Results 111 to 120 of about 4,222 (186)

Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma

, 2019
Most cancers rely disproportionately on glycolysis for energy even in the presence of an adequate oxygen supply, a condition known as “aerobic glycolysis,” or the “Warburg effect.” Pyruvate dehydrogenase E1α subunit (PDHA1) is one of the main factors ...
Jihong Sun, Qiuyue Hu, Lu Sun, Hongli Gu, Yubing Zhou, Jingjing Li, Zhixian Guo, Quancheng’ Kan, Zujiang Yu, Chenghui Juan, Yan Yu   +10 more
core   +1 more source

Cardiac-Specific Knock-out of PDHA1 Leading to Mitochondrial Dysfunction and Progressive Heart Damage

Background Genetic mutations that create pyruvate dehydrogenase complex (PDHc) deficiencies are a primary cause of congenital lactic acidosis (CLA). CLA is a rare genetic disorder in which the mitochondrion is unable to effectively metabolize excess ...
Nielson, Grace K, Schulte, Collin T, Wilcox, Reesa M, Wang, Han-Jun   +3 more
core  

Photoreceptor deletion of pyruvate dehydrogenase E1 subunit α1 induces retinal degeneration and reprograms retinal metabolism. [PDF]

Mol Metab
Ma H, York LR, Li S, Gagnon G, Zou J, Yu H, Yang J, Le Y, Eminhizer M, Mascari I, Du J, Ding XQ.   +11 more
europepmc   +1 more source

A Nationwide Study of Pyruvate Dehydrogenase Complex Deficiency in Sweden: Epidemiology, Genotype-Phenotype Correlations, and Survival. [PDF]

Neurology
Savvidou A, Sofou K, Thunström S, Ygberg S, Eklund EA, Naess K, Kollberg G, Darin N.   +7 more
europepmc   +1 more source

d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation. [PDF]

Sci Adv
Wu Z, Hu Q, Shen Y, Fu J, Liu B, Zhang M, Hung I, Liu C, Ren W.   +8 more
europepmc   +1 more source

Acetate Metabolism in Thyroid Cancer Progression. [PDF]

Int J Mol Sci
Baldini E, Cardarelli S, Lori E, Fallahi P, Virili C, Centanni M, D'Andrea V, Antonelli A, Sorrenti S, Ulisse S.   +9 more
europepmc   +1 more source

A modified Atkin's diet for an infant with pyruvate dehydrogenase complex deficiency confirmed by PDHA1 gene mutation

, 2014
Pyruvate dehydrogenase complex deficiency (PDCD) is one of the most common neurodegenerative disorders associated with abnormal mitochondrial metabolism.
이진성, 김정아, 고윤희, 유리타미영, 김흥동, 강훈철   +5 more
core  

Prospective Breast Cancer Biomarkers Identified Using miR-526b-Driven Metabolic Alterations. [PDF]

Cancer Inform
Nault B, Majumder M.
europepmc   +1 more source

Clinical Phenotype Comparison in Polish Patient Cohorts with and Without Molecular Diagnosis of Dystonia. [PDF]

J Clin Med
Milanowski L, Jurek M, Salińska A, Podwysocka A, Figura M, Szlufik S, Geremek M, Nowak J, Szczałuba K, Hoffman-Zacharska D, Koziorowski D.   +10 more
europepmc   +1 more source

Characterization of Fiber-Type Composition and Phosphoproteins of Fast- and Slow-Growing Broilers. [PDF]

Animals (Basel)
Li Y, Huo W, Weng K, Liu J, Gu Y, Cai Y, Zhang Y, Zhang Y, Hu X, Chen G, Xu Q.   +10 more
europepmc   +1 more source