GLUTAMINE DEPRIVATION AFFECTS THE EXPRESSION OF GENES WHICH CONTROL PYRUVATE DEHYDROGENASE ACTIVITY: THE IMPACT OF ERN1 KNOCKDOWN [PDF]
Biotechnologia Acta, 2022 The aim of the current investigation was to study the expression of genes encoded pyruvate dehydrogenase subunits (PDHA1, PDHB, PDHX, DLAT, and DLD) in U87 glioma cells in response to glutamine deprivation in U87 glioma cells in relation to knockdown of ...
M. Sliusar +3 more
doaj +1 more source
MITOCHONDRIAL NEUROPATHY IN PEDIATRIC PATIENTS CARRYING MTDNA, POLG1, SURF1, AND PDHA1 MUTATIONS
Journal of Medical Biomedical And Applied Sciences, 2018 Josef finester
openalex +3 more sources
Identification of cuproptosis-related genes for predicting the development of prostate cancer
Open Medicine, 2023 Copper can be toxic at very high intracellular concentrations and can inhibit prostate cancer (PCa) progression. Recently, a study reported the mechanism of cuproptosis and the potentially associated genes.
Wang Xin’an +4 more
doaj +1 more source
Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer
Frontiers in Immunology, 2022 IntroductionBreast cancer (BC) has been ranking first in incidence and the leading cause of death among female cancers worldwide based on the latest report. Regulated cell death (RCD) plays a significant role in tumor initiation and provides an important
Tingting Huang +6 more
doaj +1 more source
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer [PDF]
, 2018 Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied.
Bauer, Matthew R. +19 more
core +1 more source
Cancer & Metabolism, 2021 Background Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle.
Nancy P. Echeverri Ruiz +8 more
doaj +1 more source
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells. [PDF]
, 2018 Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of ...
Costa, Ana SH +7 more
core +2 more sources
Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training [PDF]
, 2013 We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exercise ...
A. J. Murton +8 more
core +2 more sources
Vaccines, 2023 Streptococcus iniae is a severe Gram-positive pathogen that can infect a wide range of freshwater and marine fish species. In continuation of our earlier studies on the development of S.
Xiuzhen Sheng +6 more
doaj +1 more source
Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. [PDF]
, 2020 BackgroundHyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate of metabolism through glycolytic pathways in human prostate cancer.
Aggarwal, Rahul +13 more
core