Results 81 to 90 of about 5,906 (214)

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Telitacicept alleviates IgA nephropathy by targeting PDHA1 lactylation to inhibit B cell metabolic reprogramming and lactate-mediated renal injury

European Journal of Medical Research
Background Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis, is driven by galactose-deficient IgA1 (Gd-IgA1) production from autoreactive B cells.
Lu Xu, Jing-Jing Zhang, Wen-Ting Xu
doaj   +1 more source

ERN1 dependent impact of glutamine and glucose deprivations on the pyruvate dehydrogenase genes expression in glioma cells

Endocrine Regulations, 2022
Objective. The aim of the present study was to investigate the expression of pyruvate dehydrogenase genes such as PDHA1, PDHB, DLAT, DLD, and PDHX in U87 glioma cells in response to glutamine and glucose deprivations in control glioma cells and ...
Shatokhina Hanna O., Khita Olena O., Minchenko Dmytro O., Tsymbal Dariia O., Luzina Olha R., Danilovskyi Serhiy V., Sliusar Myroslava Y., Levadna Liudmyla O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Pyruvate Dehydrogenase Contributes to Drug Resistance of Lung Cancer Cells Through Epithelial Mesenchymal Transition

Frontiers in Cell and Developmental Biology, 2022
Recently, there has been a growing interest on the role of mitochondria in metastatic cascade. Several reports have shown the preferential utilization of glycolytic pathway instead of mitochondrial respiration for energy production and the pyruvate ...
Buse Cevatemre, Buse Cevatemre, Engin Ulukaya, Egemen Dere, Sukru Dilege, Ceyda Acilan, Ceyda Acilan   +6 more
doaj   +1 more source

Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment [PDF]

, 2015
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect†, commonly exists in a variety of tumors ...
Budihardjo, Calvin Justus, Chen, Dang, Edward Sanderlin, Floridi, Forsythe, Gleadle, Goh, Griffiths, Gu, Helmlinger, Li Yang, Martelli, McComb, Metallo, Minn, Ohtsubo, Patlolla, Presta, Sanderlin, Semenza, Shen, Song, Stein, Sui, Tannock, Thews, Thews, Vander Heiden, Vaupel, Warburg, Welsh, Wick, Wiesener, Xie, Yang, Yang, Ziello   +38 more
core   +3 more sources

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Machine learning-based solution reveals cuproptosis features in inflammatory bowel disease

Frontiers in Immunology, 2023
BackgroundCuproptosis, a new cell death mode, is majorly modulated by mitochondrial metabolism and protein lipoylation. Nonetheless, cuproptosis-related genes (CRGs) have not yet been thoroughly studied for their clinical significance and relationship ...
Le Liu, Liping Liang, Liping Liang, Chenghai Yang, Ye Chen, Ye Chen, Ye Chen   +6 more
doaj   +1 more source

Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]

, 2015
Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
core   +1 more source

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. [PDF]

, 2017
X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst stage.
Anastassiadis, Konstantinos, Ancelin, Katia, Barillot, Emmanuel, Borensztein, Maud, Chen, Chong-Jian, Diabangouaya, Patricia, Galupa, Rafael, Guilbaud, Guillaume, Heard, Edith, Okamoto, Ikuhiro, Picard, Christel, Saitou, Mitinori, Servant, Nicolas, Surani, Azim, Syx, Laurène   +14 more
core   +3 more sources