Results 111 to 120 of about 5,906 (214)

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

ESEfinder: a web resource to identify exonic splicing enhancers [PDF]

, 2003
Point mutations frequently cause genetic diseases by disrupting the correct pattern of pre-mRNA splicing. The effect of a point mutation within a coding sequence is traditionally attributed to the deduced change in the corresponding amino acid.
Cartegni, L., Wang, J. H., Zhu, Z. W., Zhang, M. Q., Krainer, A. R.   +4 more
core   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

The effects of death and post-mortem cold ischemia on human tissue transcriptomes [PDF]

, 2018
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels.
Aguet, François, Amador, Raziel, Amadoz, Alicia, Ardlie, Kristin G., Breschi, Alessandra, 1988-, Carbonell-Caballero, Jose, Curado, Joao, Dopazo, Joaquín, Ferreira, Pedro G., Godinho, Caio P. Sá, Guigó Serra, Roderic, Hidalgo, Marta R., Muñoz-Aguirre, Manuel, Nurtdinov, Ramil, Oliveira, Carla, Oliveira, Patrícia, Pervouchine, Dmitri D., Reverter, Ferran, Sammeth, Michael, Sodaei, Reza, 1988-, Sousa, Abel, Çubut, Cankut   +21 more
core   +5 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

MAP7D2 is a brain expressing X-linked maternal imprinted gene in humans [PDF]

, 2011
Increasing evidence suggests imprinted genes influence mouse and human behaviors and cognitive functions. Unlike autosomal imprinted genes, X-linked imprinted genes are expressed in a sex-dependent manner because of male hemizygosity.
Akihiro Yachie, Yo Niida
core   +1 more source

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins [PDF]

, 2008
We report an advanced chemoenzymatic strategy for the direct fluorescence detection, proteomic analysis, and cellular imaging of O-GlcNAc-modified proteins.
Agnew, Brian J., Buck, Suzanne B., Clark, Peter M., Dweck, Jessica F., Hart, Courtenay R., Hsieh-Wilson, Linda C., Mason, Daniel E., Peters, Eric C.   +7 more
core   +1 more source

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer

Oncotarget, 2015
The glucose metabolism reprogramming is a hallmark of cancer. The oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development of breast cancer. In this study, we supposed that HBXIP might be involved in the glucose metabolism reprogramming in breast cancer.
Fabao, Liu, Weiying, Zhang, Xiaona, You, Yunxia, Liu, Yinghui, Li, Zhen, Wang, Yue, Wang, Xiaodong, Zhang, Lihong, Ye   +8 more
openaire   +3 more sources

Analysis of cuproptosis-related genes in prognosis and immune infiltration in grade 4 diffuse gliomas

Heliyon
Background: Grade 4 diffuse gliomas are highly malignant tumours with poor prognosis. Cuproptosis is a novel form of cell death. Cuproptosis genes are associated with various tumours and affect the prognosis of patients with these tumours.
Hui Liu, Xin Bao, Zhirui Zeng, Wei Liu, Meifang Li   +4 more
doaj   +1 more source

Phen-Gen: combining phenotype and genotype to analyze rare disorders

, 2014
We introduce Phen-Gen, a method which combines patient disease symptoms and sequencing data with prior domain knowledge to identify the causative gene(s) for rare ...
Agrawal, Saloni, Javed, Asif, Ng, Pauline C.   +2 more
core   +1 more source