Results 91 to 100 of about 5,906 (214)

Serum‐Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults

Aging Cell, Volume 25, Issue 4, April 2026.
We show unique signatures of small noncoding RNA cargos and mitochondrial proteins in serum EVs and muscle‐derived EVs associated with age‐related mobility resilience. These findings suggest a role for serum EVs in mediating molecular communication related to functional aging phenotypes and underscore the potential of EV biomarkers.
Nicholas F. Fitz, Ashish Kumar, Yixin Su, Mitu Sharma, Sangeeta Singh, Radosveta Koldamova, Iliya Lefterov, Amrita Sahu, Fabrisia Ambrosio, Caterina Rosano, Gagan Deep   +10 more
wiley   +1 more source

Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing

Genes and Diseases, 2023
To uncover the role of satellite cells (SCs) in paravertebral muscle development and aging, we constructed a single-nucleus transcriptomic atlas of mouse paravertebral muscle across seven timepoints spanning the embryo (day 16.5) to old (month 24) stages.
Xin Qiu, Hao-Yu Wang, Zhen-Yu Yang, Li-Ming Sun, Shu-Nan Liu, Chui-Qin Fan, Feng Zhu   +6 more
doaj   +1 more source

Single muscle fiber proteomics reveals unexpected mitochondrial specialization [PDF]

, 2015
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here, we developed a high-sensitivity workflow to characterize the proteome of single fibers.
A. S., Deshmukh, Cancellara, Pasqua, I., Moretti, M., Mann, M., Zeiler, Murgia, Marta, N., Nagaraj, Reggiani, Carlo, Schiaffino, Stefano   +8 more
core   +1 more source

The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears (Ursus arctos)

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Unlike humans, brown bears (Ursus arctos) uniquely preserve skeletal muscle mass and function during months of hibernation despite prolonged fasting and inactivity. We investigated how mitochondrial energetics respond in skeletal muscle to support this remarkable resilience.
Audrey Bergouignan, John Noone, Charlotte Brun, Laura Cussonneau, Alexandre Geffroy, Cecile Coudy‐Gandilhon, Isabelle Chery, Alina Lynn Evans, Jon Martin Arnemo, Jonas Kindberg, Guillemette Gauquelin‐Koch, Donal O'Gorman, Etienne Lefai, Fabrice Bertile   +13 more
wiley   +1 more source

Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish [PDF]

, 2014
The adult skeletal muscle is a plastic tissue with a remarkable ability to adapt to different levels of activity by altering its excitability, its contractile and metabolic phenotype and its mass.
Palstra, Arjan P., Planas Vilarnau, Josep, Rizo Roca, David, Rovira i Berger, Mireia, Spaink, Herman P., Torrella Guio, Joan Ramon   +5 more
core   +2 more sources

OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4‐PBA

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Roberta Besio, Elisa Maffioli, Erika Palladino, Alessandra Sala, Nadia Garibaldi, Valerio Izzi, Antonella Forlino, Gabriella Tedeschi   +7 more
wiley   +1 more source

Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction

Frontiers in Cardiovascular Medicine, 2018
Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension.
Keshav Gopal, Keshav Gopal, Keshav Gopal, Malak Almutairi, Malak Almutairi, Malak Almutairi, Rami Al Batran, Rami Al Batran, Rami Al Batran, Farah Eaton, Farah Eaton, Farah Eaton, Manoj Gandhi, Manoj Gandhi, Manoj Gandhi, John Reyes Ussher, John Reyes Ussher, John Reyes Ussher   +17 more
doaj   +1 more source

Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]

, 2014
The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia, Giulivi, Cecilia, Napoli, Eleonora   +2 more
core   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Neonatal pyruvate dehydrogenase deficiency due to a R302H mutation in the PDHA1 gene: MRI findings [PDF]

Pediatric Radiology, 2008
Pyruvate dehydrogenase (PDH) deficiency is one of the most common causes of congenital lactic acidosis. Correlations between the genetic defect and neuroimaging findings are lacking. We present conventional and diffusion-weighted MRI findings in a 7-day-old male neonate with PDH deficiency due to a mosaicism for the R302H mutation in the PDHA1 gene ...
Soares-Fernandes, JP, Teixeira-Gomes, R, Cruz, R, Ribeiro, M, Magalhães, Z, Rocha, JF, Leijser, LM   +6 more
openaire   +4 more sources