Results 141 to 150 of about 14,659 (232)

Discovery of MK-5661, a Once-Daily Oral Na<sub>V</sub>1.8 Inhibitor for the Treatment of Pain. [PDF]

open access: yesACS Med Chem Lett
Bungard CJ   +19 more
europepmc   +1 more source

Comb‐Driven Coherent Optical Transmitter for Scalable DWDM Interconnects

open access: yesLaser &Photonics Reviews, EarlyView.
A comb‐driven coherent optical transmitter on a Si/SiN platform enables scalable DWDM interconnects by integrating ultra‐compact microring‐assisted modulators and interleavers. High‐baud coherent signaling achieves 400 Gb/s per wavelength and >$>$1 Tb/s multi‐channel transmission, with projected >$>$10 Tb/s per fiber, offering a path toward energy ...
Alireza Geravand   +11 more
wiley   +1 more source

Designing for Dispersibility: How Crystallinity and Solubilizing Groups Affect Quantum Dot Dispersion in Diphenylhexatriene Matrices. [PDF]

open access: yesNano Lett
Kilbride RC   +14 more
europepmc   +1 more source

Thiolate Salt Mediated Dynamic Silyl Ether Exchanges for Polymer Network Design and Deconstruction

open access: yesMacromolecular Rapid Communications, EarlyView.
This work introduces thiolate salts as mediators for dynamic silyl ether exchange. This platform enables the synthesis of reprocessable covalent adaptable polymer networks (CANs) and allows for sterically controlled, and tunable deconstruction of silyl ether‐containing thermosets.
Pierce T. Bombard   +9 more
wiley   +1 more source

Beyond-1000 nm low-energy sunlight-driven photocatalysis enabled by quantum dot-based photon upconversion. [PDF]

open access: yesNatl Sci Rev
Jiang LH   +11 more
europepmc   +1 more source

Oral GLP‐1RA TERN‐601 for Adults With Obesity/Overweight: Placebo‐Controlled, Multiple‐Ascending‐Dose, Phase 1 and 2 Studies

open access: yesObesity, EarlyView.
ABSTRACT Objective The safety, tolerability, pharmacokinetics, and efficacy of TERN‐601, a once‐daily, oral small‐molecule glucagon‐like peptide‐1 (GLP‐1) receptor agonist, were studied in Phase 1 and 2 clinical studies. Methods The Phase 1 (28‐day) and Phase 2 (12‐week), randomized, double‐blind, placebo‐controlled, multiple‐ascending‐dose studies ...
W. Timothy Garvey   +11 more
wiley   +1 more source

Synthesis and application of alginate@CuFe2O4 polymeric spheres in 17‐β‐estradiol adsorption processes in Amazonian rivers

open access: yesPolymer International, EarlyView.
Magnetic alginate beads, functionalized with copper ferrite, effectively remove 17‐β‐estradiol from Amazonian water, exhibiting optimized 238.65 μg g−1 capacity, fast 40 min kinetics, easy recovery, and successful remediation. Abstract The presence of endocrine‐disrupting compounds, such as 17‐β‐estradiol, in aquatic ecosystems poses a significant ...
Dante S Silva   +10 more
wiley   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre   +5 more
wiley   +1 more source

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