Results 51 to 60 of about 48,174 (231)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Against lifetime QALY prioritarianism

, 2017
Lifetime quality-adjusted life-year (QALY) prioritarianism has recently been defended as a reasonable specification of the prioritarian view that benefits to the worse off should be given priority in health-related priority setting.
Anders Herlitz, Herlitz, Anders,
core   +1 more source

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

Advanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo, Yunwen Wu, Yuhui Guo, Shenghong Ju   +3 more
wiley   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Pharmacoeconomic evaluation of contemporary treatment, prevention, and screening strategies for melanoma: a review of evidence and implications for the Russian healthcare system

Фармакоэкономика
Background. The introduction of immune checkpoint inhibitors (ICIs) and targeted therapies (TTs) has fundamentally changed the clinical management of melanoma, significantly improving survival outcomes both in unresectable disease and in the adjuvant ...
V. M. Polezhaeva, D. S. Beloglazova, E. S. Trunina, A. A. Grinina, A. M. Burmagina, D. N. Gamzova, Yu. M. Kirdyashkina, А. N. Novikov, A. A. Khudiyarov, L. Aydasheva, D. F. Vorobyev, D. R. Khayrutdinova   +11 more
doaj   +1 more source

Loss‐Engineered Terahertz Pixelated Metasensors for Enhanced Molecular Vibrational Fingerprint Sensing

Advanced Science, EarlyView.
This work presents a THz pixelated metasensor that employs loss optimization and spectral overlap for enhanced molecular vibrational fingerprint sensing. The flexible loss rate tuning through the out‐of‐plane dimension allows the device to operate in the optimal fingerprint enhancement condition.
Chenglin Yang, Yuqing Cui, Donghai Han, Yushan Hou, Zhonglei Shen, Andreas Tittl, Liuyang Zhang, Ruqiang Yan, Xuefeng Chen   +8 more
wiley   +1 more source

Качество жизни, обусловленное состоянием здоровья лиц пожилого и старческого возраста (обзор литературы)

Качественная клиническая практика, 2018
Результаты исследования качества жизни (КЖ) у пожилых и стариков представляют существенный интерес для современной науки, имеют большое прикладное значение. Эти данные позволяют оценить субъективное восприятие пациентами ситуации, могут быть использованы

doaj  

Controversies around QALYs [PDF]

Vnitřní lékařství, 2017
The paper summarizes the criticisms of the QALY concept utilization in health-economic evaluations that has been growing stronger in the last years. Despite of its limitations, the QALY concept has been routinely used in many countries incl. the Czech Republic.
Vladimír, Rogalewicz, Miroslav, Barták
openaire   +2 more sources

List of WTP/QALY values from the literature [28–46].

, 2022
List of WTP/QALY values from the literature [28–46].
Masayuki Hashiguchi (707999), Satoko Hori (11133495), Haru Iino (12418572)   +2 more
core   +1 more source

Integrating Automated Electrochemistry and High‐Throughput Characterization with Machine Learning to Explore Si─Ge─Sn Thin‐Film Lithium Battery Anodes

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
A closed‐loop, data‐driven approach facilitates the exploration of high‐performance Si─Ge─Sn alloys as promising fast‐charging battery anodes. Autonomous electrochemical experimentation using a scanning droplet cell is combined with real‐time optimization to efficiently navigate composition space.
Alexey Sanin, Jackson K. Flowers, Tobias H. Piotrowiak, Frederic Felsen, Leon Merker, Alfred Ludwig, Dominic Bresser, Helge Sören Stein   +7 more
wiley   +1 more source