Results 81 to 90 of about 4,222 (186)

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

, 2023
The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior of tumors has been certificated. Nevertheless, the detailed function and molecular mechanism of ceRNA associated with cuproptosis in hepatocellular carcinoma (HCC)
Yong Pan, Shibo Li, Shibo Li (550898), Xiaodan Hu (820376), Yong Pan (24522), Yiru Zhang, Yiru Zhang (5903930), Xiaodan Hu   +7 more
core   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Machine learning-based solution reveals cuproptosis features in inflammatory bowel disease

Frontiers in Immunology, 2023
BackgroundCuproptosis, a new cell death mode, is majorly modulated by mitochondrial metabolism and protein lipoylation. Nonetheless, cuproptosis-related genes (CRGs) have not yet been thoroughly studied for their clinical significance and relationship ...
Le Liu, Liping Liang, Liping Liang, Chenghai Yang, Ye Chen, Ye Chen, Ye Chen   +6 more
doaj   +1 more source

Supplemental Material - Insulin reduces pyroptosis-induced inflammation by PDHA1 dephosphorylation-mediated NLRP3 activation during myocardial ischemia-reperfusion injury

, 2022
Supplemetary Material for Insulin reduces pyroptosis-induced inflammation by PDHA1 dephosphorylation-mediated NLRP3 activation during myocardial ischemia-reperfusion injury by Si-si Pan, Feng Wang, Yong-peng Hui, Kai-yuan Chen, Liu Zhou, Wei-long Gao ...
Kai-yuan Chen (12505078), Hong-kun Wu (12505084), Gui-you Liang (12505096), Si-si Pan (12505072), Xuan-yi Hu (12505093), Liu Zhou (8596884), Feng Wang (44414), Si-yuang Yang (12505090), Yong-peng Hui (12505075), Wei-long Gao (12505081), Deng-sheng Zhang (12505087)   +10 more
core   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Cuproptosis, a recently identified and copper‐dependent form of regulated cell death, has emerged as a potential therapeutic target for a variety of diseases. This review synthesizes current evidence from PubMed to elucidate the mechanisms of cuproptosis and its implications in common orthopaedic disorders, including arthritis, bone tumours ...
Chaoshuai Wang, Pengfei An
wiley   +1 more source

Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction

Frontiers in Cardiovascular Medicine, 2018
Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension.
Keshav Gopal, Keshav Gopal, Keshav Gopal, Malak Almutairi, Malak Almutairi, Malak Almutairi, Rami Al Batran, Rami Al Batran, Rami Al Batran, Farah Eaton, Farah Eaton, Farah Eaton, Manoj Gandhi, Manoj Gandhi, Manoj Gandhi, John Reyes Ussher, John Reyes Ussher, John Reyes Ussher   +17 more
doaj   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Genetic analysis of the Pdha1 locus in control and PDC-deficient female progeny.

, 2013
(A) Depiction of wild-type (Pdha1wt), floxed (Pdha1flox8), and null (Pdha1Δex8) Pdha1 alleles and the primers (arrows above the allele representations) used for genotypic analysis. (B) Genotypic analysis of the Pdha1 locus in brain (B), liver (L), heart (
Mulchand S. Patel (327354), Kathryn A. Hausknecht (426954), Michal K. Stachowiak (426955), Lioudmila Pliss (426953), Jerry B. Richards (426957), Cynthia A. Dlugos (426956)   +5 more
core   +1 more source

Serum‐Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults

Aging Cell, Volume 25, Issue 4, April 2026.
We show unique signatures of small noncoding RNA cargos and mitochondrial proteins in serum EVs and muscle‐derived EVs associated with age‐related mobility resilience. These findings suggest a role for serum EVs in mediating molecular communication related to functional aging phenotypes and underscore the potential of EV biomarkers.
Nicholas F. Fitz, Ashish Kumar, Yixin Su, Mitu Sharma, Sangeeta Singh, Radosveta Koldamova, Iliya Lefterov, Amrita Sahu, Fabrisia Ambrosio, Caterina Rosano, Gagan Deep   +10 more
wiley   +1 more source