Results 121 to 130 of about 346,548 (234)

Development and Validation of POCOKIDS‐Q—A Questionnaire to Assess Post COVID‐19 Symptoms in Children

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim To identify the symptom burden in children and adolescents with post COVID‐19, a validated and reliable instrument is needed, particularly to assess symptoms and their impact on the child. The aim of this study was to describe the development, validation, and reliability of the Post COVID‐19 in Kids Questionnaire (POCOKIDS‐Q), which was ...
C. Angelhoff   +5 more
wiley   +1 more source

Time course of clinical signs and mortality in dogs with severe perioperative acute kidney injury: A scoping review

open access: yesAustralian Veterinary Journal, EarlyView.
Perioperative acute kidney injury (AKI) is a potential cause of anaesthetic mortality in dogs. The time delay between anaesthetic recovery, onset of clinical signs and any subsequent mortality may result in under‐recognition of this complication. This review aimed to explore the literature reporting dogs with severe AKI after general anaesthesia and ...
C.T. Quinn
wiley   +1 more source

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

open access: yesBJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui   +2 more
wiley   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou   +4 more
wiley   +1 more source

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