Results 301 to 310 of about 216,078 (374)

CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging

Aging Cell, EarlyView.
This study investigates the mechanisms of oocyte aging in mice, identifying Calb1 and Rpl23 as key genes involved in calcium ion homeostasis and mitochondrial function. Knockdown of these genes led to mitochondrial dysfunction, meiotic defects, and spindle assembly abnormalities, while their overexpression partially rescued age‐related oocyte defects ...
Yingxue Han, Zihuan Du, Hao Wu, Rong Zhao, Jikang Liu, Shuai Gao, Shenming Zeng   +6 more
wiley   +1 more source

Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV

Aging Cell, EarlyView.
We developed a prediction model of biological age based on 77 plasma proteins that were associated with chronological age in two independent cohorts of PLHIV and one cohort of people without HIV. PLHIV exhibited an increased age advancement that was positively associated with previous co‐infections and non‐AIDS‐related comorbidities, a higher ...
Adriana Navas, Vasiliki Matzaraki, Louise E. van Eekeren, Marc J. T. Blaauw, Albert L. Groenendijk, Wilhelm A. J. W. Vos, Maartje Jacobs‐Cleophas, Jéssica C. dos Santos, André J. A. M. van der Ven, Leo A. B. Joosten, Mihai G. Netea   +10 more
wiley   +1 more source

Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins. [PDF]

Int J Mol Sci
Iqbal S, Islam MZ, Ashraf S, Kim W, Al-Sharabi AA, Ozcan M, Hanashalshahaby E, Zhang C, Uhlén M, Boren J, Turkez H, Mardinoglu A.   +11 more
europepmc   +1 more source

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, EarlyView.
Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu, Changhan Chen, Wuping Liu, Zhixiang Zhao, Yuhua Fan, Zhenjiang Li, Weilun Huang, Tingting Xie, Cheng Luo, Zhouzhou Yao, Qi Guo, Zhiyu Yang, Juan Liu, Yujin Zhang, Rodney E. Kellems, Jian Xia, Ji Li, Yang Xia   +17 more
wiley   +1 more source

Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration. [PDF]

Aging Dis
Rajala A, Rajala RVS.
europepmc   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo. [PDF]

Cardiovasc Res
Cai Z, Satyanarayana G, Song P, Zhao F, You S, Liu Z, Mu J, Ding Y, He B, Zou MH.   +9 more
europepmc   +1 more source

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

Aging Cell, EarlyView.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel, J. Candia, C. Ubaida‐Mohien, T. Tanaka, A. Z. Moore, M. Zhu, G. Fantoni, S. Church, J. D'Agostino, J. Fan, N. Shehadeh, S. De, E. Lehrmann, M. Kaileh, E. Simonsick, R. Sen, J. M. Egan, L. Ferrucci   +17 more
wiley   +1 more source

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source