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R-Lipoic Acid Inhibits Mammalian Pyruvate Dehydrogenase Kinase
Free Radical Research, 2004The four pyruvate dehydrogenase kinase (PDK) and two pyruvate dehydrogenase phosphatase (PDP) isoenzymes that are present in mammalian tissues regulate activity of the pyruvate dehydrogenase complex (PDC) by phosphorylation/dephosphorylation of its pyruvate dehydrogenase (E1) component.
Lioubov G, Korotchkina +2 more
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Inhibition of Pyruvate Dehydrogenase Kinase as a Therapeutic Strategy against Cancer.
Current Topics in Medicinal Chemistry, 2018Cancer cells alter their metabolism to support the uninterrupted supply of biosynthetic molecules required for continuous proliferation. Glucose metabolism is frequently reprogrammed in several tumors in addition to fatty acid, amino acid and glutamine ...
S. Sradhanjali, M. Reddy
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Journal of Cellular Physiology, 2018
Patients with ovarian cancer frequently develop acquired drug resistance after the long‐term chemotherapy, leading to disease progression. Enhanced epithelial–mesenchymal transition (EMT) has been implicated in chemoresistance of ovarian cancer cells ...
Meng Zhang +5 more
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Patients with ovarian cancer frequently develop acquired drug resistance after the long‐term chemotherapy, leading to disease progression. Enhanced epithelial–mesenchymal transition (EMT) has been implicated in chemoresistance of ovarian cancer cells ...
Meng Zhang +5 more
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Reproductive Sciences, 2018
Endometriosis is a common gynecological disease, which is defined as the growth of endometrial tissues outside the uterine cavity. It often causes dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in reproductive-age women.
Hsiu-Chi Lee +3 more
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Endometriosis is a common gynecological disease, which is defined as the growth of endometrial tissues outside the uterine cavity. It often causes dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in reproductive-age women.
Hsiu-Chi Lee +3 more
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Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase
Archives of Biochemistry and Biophysics, 2005It has been proposed that "Glu238" within the N-box of pyruvate dehydrogenase kinase (PDK) is a base catalyst. The pH dependence of k(cat) of Arabidopsis thaliana PDK indicates that ionizable groups with pK values of 6.2 and 8.4 are necessary for catalysis, and the temperature dependence of these values suggests that the acidic pK is due to a carboxyl-
Alejandro, Tovar-Méndez +3 more
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Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle
Molecular and Cellular Biochemistry, 1999Chronic sepsis promotes a stable increase in pyruvate dehydrogenase kinase (PDHK) activity in skeletal muscle. PDHK is found tightly bound to the pyruvate dehydrogenase (PDH) complex and as free kinase. We investigated the ability of sepsis to modify the activity of the PDHK intrinsic to the PDH and free PDHK.
T C, Vary, S, Hazen
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Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy.
Biochimica et biophysica acta. Reviews on cancer, 2021Saleha Anwar +4 more
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Journal of Proteome Research, 2018
Pyruvate dehydrogenase kinases (PDKs) dominate the critical switch between mitochondria-based respiration and cytoplasm-based glycolysis by controlling pyruvate dehydrogenase (PDH) activity.
Wen Zhang, Xiaohui Hu, W. Zhou, K. Tam
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Pyruvate dehydrogenase kinases (PDKs) dominate the critical switch between mitochondria-based respiration and cytoplasm-based glycolysis by controlling pyruvate dehydrogenase (PDH) activity.
Wen Zhang, Xiaohui Hu, W. Zhou, K. Tam
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Pyruvate dehydrogenase kinase 2
AfCS-Nature Molecule Pages, 2006Mulchand Patel +2 more
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Increased pyruvate dehydrogenase kinase activity in response to sepsis
American Journal of Physiology-Endocrinology and Metabolism, 1991The effect of sterile inflammation and sepsis on the proportion of active pyruvate dehydrogenase complex (PDH) in mitochondria isolated from skeletal muscle has been investigated. The proportion of active PDH in mitochondria isolated from septic animals was significantly reduced compared with control under all incubation conditions examined, even in ...
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