIANG Bin +4 more
doaj +1 more source
Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Advanced Science, EarlyView.Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li +9 more
wiley +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Objective To evaluate the diagnostic utility and genetic spectrum of next‐generation sequencing (NGS) in a large, well‐phenotyped cohort of Turkish pediatric patients with epilepsy of unknown etiology. Methods Between January 2021 and December 2024, 250 children (115 female, 135 male) with unexplained epilepsy underwent either whole‐exome ...
Derya Karaer +4 more
wiley +1 more source
RNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis
npj Precision OncologyThis study investigates the role of RNF4-mediated ubiquitination and degradation of PDHA1 in colorectal cancer (CRC) metabolism and metastasis. Integrating (The Cancer Genome Atlas) TCGA and Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases,
Jierong Chen +7 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2021 Background Leigh syndrome, the most common mitochondrial syndrome in pediatrics, has diverse clinical manifestations and is genetically heterogeneous.
Ke Gong +5 more
doaj +1 more source
Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer
Frontiers in Oncology, 2022 BackgroundCuproptosis, a copper-dependent controlled cell death, is a novel form of cell death that differs from known cell death mechanisms; however, its overall regulation in cancer remains elusive.MethodsMultiple open-source bioinformatic platforms ...
Cankun Zhou +3 more
doaj +1 more source