Results 251 to 260 of about 149,531 (302)
Evidence for two dinstinct pyruvate kinase genes inEscherichia coliK-12
FEBS Letters, 1983 A strain of Escherichia coli K-12 defective in pyruvate kinase F has been produced. The existence of this mutant, in conjunction with earlier results, strongly suggests that the two pyruvate kinases in this bacterium are distinct forms and not ...
Ronald A Cooper, R A Cooper
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Human Mutation, 1996
Pyruvate kinase (PK) deficiency due to mutations of the PKLR gene is a common cause of hereditary nonspherocytic hemolytic anemia. Thus far, 55 different mutations have been described in patients with PK-deficient hemolytic anemia. Polymorphisms within the PKLR gene and in the tightly linked glucocerebrosidase (GBA) gene suggest that PK deficiency may ...
E, Beutler, L, Baronciani
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Pyruvate kinase (PK) deficiency due to mutations of the PKLR gene is a common cause of hereditary nonspherocytic hemolytic anemia. Thus far, 55 different mutations have been described in patients with PK-deficient hemolytic anemia. Polymorphisms within the PKLR gene and in the tightly linked glucocerebrosidase (GBA) gene suggest that PK deficiency may ...
E, Beutler, L, Baronciani
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“Fluorokinase” and pyruvic kinase
Archives of Biochemistry and Biophysics, 1958Abstract 1. 1. The enzyme catalyzing the CO2-dependent phosphorylation of fluoride by adenosine triphosphate to yield monofluorophosphate, an activity referred to as “fluorokinase,” has been isolated in crystalline form from rabbit muscle extracts. The crystalline enzyme has been found to possess considerable pyruvic kinase activity. 2. 2.
A, TIETZ, S, OCHOA
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Clinical Biochemistry, 1990
Pyruvate kinase (PK) deficiency was initially described by Valentine et al. in 1961. Since then, more than 300 cases have been described, including 65 in Japan. PK deficiency is the most common hereditary nonspherocytic hemolytic anemia among several red cell enzyme defects of the Embden-Meyerhof glycolytic pathway.
S, Miwa, H, Fujii
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Pyruvate kinase (PK) deficiency was initially described by Valentine et al. in 1961. Since then, more than 300 cases have been described, including 65 in Japan. PK deficiency is the most common hereditary nonspherocytic hemolytic anemia among several red cell enzyme defects of the Embden-Meyerhof glycolytic pathway.
S, Miwa, H, Fujii
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The stereochemistry of pyruvate kinase
Biochemical and Biophysical Research Communications, 1970Abstract α-Ketobutyrate enol phosphate consisting of approximately 80% cis and 20% trans isomers was prepared by the Perkow reaction. It was converted by pyruvate kinase in 2H2O, to α-ketobutyrate which on oxidative decarboxylation with hydrogen peroxide gave largely (2 R )-2- 2 H-propionate containing one atom of deuterium ...
W E, Bondinell, D B, Sprinson
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Pyruvate kinase electrophoresis in normal and pyruvate kinase deficient hemolysates
Clinica Chimica Acta, 1974Abstract Two bands of pyruvate kinase activity were demonstrated in normal hemolysates with high voltage electrophoresis at pH 5.3 using cellulose acetate strips. Heterozygotes with red cell pyruvate kinase deficiency also exhibited two bands. Six of ten homozygous patients showed two bands, the remaining four only one band.
B, Wonneberger, W, Schröter
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Pyruvate kinase deficiency in children
Pediatric Blood & Cancer, 2021AbstractBackgroundPyruvate kinase deficiency (PKD) is a rare, autosomal recessive red blood cell enzyme disorder, which leads to lifelong hemolytic anemia and associated complications from the disease and its management.MethodsAn international, multicenter registry enrolled 124 individuals younger than 18 years old with molecularly confirmed PKD from ...
Satheesh Chonat +17 more
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Advances in Enzyme Regulation, 1969
Abstract The mechanism and sequence of events of the induction of liver pyruvate kinase by sucrose and fructose administration were examined. Actinomycin and cycloheximide prevented the sucrose and fructose induced rise in pyruvate kinase activity.
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Abstract The mechanism and sequence of events of the induction of liver pyruvate kinase by sucrose and fructose administration were examined. Actinomycin and cycloheximide prevented the sucrose and fructose induced rise in pyruvate kinase activity.
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Defective erythrocyte pyruvate kinase
Clinica Chimica Acta, 1976A defective pyruvate kinase (EC 2.7.1.40) is described. The abnormal PK is characterized by a shift in the R in equilibrium T equilibrium to the T-state. The Ko.5 for the substrate phosphoenol pyruvate is about 6 times higher than for the normal enzyme, while the KM value for the positive effector Fru-1, 6-P2 is increased.
G E, Staal +3 more
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Pyruvate kinase of Bacillus subtilis
Biochimica et Biophysica Acta (BBA) - Enzymology, 1972Abstract Conditions are reported which stabilize pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) activity in extracts of Bacillus subtilis. These conditions include high protein concentrations and the presence of KCl and phosphoenolpyruvate.
M, Diesterhaft, E, Freese
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