Results 41 to 50 of about 1,067 (128)

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.

PLoS ONE, 2012
Several neurodegenerative diseases are triggered by proteins containing a polyglutamine (polyQ) stretch expanded beyond a critical threshold. Among these, ataxin-3 (AT3) is the causative agent of spinocerebellar ataxia type-3.
Gaetano Invernizzi, Francesco A Aprile, Antonino Natalello, Andrea Ghisleni, Amanda Penco, Annalisa Relini, Silvia M Doglia, Paolo Tortora, Maria E Regonesi   +8 more
doaj   +1 more source

Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor. [PDF]

PLoS ONE, 2013
The binding of ATP to trimeric P2X receptors (P2XR) causes an enlargement of the receptor extracellular vestibule, leading to opening of the cation-selective transmembrane pore, but specific roles of vestibule amino acid residues in receptor activation ...
Milos B Rokic, Stanko S Stojilkovic, Vojtech Vavra, Pavlo Kuzyk, Vendula Tvrdonova, Hana Zemkova   +5 more
doaj   +1 more source

Health‐Related Quality of Life in Patients With a Head and Neck Sarcoma: A Mixed‐Methods Study

Head &Neck, Volume 47, Issue 11, Page 3086-3097, November 2025.
ABSTRACT Background Patients with head and neck sarcomas (HNS) face unique health‐related quality of life (HRQoL) challenges due to its disease rarity. This study examined and identified the prevalence of generic‐ and location‐specific HRQoL issues.
E. Koffi, C. S. Padilla, C. Drabbe, W. H. Schreuder, C. Zemouri, D. den Hollander, D. J. Grünhagen, S. Sodergren, S. Singer, R. L. Jones, I. M. E. Desar, L. Fauske, M. Pinto, I. Nixon, S. Salah, Ø. S. Bruland, V. L. M. N. Soomers, M. A. J. van de Sande, J. J. de Haan, C. Verhoef, L. C. Steggink, W. J. van Houdt, T. I. Bootsma, M. T. Tesselaar, W. T. A. van der Graaf, O. Husson   +25 more
wiley   +1 more source

Business Intelligence and Strategic Entrepreneurship for Sustainable Development Goals (SDGS) Through: (Green Technology Innovation and Green Knowledge Management)

ECONOMICS
The study aimed to investigate the effect of business intelligence on strategic entrepreneurship and the mediating role of green technology innovation and the moderate role of green knowledge management for sustainable development goals (SDGs) in the ...
Al-Abbadi Lina Hamdan, Alshawabkeh Rawan, Alkhazali Zeyad, Al-Aqrabawi Rowaida, Rumman Amani Abu   +4 more
doaj   +1 more source

Does Green Financing affect the Sustainable Economic Growth of Emerging Economies? Evidence from Panel ARDL Model

ECONOMICS
This study examines the nexus between green finance determinants and sustainable economic growth in Brazil, India, China, and South Africa using a panel Autoregressive Distributed Lag (ARDL) approach.
Pachiyappan Sathish, Balakrishnan Reshma, Joseph Augustine, Patil Anand, Arjun B. S, Gowri Shankar R   +5 more
doaj   +1 more source

Lipid Nanoparticles as an Effective Strategy for Protecting Bioactive Compounds in Passion Fruit Seed Oil

European Journal of Lipid Science and Technology, Volume 127, Issue 9, September 2025.
This schematic illustrates the encapsulation of Passiflora edulis seed oil (PFSO) into lipid nanoparticles (LNP‐PFSO), transforming waste into value. The nanoparticles, optimized for size (126 nm, PDI: 0.19), were characterized (SEM, FTIR, XRD) and tested for antimicrobial and antioxidant activities, with applications in food fortification or active ...
Letícia A. D. Morais, Mateus C. Viana, Natalha V. Pinto, Ana P. Rodrigues, Kelly C. Kato, Vívian M. Benassi, Franciele M. P. Molina, Guilherme Carneiro   +7 more
wiley   +1 more source

A Neutrophil Storage Pool in the Fetal Liver is the Principal Source of the Postnatal Neutrophil Surge

The FASEB Journal, Volume 39, Issue 15, 15 August 2025.
Neutrophils surge in mammalian neonates within 24 h after birth, but their origin is unknown. Here, we show that fetal liver neutrophils accumulate in late gestation via G‐CSF and are released postpartum. In rat and mouse neonates, liver neutrophil numbers drop sharply within 12 h of birth.
Ryo Ishiwata, Yuji Morimoto
wiley   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

STING Agonist Drug Delivery by Bacterial Extracellular Vesicles Induces Synergistic Immuno‐Oncology Responses and Efficient Inhibition of Tumour Growth

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
ABSTRACT Bacterial extracellular vesicles are spherical, nanosized structures with lipid bilayer membranes and can suppress tumour growth in cancer models. However, the efficacy of some of these models is limited. One potential way to enhance their effects is by loading the bacterial vesicles with immunostimulatory molecules.
Jan Lötvall, Negar Ordouzadeh, Rossella Crescitelli, Meghshree Deshmukh, Tao Jin, Kyong‐Su Park   +5 more
wiley   +1 more source

Development of a New Curcumin‐Loaded Dental Varnish for Antimicrobial Photodynamic Therapy Application

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 6, June 2025.
ABSTRACT The main objective of this study was to develop a natural curcumin‐loaded varnish that responds to blue light in an antimicrobial photodynamic therapy‐based approach with photoelimination of targeted cells. Fluoride‐free curcumin‐loaded varnish (CUR‐V) consisting of gum rosin (80 wt%) and ethanol (20 wt%) was loaded with 0, 0.25, and 10.0 wt ...
Patricia Comeau, Maria Luisa Leite, Adriana Manso   +2 more
wiley   +1 more source