Results 71 to 80 of about 4,222 (186)

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

Scientific Reports, 2022
Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased
V. F. E. D. Smolders, C. Rodríguez, I. Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Morén, C. Bonjoch, L. Sebastián, M. Castellà, J. Osorio, V. I. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J. A. Barberà, O. Tura-Ceide   +18 more
doaj   +1 more source

Conservation Status of Two Italian Local Poultry Breeds: Faraona Camosciata and Oca Padovana

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The present study aimed to assess the conservation status and characterize the phenotypic and genomic diversity of two endangered Italian poultry genetic resources to guide their conservation plans. Blood samples and morphometric data were collected on 50 Faraona Camosciata (FAC, Numida meleagris) and 50 Oca Padovana (OPD, Anser anser) adult ...
Filippo Cendron, Enrico Bortoletto, Francesco Perini, Maristella Baruchello, Umberto Rosani, Emiliano Lasagna, Martino Cassandro, Mauro Penasa   +7 more
wiley   +1 more source

Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer

Frontiers in Oncology, 2022
BackgroundCuproptosis, a copper-dependent controlled cell death, is a novel form of cell death that differs from known cell death mechanisms; however, its overall regulation in cancer remains elusive.MethodsMultiple open-source bioinformatic platforms ...
Cankun Zhou, Chaomei Li, Yuhua Zheng, Xiaobin Huang   +3 more
doaj   +1 more source

Implementation of First‐Line Rapid Genome Sequencing for Children in Pediatric and Cardiac Intensive Care Units

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1326-1336, June 2026.
ABSTRACT Substantial data supports the use of rapid exome and genome sequencing (rES/rGS) in Neonatal Intensive Care Units (NICU), but fewer studies have examined the impact of rES/rGS in other pediatric critical care units. We evaluated the impact on diagnostic yield and time to diagnosis following a single‐center hospital policy change allowing ...
Alexandra C. Keefe, Abbey A. Scott, Lukas Kruidenier, Jessie Conta, Darci L. Sternen, Sarah V. Clowes Candadai, Shannon M. Stasi, Julia Parish‐Morris, Megan Sikes, Margaret P. Adam, Anita E. Beck, Jennifer C. Hayek, Ian Glass, James T. Bennett, Ghayda Mirzaa, Paul Kruszka, Britt Johnson, Kirsty McWalter, Deborah Copenheaver, Bethany Friedman, Michael Bamshad, Katrina M. Dipple, Tara L. Wenger   +22 more
wiley   +1 more source

Telitacicept alleviates IgA nephropathy by targeting PDHA1 lactylation to inhibit B cell metabolic reprogramming and lactate-mediated renal injury

European Journal of Medical Research
Background Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis, is driven by galactose-deficient IgA1 (Gd-IgA1) production from autoreactive B cells.
Lu Xu, Jing-Jing Zhang, Wen-Ting Xu
doaj   +1 more source

ERN1 dependent impact of glutamine and glucose deprivations on the pyruvate dehydrogenase genes expression in glioma cells

Endocrine Regulations, 2022
Objective. The aim of the present study was to investigate the expression of pyruvate dehydrogenase genes such as PDHA1, PDHB, DLAT, DLD, and PDHX in U87 glioma cells in response to glutamine and glucose deprivations in control glioma cells and ...
Shatokhina Hanna O., Khita Olena O., Minchenko Dmytro O., Tsymbal Dariia O., Luzina Olha R., Danilovskyi Serhiy V., Sliusar Myroslava Y., Levadna Liudmyla O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Pyruvate Dehydrogenase Contributes to Drug Resistance of Lung Cancer Cells Through Epithelial Mesenchymal Transition

Frontiers in Cell and Developmental Biology, 2022
Recently, there has been a growing interest on the role of mitochondria in metastatic cascade. Several reports have shown the preferential utilization of glycolytic pathway instead of mitochondrial respiration for energy production and the pyruvate ...
Buse Cevatemre, Buse Cevatemre, Engin Ulukaya, Egemen Dere, Sukru Dilege, Ceyda Acilan, Ceyda Acilan   +6 more
doaj   +1 more source

Hepatoprotective Potential of Walnut Oil Unsaponifiable Matter on Aging‐Induced Liver Injury via Gut Microbiota–Liver Axis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
USM protects against aging‐induced liver injury by modulating the gut‐liver axis. It enriches beneficial microbiota (e.g., Akkermansia and Lactobacillus) and upregulates tight junction proteins (ZO‐1, Occludin, Claudin) to restore the intestinal barrier.
Junjun Zhou, Dan Hong, Rujin Bai, Xinhui Wang, Shijie Zhu, Qiming Tian, Junxia Xia, Zhou Chen, Siting Li, Yingmin Jia, Aijin Ma   +10 more
wiley   +1 more source

Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing

Genes and Diseases, 2023
To uncover the role of satellite cells (SCs) in paravertebral muscle development and aging, we constructed a single-nucleus transcriptomic atlas of mouse paravertebral muscle across seven timepoints spanning the embryo (day 16.5) to old (month 24) stages.
Xin Qiu, Hao-Yu Wang, Zhen-Yu Yang, Li-Ming Sun, Shu-Nan Liu, Chui-Qin Fan, Feng Zhu   +6 more
doaj   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source