Results 121 to 130 of about 5,906 (214)

PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

Oncotarget, 2016
Alternative pathways of metabolism endowed cancer cells with metabolic stress. Inhibiting the related compensatory pathways might achieve synergistic anticancer results. This study demonstrated that pyruvate dehydrogenase E1α gene knockout (PDHA1 KO) resulted in alterations in tumor cell metabolism by rendering the cells with increased expression of ...
Li, Yaqing, Li, Xiaoran, Li, Xiaoli, Zhong, Yali, Ji, Yasai, Yu, Dandan, Zhang, Mingzhi, Wen, Jian-Guo, Zhang, Hongquan, Goscinski, Mariusz Adam, Nesland, Jahn M., Suo, Zhenhe   +11 more
openaire   +3 more sources

Neurophysiological profile of peripheral neuropathy associated with childhood mitochondrial disease [PDF]

, 2016
INTRODUCTION: Peripheral nerve involvement is common in mitochondrial disease but often unrecognised due to the prominent central nervous system features.
Bhattacharya, K, Christodoulou, J, Clark, D, Ellaway, C, Farrar, M, Menezes, MP, Ouvrier, R, Pitt, M, Rahman, S, Ryan, MM, Sampaio, H, Thorburn, DR, Ware, TL, Wedatilake, Y   +13 more
core   +1 more source

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]

, 2016
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB, Bell, CC, Ellis, E, Goldring, CE, Hendriks, DFG, Ingelman-Sundberg, M, Johansson, I, Lauschke, VM, Mkrtchian, S, Moro, SML, Nordling, A, Park, BK, Rezayee, F, Sison-Young, R, Vorrink, SU   +14 more
core   +1 more source

Diagnostic Targeted Resequencing in 349 Patients with Drug-Resistant Pediatric Epilepsies Identifies Causative Mutations in 30 Different Genes [PDF]

, 2017
Targeted resequencing gene panels are used in the diagnostic setting to identify gene defects in epilepsy. We performed targeted resequencing using a 30-genes panel and a 95-genes panel in 349 patients with drug-resistant epilepsies beginning in the ...
Barba, C, Bianchini, C, Bigoni, S, Cellini, E, Chiti, L, Clinical Study Group, De Vita, D, Galuppi, A, Guerrini, R, MANGANO, Salvatore, Mari, F, Marini, C, Mei, D, Montomoli, M, Parrini, E, Pisano, T, Pucatti, D, Rosati, A, Rutigliano, D, Virdò, S   +19 more
core   +1 more source

Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow [PDF]

, 2014
How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to ...
Adams, Bae, Böttcher, Cheng, Cheng Cheng Zhang, Ding, Fatih Kocabas, Guo-Qiang Chen, Göthert, Harman, Hesham Sadek, Holt, Huynh, Ito, Jude, Junke Zheng, Kocabas, Krishnaraju, Lu, Mercedes Costell, Miharada, Min, Miquel, Miyamoto, Nohl, Peled, Pervaiz, Qianming Wang, Ralph J. DeBerardinis, Ralph T. Böttcher, Rust, Scott, Simsek, Sperandio, Takubo, Tothova, Turrens, Turrens, Vara Prasad, Verheyen, Witke, Witke, Xiaoye Liu, Xunlei Kang, Yun, Zheng, Zheng, Zheng, Zhigang Lu, Zoidakis   +49 more
core   +2 more sources

Clinical and Genetic Examination of Limb Developmental Defects [PDF]

, 2010
8
Tészás Alexandra
core  

Glucose‐Induced Developmental Dynamics: Understanding Male Prevalence in Early Mouse Embryo Stages

Reproductive Medicine and Biology
Purpose Glucose plays a critical role in early embryonic development, influencing metabolic dynamics and developmental competence in a sex‐specific manner.
Fikri Ardhani, Asako Okamoto, Masayuki Shimada   +2 more
doaj   +1 more source

Oxygen-glucose deprivation preconditioning alleviates oxygen-glucose deprivation/reperfusion injury in PC12 cells by protecting mitochondria

陆军军医大学学报
Objective To investigate the protective effect of oxygen-glucose deprivation preconditioning (OGDPC) on PC12 cells damaged with oxygen-glucose deprivation/reperfusion (OGD/R) and its underlying mechanism.
HUANG Li, HUANG Li, XU Na, YANG Chaoxian
doaj   +1 more source

Mild Phenotype in a Male with Pyruvate Dehydrogenase Complex Deficiency Associated with Novel Hemizygous In-Frame Duplication of the E1α Subunit Gene (PDHA1) [PDF]

, 2013
Jon G. Steller, J. Jay Gargus, Liliane Gibbs, Anton N. Hasso, Virginia Kimonis   +4 more
openalex   +1 more source

Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1 [PDF]

, 2023
Kangli Peng, Shirong Wang, Ruochuan Liu, Li Zhou, Geon Jeong, In Ho Jeong, Xianpeng Liu, Hiroaki Kiyokawa, Bingzhong Xue, Bo Zhao, Hang Shi, Jun Yin   +11 more
openalex   +1 more source