Results 31 to 40 of about 4,222 (186)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation

Biomedicines, 2022
Insulin potently promotes cell proliferation and anabolic metabolism along with a reduction in blood glucose levels. Pyruvate dehydrogenase (PDH) plays a pivotal role in glucose metabolism.
Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park   +5 more
doaj   +1 more source

Exploration of PDHA1-related prognostic genes in liver fibrosis. [PDF]

Medicine (Baltimore)
Liver fibrosis is characterized by an abnormal accumulation of extracellular matrix proteins, leading to impaired liver function. The pyruvate dehydrogenase alpha 1 (PDHA1) gene, encoding the E1 alpha subunit of the pyruvate dehydrogenase complex, has demonstrated reduced expression in pulmonary fibrosis, suggesting a protective role in fibrotic ...
Zhao Y, Li K.
europepmc   +3 more sources

table7_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.xlsx

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

table2_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.xlsx

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

image1_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.tif

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

image3_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.tif

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

table5_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.xlsx

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

GLUTAMINE DEPRIVATION AFFECTS THE EXPRESSION OF GENES WHICH CONTROL PYRUVATE DEHYDROGENASE ACTIVITY: THE IMPACT OF ERN1 KNOCKDOWN [PDF]

Biotechnologia Acta, 2022
The aim of the current investigation was to study the expression of genes encoded pyruvate dehydrogenase subunits (PDHA1, PDHB, PDHX, DLAT, and DLD) in U87 glioma cells in response to glutamine deprivation in U87 glioma cells in relation to knockdown of ...
M. Sliusar, H. Shatokhina, A. Cherednychenko, O. Minchenko   +3 more
doaj   +1 more source

image4_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.tif

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source