Results 101 to 110 of about 5,906 (214)

Dual role of Sirtuin 3 in carcinogenesis [PDF]

, 2019
Različiti oblici raka jedan od najčešćih uzroka smrtnosti širom svijeta, a s obzirom da mnogi terapeutici vremenom gube djelotvornost, potrebno je razviti nove strategije liječenja.
Ciganek, Ivan
core  

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism [PDF]

, 2019
A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation.
Albrechtsen, N., Araki, E., Batista, T., Cai, W., Cederquist, C., Damasio, M., Enerback, S., Gupta, M., Homan, E., Kahn, C., Mann, M., Ramirez, A., Sakaguchi, M., Singh, S., Steger, M., Wang, C.   +15 more
core   +2 more sources

Expert‐Designed Fact Sheets and AI‐Based Analysis of Patient Symptoms to Combat Diagnostic Delays in Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The importance of early diagnosis of inherited metabolic diseases (IMDs) is well known, as it allows early intervention to prevent or reduce complications and improve prognosis, since many of these disorders are treatable. However, diagnosis can still be delayed, and many patients remain undiagnosed. Reducing diagnosis delays is a primary goal
Aline Cano, Xiaoyi Chen, Azza Khemiri, Anais Brassier, Arnoux Jean‐Baptiste, Roseline Froissart, Juliette Bouchereau, Célia Hoebeke, Karin Mazodier, Bénédicte Héron, Philippe Labrune, Catherine Caillaud, David Cheillan, Yann Nadjar, Samia Pichard, Apolline Imbard, Magali Pettazzoni, Claire Douillard, Belmatoug Nadia, Anna‐Line Calatayud, Mounira Zerguini, Nicolas Garcelon, Jean‐François Benoist, Cécile Acquaviva, Pascale De Lonlay, the other members of the expert group consortium, Marie‐Thérèse Abi‐Warde, Cécile Acquaviva, Jean‐Baptiste Arnoux, Stéphanie Badiou, Magalie Barth, Nadia Belmatoug, Jean‐François Benoist, Juliette Bouchereau, Anais Brassier, Arnaud Bruneel, Catherine Caillaud, Aline Cano, Brigitte Chabrol, David Cheillan, Emmanuelle Corbe‐Guillard, Christelle Corne, Lena Damaj, Myriam Dao, Pascale De Lonlay, Anne‐Frédérique Dessein, Dries Dobbelaere, Claire Douillard, Thierry Dupré, François Feillet, Roseline Froissart, Margaux Gaschignard, Magali Gorce, Laurent Gouya, Anne‐Sophie Guemann, Bénédicte Héron, Célia Hoebeke, Apolline Imbard, Elsa Kaphan, François Labarthe, Philippe Labrune, Pascal Laforet, Thierry Levade, Elise Lebigot, Edouard Le Guillou, Olivier Lidove, Julien Maquet, Wladimir Mauhin, Clothilde Marbach, Karin Mazodier, Karine Mention, Fanny Mochel, Caroline Moreau, Yann Nadjar, Esther Noel, Mickael Obadia, Cécile Pagan, Magali Pettazzoni, Samia Pichard, Clement Pontoizeau, Aurélia Poujois, Isabelle Redonnet‐Vernhet, Frédérique Sabourdy, Manuel Schiff, Christine Serratrice, Aude Servais, Caroline Sevin, Anne Spraul, Bénédicte Sudrié, Marine Tardieu, Sandrine Vuillaumier, Camille Wicker, Arnaud Wiedemann‐Fode, Vincent Barlogis, Nathalie Boddaert, Kanetee Busiah, Annabelle Chaussenot, Dominique Debray, Céline Falaise, Muriel Girard, Dalila Habes, Annie Harroche, Florence Lacaille, Mehdi Oualha, Caroline Ovaert, Rachel Reynaud, Caroline Rousset‐Rouvière, Cécile Rouzier, Karim Wahbi   +108 more
wiley   +1 more source

Building pathway clusters from Random Forests classification using class votes [PDF]

, 2008
Background Recent years have seen the development of various pathway-based methods for the analysis of microarray gene expression data. These approaches have the potential to bring biological insights into microarray studies.
Herbert Pang, Hongyu Zhao, M Kanehisa, KD Dahlquist, A Subramanian, H Pang, SW Kong, I Dinu, VK Mootha, GC Tseng, Y Wang, LD Miller, M West, AE Teschendorff, E Huang, GA Colditz, DA Berry, A Naderi, R Lupu, A Liaw, P Shannon, JJ Goeman, KG Becker, C Strobl, S Peri, Y Zhu, R Greenberg, M Nacht, LK Diaz, S Vgenopoulou, E Seregni, T Felton, EA Williamson, HJ Kang, R Bos, G Gruber, FJ Fleming   +36 more
core   +2 more sources

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Manifestations of X‐linked pyruvate dehydrogenase complex deficiency in female PDHA1 carriers

European Journal of Neurology
AbstractBackground and purposePyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X‐linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1‐related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii ...
Antri Savvidou, Kalliopi Sofou, Erik A. Eklund, Johan Aronsson, Niklas Darin   +4 more
openaire   +2 more sources

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer [PDF]

, 2017
Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to enhance the invasive and metastatic ability of ...
Akimoto Miho, Hayashi Jun-Ichi, Koshikawa Nobuko, Nagase Hiroki, Takenaga Keizo, 林 純一   +5 more
core   +2 more sources

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Erythropoietin signaling regulates heme biosynthesis [PDF]

, 2017
Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Acin-Perez, Altarejos, Amieux, Amigo, Balwani, Bauer, Beale, Boer, Boer, Burden, Burns, Canver, Carbognin, Chen, Chida, Chung, Chung, Chung, Dailey, Danial, Dar, Decker, Dey, DiPilato, Eggers, Fujiwara, Fujiwara, Ganis, Gidari, Gieger, Goessling, Gough, Grimsrud, Hagiwara, Handschin, Harada, Hebert, Hildick-Smith, Huang, Huang, Humphries, Hunter, Ishikawa, Jing, Kammerer, Kardon, Kirschner, Kuhrt, Langendonk, Lefkimmiatis, Li, Li, Lodish, Maeda, Manni, Mayr, Meier, Najahi-Missaoui, Nilsson, North, Pagliarini, Paradkar, Park, Phillips, Rapaport, Sakaino, Sarma, Schneider, Schooley, Severance, Shah, Shaw, Shirihai, Smith, Socolovsky, Socolovsky, Stratakis, Su, Taylor, Testa, Tingley, Vogel, Wang, Webb, Wegrzyn, Wenger, Whatley, Wingert, Wong, Wu, Yang, Yang, Yien, Zakhary, Zhang, Zhu, Zon   +96 more
core   +2 more sources

Genomic Counter-Stress Changes Induced by the Relaxation Response [PDF]

, 2013
Background: Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced ...
Benson, Herbert, Bhasin, Manoj, Dusek, Jeffery A., Joseph, Marie G., Libermann, Towia Aron, Otu, Hasan H, Wohlhueter, Ann L., Zerbini, Luiz F.   +7 more
core   +1 more source