ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
The Functional State of <i>Thermoplasma acidophilum</i> Pyruvate Kinase Relies on an Extra Carboxyl-Terminal Sequence. [PDF]
Int J Mol SciRamírez-Silva L +7 more
europepmc +1 more source
Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis
iNew Medicine, EarlyView.This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang +3 more
wiley +1 more source
Diagnostic value of pyruvate kinase isoenzyme type M2 for colorectal cancer: Evidence from meta-analysis. [PDF]
Medicine (Baltimore)Zhao H, Sun X, Wang Y, Tong J.
europepmc +1 more source
Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli +5 more
wiley +1 more source
Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression. [PDF]
Mol BiomedZhao K +10 more
europepmc +1 more source
Macronutrient and micronutrient profiles of meat types: insights into human health and diet
Journal of the Science of Food and Agriculture, EarlyView.Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş +4 more
wiley +1 more source
Pyruvate Kinase Deficiency: Markedly Decreased Reticulocyte PK Activity and Limited Specificity of the PK/HK Ratio. [PDF]
Int J Mol SciKoleva L +9 more
europepmc +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Energy bars are widely consumed functional foods among athletes and physically active consumers who require convenient sources of sustained energy. Their carbohydrate composition, particularly the type and ratio of digestible sugars such as glucose, fructose and sucrose, strongly influences glycaemic index (GI), postprandial blood glucose ...
Raju Sasikumar +8 more
wiley +1 more source
Overall Survival of Patients With Pyruvate Kinase Deficiency in the UK: A Real-World Study. [PDF]
EJHaemFoy P +11 more
europepmc +1 more source