Results 61 to 70 of about 3,856 (123)

Health Benefits and Molecular Mechanisms of Urolithin A: From a Gut Microbiota‐Derived Metabolite to Translational Applications

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Urolithin A (UA) is a gut microbiota‐derived metabolite produced from dietary ellagitannins and ellagic acid, with endogenous formation varying among urolithin metabotypes (UM‐A, UM‐B, and UM‐0). UA regulates an interconnected network centered on mitophagy and mitochondrial quality control, antioxidant defense, inflammatory signaling, autophagy, and ...
Zijiang Yang, Chenggen Guo, Ziao Deng, Xinxuan Xue   +3 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Conservation Status of Two Italian Local Poultry Breeds: Faraona Camosciata and Oca Padovana

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The present study aimed to assess the conservation status and characterize the phenotypic and genomic diversity of two endangered Italian poultry genetic resources to guide their conservation plans. Blood samples and morphometric data were collected on 50 Faraona Camosciata (FAC, Numida meleagris) and 50 Oca Padovana (OPD, Anser anser) adult ...
Filippo Cendron, Enrico Bortoletto, Francesco Perini, Maristella Baruchello, Umberto Rosani, Emiliano Lasagna, Martino Cassandro, Mauro Penasa   +7 more
wiley   +1 more source

Implementation of First‐Line Rapid Genome Sequencing for Children in Pediatric and Cardiac Intensive Care Units

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1326-1336, June 2026.
ABSTRACT Substantial data supports the use of rapid exome and genome sequencing (rES/rGS) in Neonatal Intensive Care Units (NICU), but fewer studies have examined the impact of rES/rGS in other pediatric critical care units. We evaluated the impact on diagnostic yield and time to diagnosis following a single‐center hospital policy change allowing ...
Alexandra C. Keefe, Abbey A. Scott, Lukas Kruidenier, Jessie Conta, Darci L. Sternen, Sarah V. Clowes Candadai, Shannon M. Stasi, Julia Parish‐Morris, Megan Sikes, Margaret P. Adam, Anita E. Beck, Jennifer C. Hayek, Ian Glass, James T. Bennett, Ghayda Mirzaa, Paul Kruszka, Britt Johnson, Kirsty McWalter, Deborah Copenheaver, Bethany Friedman, Michael Bamshad, Katrina M. Dipple, Tara L. Wenger   +22 more
wiley   +1 more source

Hepatoprotective Potential of Walnut Oil Unsaponifiable Matter on Aging‐Induced Liver Injury via Gut Microbiota–Liver Axis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
USM protects against aging‐induced liver injury by modulating the gut‐liver axis. It enriches beneficial microbiota (e.g., Akkermansia and Lactobacillus) and upregulates tight junction proteins (ZO‐1, Occludin, Claudin) to restore the intestinal barrier.
Junjun Zhou, Dan Hong, Rujin Bai, Xinhui Wang, Shijie Zhu, Qiming Tian, Junxia Xia, Zhou Chen, Siting Li, Yingmin Jia, Aijin Ma   +10 more
wiley   +1 more source

Analysis of cuproptosis-related genes in prognosis and immune infiltration in grade 4 diffuse gliomas

Heliyon
Background: Grade 4 diffuse gliomas are highly malignant tumours with poor prognosis. Cuproptosis is a novel form of cell death. Cuproptosis genes are associated with various tumours and affect the prognosis of patients with these tumours.
Hui Liu, Xin Bao, Zhirui Zeng, Wei Liu, Meifang Li   +4 more
doaj   +1 more source

SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

Cancer Medicine, 2019
Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery and chemotherapy are still not effective in improving outcomes in CCA patients.
Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang   +11 more
doaj   +1 more source

Glucose‐Induced Developmental Dynamics: Understanding Male Prevalence in Early Mouse Embryo Stages

Reproductive Medicine and Biology
Purpose Glucose plays a critical role in early embryonic development, influencing metabolic dynamics and developmental competence in a sex‐specific manner.
Fikri Ardhani, Asako Okamoto, Masayuki Shimada   +2 more
doaj   +1 more source

Oxygen-glucose deprivation preconditioning alleviates oxygen-glucose deprivation/reperfusion injury in PC12 cells by protecting mitochondria

陆军军医大学学报
Objective To investigate the protective effect of oxygen-glucose deprivation preconditioning (OGDPC) on PC12 cells damaged with oxygen-glucose deprivation/reperfusion (OGD/R) and its underlying mechanism.
HUANG Li, HUANG Li, XU Na, YANG Chaoxian
doaj   +1 more source

TFF1-mediated suppression of the TCA cycle promotes bone metastasis in triple-negative breast cancer. [PDF]

Transl Oncol
Chen H, Xu Y, Liu Y, Tang Y, Qiu J, Lei L, Lin P, Chen Y, Wu X.   +8 more
europepmc   +1 more source