Results 211 to 220 of about 131,923 (336)

Synergistic therapeutic impact of dichloroacetate nanoparticles and doxorubicin in modulating pyruvate dehydrogenase kinase in breast carcinoma model. [PDF]

Sci Rep
Salem MM, Khattab AT, Beltagy DM, El-Keiy MM.   +3 more
europepmc   +1 more source

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. [PDF]

Int J Mol Sci, 2022
Tiersma JF, Evers B, Bakker BM, Jalving M, de Jong S.   +4 more
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid. [PDF]

Sci Rep, 2022
Raut J, Islam MM, Sherpa RD, Sarkar B, Mandal SM, Hui SP, Mandal S, Sahoo P.   +7 more
europepmc   +1 more source

Role of pyruvate dehydrogenase kinase 1 (PDHK1) in tumorigenesis and metastasis of ovarian cancer

, 2015
Yuxin Jiang
openalex   +1 more source

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases [PDF]

, 2001
Mulchand S. Patel, Lioubov G. Korotchkina   +1 more
openalex   +1 more source

Pyruvate dehydrogenase kinase 1 (PDK1) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer. [PDF]

Cancer Sci
Ye Y, Ou Z, Li C, Liao Q, Zeng Q, Ju X, Zhang D, Wei Y, Zhang X, Zhang T, Wu K.   +10 more
europepmc   +1 more source

Elevated Level of Cerebrospinal Fluid Pyruvate Dehydrogenase Kinase 4 Is a Predictive Biomarker of Clinical Outcome after Subarachnoid Hemorrhage. [PDF]

Brain Sci, 2022
Gao X, Zhang H, Peng Z, Zhuang Z, Li W.
europepmc   +1 more source