Results 51 to 60 of about 4,222 (186)

image2_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.tif

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

table6_Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer.xlsx

, 2022
Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Xiaoji Peng (13210572), Liying Song (2802685), Anqi Jiang (4583380), Langmei Deng (11845673), Hanqing Zeng (694794)   +4 more
core   +1 more source

Image_1_Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate.pdf

, 2021
Background and Purpose: Neurodegenerative diseases are associated with metabolic disturbances. Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) is an essential component in the process of glucose metabolism, and its deficiency exists in various ...
Xiaoxia Sun (684999), Libin Zhan (532915), Tingting Bi (599907), Wanxin Chen (10228151), Wen Zhou (49050)   +4 more
core   +1 more source

Machine learning algorithms for a novel cuproptosis-related gene signature of diagnostic and immune infiltration in endometriosis

Scientific Reports, 2023
Endometriosis (EMT) is an aggressive disease of the reproductive system, also called “benign cancer”. However, effective treatments for EMT are still lacking in clinical practice.
Jiajia Wang, Yiming Lu, Guangyu Sun, Zhihao Fang, Zhiyong Xing, Weihua Nong, Yunbao Wei, Shan Wang, Guiling Shi, Mingyou Dong, Junli Wang   +10 more
doaj   +1 more source

Vitamin D-VDR (vitamin D receptor) alleviates glucose metabolism reprogramming in lipopolysaccharide-induced acute kidney injury

Frontiers in Physiology, 2023
Background: Our previous study showed that vitamin D (VD)-vitamin D receptor (VDR) plays a nephroprotective role in lipopolysaccharide (LPS)-induced acute kidney injury (AKI).
Qing Dai, Hao Zhang, Shiqi Tang, Xueqin Wu, Jianwen Wang, Bin Yi, Jishi Liu, Zhi Li, Qin Liao, Aimei Li, Yan Liu, Wei Zhang   +11 more
doaj   +1 more source

Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification

Frontiers in Immunology, 2023
InstructionUlcerative colitis (UC) can cause a variety of immune-mediated intestinal dysfunctions and is a significant model of inflammatory bowel disease (IBD). Colorectal cancer (CRC) mostly occurs in patients with ulcerative colitis.
Cejun Yang, Cejun Yang, Wendi Wang, Sang Li, Zhengkang Qiao, Xiaoqian Ma, Xiaoqian Ma, Min Yang, Min Yang, Juan Zhang, Juan Zhang, Lu Cao, Lu Cao, Shanhu Yao, Shanhu Yao, Zhe Yang, Wei Wang, Wei Wang   +17 more
doaj   +1 more source

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

Journal of Translational Medicine, 2021
Background The aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC).
Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan, He Hongchao   +6 more
doaj   +1 more source

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier, Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, José I. López, Rafael Pulido, Rafael Pulido   +11 more
doaj   +1 more source

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2019
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate.
Tsai-Ying Chen, Yi-Ta Hsieh, Jian-Min Huang, Chung-Ji Liu, Lu-Te Chuang, Pei-Chun Huang, Tz-Yu Kuo, Hao-Yuan Chia, Chia-Yi Chou, Ching-Wen Chang, Yi-Fen Chen, Hsin-Ming Chen, Jeng-Fan Lo, Wan-Chun Li   +13 more
doaj   +1 more source

Construction and validation of acuproptosis-related prognostic model in neuroblastoma based on TARGET, ArrayExpress and GEO databases

陆军军医大学学报, 2023
Objective To construct a prognostic model for neuroblastoma (NB) based on cuproptosis-related genes (CRGs) and improve individualized management of neuroblastoma patients.
XIANG Bin, CHEN Meiling, CAO Lijian, HE Xueyu, TIAN Xiaomao   +4 more
doaj   +1 more source