Results 251 to 260 of about 1,722,299 (336)

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment. [PDF]

Biomolecules
Zhang X, Zhang D, Guo J, Shi C, Gong Z.
europepmc   +1 more source

Mitapivat therapy in a patient with nonsense homozygous mutation of the Pyruvate Kinase L/R gene: a case report. [PDF]

Blood Transfus
Ceglie S, Valentini CG, Pellegrino C, Massini G, Teofili L.   +4 more
europepmc   +1 more source

Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome. [PDF]

Signal Transduct Target Ther
Yu C, Liu T, Wang Y, Guo X, Chen Y, Zhao Y, Liu X, Huang W, Zhao S, Mo J, Hu H, Lv P, Wang X, Yang Z, Pan J, Ding G, Sheng J, Liu X, Yang H, Huang HF.   +19 more
europepmc   +1 more source

Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion. [PDF]

Sci Adv
Subleski JJ, Palmieri EM, Walls JF, Hsu S, Bettencourt IA, Gower TR, Durum SK, McVicar DW.   +7 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Pyruvate kinase deficiency links metabolic perturbations to neurodegeneration and axonal protection. [PDF]

Mol Metab
Waller TJ, Collins CA, Dus M.
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Mitapivat for Acquired Pyruvate Kinase Deficiency. [PDF]

Pediatr Blood Cancer
Al-Samkari H.
europepmc   +1 more source

The Role of High Cxcl11 Expression in Ovarian Dysfunction Through NF‐κB and AKT Pathways in a Thin Endometrium Mouse Model

iNew Medicine, EarlyView.
Thin endometrium upregulates Cxcl11, which polarizes ovarian macrophages via NF‐κB/AKT, impairing ovarian function. A new uter‐ovarian signaling axis is identified. ABSTRACT Objective Thin endometrium (TE) is a recognized cause of female infertility, primarily associated with impaired uterine receptivity.
Yulu Yang, Fei Tang, Zihan Meng, Yunxi Bao, Jujun Han, Xiaohua Jiang, Jianye Wang, Ying Wang, Zhaolian Wei   +8 more
wiley   +1 more source

[Clinical analysis of six patients with pyruvate kinase deficiency caused by <i>PKLR</i> variants]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Wang W, Zhao YX, Wang LZ, Jiang F, Yang J, Sun LR, Xu HJ.   +6 more
europepmc   +1 more source