Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils [PDF]
Scientific Reports, 2023 At present, the impact of cuproptosis-related genes in the study of osteosarcoma is largely unknown. Genome-wide data of osteosarcoma and controls were downloaded from 3 different databases, and specific diagnostic models associated with cuproptosis in ...
Jie Jiang +18 more
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Frontiers in Pharmacology, 2022 Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells.
Langmei Deng +4 more
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PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation [PDF]
Cell Death and Disease, 2023 The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its mechanism remain unclear.
Sheng An +13 more
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RNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis
Npj Precision OncologyThis study investigates the role of RNF4-mediated ubiquitination and degradation of PDHA1 in colorectal cancer (CRC) metabolism and metastasis. Integrating (The Cancer Genome Atlas) TCGA and Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases,
Jierong Chen +7 more
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Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia [PDF]
Discover OncologyBackground Acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis. Recent studies highlight cuproptosis, a copper-dependent cell death mechanism, as a potential therapeutic target in cancers.
Tianping Chen +8 more
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SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1 [PDF]
Journal of Cell Communication and Signaling, 2022 AbstractAdipocytes are the most abundant cell type in the adipose tissue, and their dysfunction is a significant driver of obesity-related pathologies, such as cancer. The mechanisms that (1) drive the maintenance and secretory activity of adipocytes and (2) mediate the cancer cellular response to the adipocyte-derived factors are not fully understood.
Michael N Vansaun +1 more
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PLK1-mediated PDHA1 phosphorylation drives metabolic reprogramming in lung cancer. [PDF]
OncogenePeng J +10 more
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Molecular Genetics and Metabolism Reports, 2014 Pyruvate dehydrogenase complex (PDC) deficiencies are mostly due to mutations in the X-linked PDHA1 gene. Males with hemizygous PDHA1 mutations are clinically more severely affected, while those with mosaic PDHA1 mutations may manifest milder phenotypes.
Kristin K. Deeb +9 more
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SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis [PDF]
Cancer Medicine, 2019 Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery and chemotherapy are still not effective in improving outcomes in CCA patients.
Lei Xu +11 more
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miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer
Oncology Reports, 2018 Pyruvate dehydrogenase A1 (PDHA1) is a component of the pyruvate dehydrogenase enzyme complex, which links glycolysis and the tricarboxylic acid cycle, and is important for cancer metabolism shift. PDHA1 downregulation has been revealed in several types of cancer to enhance glycolysis.
Miao Yu, Tonghui
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