Results 51 to 60 of about 5,906 (214)

A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes [PDF]

, 2016
We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers.
Heath, James R., Johnson, Hannah, Kravchenko-Balasha, Nataly, Levine, R. D., White, Forest M.   +4 more
core   +3 more sources

Difficulties in recognition of pyruvate dehydrogenase complex deficiency on the basis of clinical and biochemical features. The role of next-generation sequencing

Molecular Genetics and Metabolism Reports, 2016
Pyruvate dehydrogenase complex (PDHc) defect is a well-known cause of mitochondrial disorders (MD) with at least six responsible genes (PDHA1, PDHB, DLAT, DLD, PDHX, PDP1). The aim of this work was to assess the diagnostic value of biochemical methods in
E. Ciara, D. Rokicki, P. Halat, A. Karkucińska-Więckowska, D. Piekutowska-Abramczuk, J. Mayr, J. Trubicka, T. Szymańska-Dębińska, M. Pronicki, M. Pajdowska, M. Dudzińska, M. Giżewska, M. Krajewska-Walasek, J. Książyk, W. Sperl, R. Płoski, E. Pronicka   +16 more
doaj   +1 more source

Machine learning algorithms for a novel cuproptosis-related gene signature of diagnostic and immune infiltration in endometriosis

Scientific Reports, 2023
Endometriosis (EMT) is an aggressive disease of the reproductive system, also called “benign cancer”. However, effective treatments for EMT are still lacking in clinical practice.
Jiajia Wang, Yiming Lu, Guangyu Sun, Zhihao Fang, Zhiyong Xing, Weihua Nong, Yunbao Wei, Shan Wang, Guiling Shi, Mingyou Dong, Junli Wang   +10 more
doaj   +1 more source

Vitamin D-VDR (vitamin D receptor) alleviates glucose metabolism reprogramming in lipopolysaccharide-induced acute kidney injury

Frontiers in Physiology, 2023
Background: Our previous study showed that vitamin D (VD)-vitamin D receptor (VDR) plays a nephroprotective role in lipopolysaccharide (LPS)-induced acute kidney injury (AKI).
Qing Dai, Hao Zhang, Shiqi Tang, Xueqin Wu, Jianwen Wang, Bin Yi, Jishi Liu, Zhi Li, Qin Liao, Aimei Li, Yan Liu, Wei Zhang   +11 more
doaj   +1 more source

Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification

Frontiers in Immunology, 2023
InstructionUlcerative colitis (UC) can cause a variety of immune-mediated intestinal dysfunctions and is a significant model of inflammatory bowel disease (IBD). Colorectal cancer (CRC) mostly occurs in patients with ulcerative colitis.
Cejun Yang, Cejun Yang, Wendi Wang, Sang Li, Zhengkang Qiao, Xiaoqian Ma, Xiaoqian Ma, Min Yang, Min Yang, Juan Zhang, Juan Zhang, Lu Cao, Lu Cao, Shanhu Yao, Shanhu Yao, Zhe Yang, Wei Wang, Wei Wang   +17 more
doaj   +1 more source

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

Journal of Translational Medicine, 2021
Background The aim of this study was to investigate the biological functions and underlying mechanisms of SIRT5 in clear cell renal cell carcinoma (ccRCC).
Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan, He Hongchao   +6 more
doaj   +1 more source

Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein [PDF]

, 2014
A method for non-invasive visualization of genetically labelled cells in animal disease models with micron-level resolution would greatly facilitate development of cell-based therapies.
A Sacco, A Sakaue-Sawano, A Vagin, AJ Lam, AJ McCoy, Amy J Lam, BJ Tromberg, BW Rice, CC Mello, CH Contag, Christopher H Contag, D Shcherbo, D Shcherbo, Emilio González-González, GE Eldred, GN Murshudov, GS Filonov, GS Harms, Helen M Blau, Ho-Leung Ng, J Condeelis, J Pražnikar, John S Burg, Jun Chu, K Christopher Garcia, KA Schenkman, Kang Shen, KS Morozova, LS Murdaugh, M Monici, Michael W Davidson, Michael Z Lin, Michelle A Baird, MZ Lin, MZ Lin, NC Deliolanis, NC Shaner, Niloufar J Ataie, OM Subach, P Emsley, Paula J Cranfill, PD Adams, Pengpeng Li, PM Gilbert, R Kerr, R Shinde, RB Bass, Russell D Haynes, SP Nighswander-Rempel, Stéphane Y Corbel, T Schroeder, TS Walter, UT Brunk, W Kabsch, X Shu, Y Inoue, Y Kawai   +56 more
core   +2 more sources

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier, Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, José I. López, Rafael Pulido, Rafael Pulido   +11 more
doaj   +1 more source

A multicenter study on Leigh syndrome: Disease course and predictors of survival [PDF]

, 2014
Background: Leigh syndrome is a progressive neurodegenerative disorder, associated with primary or secondary dysfunction of the mitochondrial oxidative phosphorylation.
Angst, I.B. (Isabel) de, Bindoff, L.A. (Laurence Albert), Coo, I.F.M. (René) de, Darin, N. (Niklas), Isohanni, M.K. (Matti), Lönnqvist, T. (Tuula), Mankinen, K. (Katariina), Meirleir, L. (Linda) de, Naess, K. (Karin), Ostergaard, M., Pihko, H. (Helena), Sofou, K. (Kalliopi), Tulinius, M. (Már), Tzoulis, C. (Charalampos), Uusimaa, J. (Johanna)   +14 more
core   +1 more source

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2019
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate.
Tsai-Ying Chen, Yi-Ta Hsieh, Jian-Min Huang, Chung-Ji Liu, Lu-Te Chuang, Pei-Chun Huang, Tz-Yu Kuo, Hao-Yuan Chia, Chia-Yi Chou, Ching-Wen Chang, Yi-Fen Chen, Hsin-Ming Chen, Jeng-Fan Lo, Wan-Chun Li   +13 more
doaj   +1 more source