Results 201 to 210 of about 181,145 (327)

Synergistic therapeutic impact of dichloroacetate nanoparticles and doxorubicin in modulating pyruvate dehydrogenase kinase in breast carcinoma model. [PDF]

Sci Rep
Salem MM, Khattab AT, Beltagy DM, El-Keiy MM.   +3 more
europepmc   +1 more source

Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid. [PDF]

Sci Rep, 2022
Raut J, Islam MM, Sherpa RD, Sarkar B, Mandal SM, Hui SP, Mandal S, Sahoo P.   +7 more
europepmc   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Elevated Level of Cerebrospinal Fluid Pyruvate Dehydrogenase Kinase 4 Is a Predictive Biomarker of Clinical Outcome after Subarachnoid Hemorrhage. [PDF]

Brain Sci, 2022
Gao X, Zhang H, Peng Z, Zhuang Z, Li W.
europepmc   +1 more source

Pyruvate dehydrogenase kinase 1 (PDK1) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer. [PDF]

Cancer Sci
Ye Y, Ou Z, Li C, Liao Q, Zeng Q, Ju X, Zhang D, Wei Y, Zhang X, Zhang T, Wu K.   +10 more
europepmc   +1 more source

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. [PDF]

Int J Mol Sci, 2022
Tiersma JF, Evers B, Bakker BM, Jalving M, de Jong S.   +4 more
europepmc   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Small Gold Nanoparticles Alleviate Huntington's Disease via Modulating p38α Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1. [PDF]

ACS Nano
Lee LKC, Leong LI, Shyngys M, Bai Q, Lui YL, Cui C, Liu S, Xiao Y, Chan CKW, Cheung WH, Kwan KM, Chan HYE, Choi CHJ.   +12 more
europepmc   +1 more source