Results 51 to 60 of about 5,739 (107)

Evaluating putative lncRNA‐mediated ceRNA regulatory network involving miR396 and miR319 in maize leaf growth under Fusarium verticillioides infection

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
The final leaf length of maize (Zea mays) was reduced due to the pathogenic fungus Fusarium verticillioides infection as a result of increased expression of miR396 in the elongation zone and decreased expression of miR319 in the mature zone of maize leaves, leading to antagonistic regulation of the expression of the GRF15 and TCP38, respectively ...
Erdem Emre Deligoz, Fatma Aydinoglu
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, Volume 13, Issue 35, 24 June 2026.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

The expected utility and psychological impacts of exome sequencing results in the DDD‐Africa study

Journal of Genetic Counseling, Volume 35, Issue 3, June 2026.
Abstract Exome sequencing (ES) has become a valuable approach for diagnosing developmental disorders (DD), improving the diagnostic yield to up to 40%, and offering a potential end to the diagnostic odyssey experienced by many families. However, there remains a scarcity of studies assessing the lived experiences of parents and caregivers of individuals
Samantha Schnell, Zandisiwe Goliath, Barry Shingwenyana, Ingrid Smit, Bianca Rossouw, Monica Araujo, Elzette Gilfillan, Amanda Krause, Nadia Carstens, Zané Lombard, for the DDD‐Africa Research Group, as members of The H3Africa Consortium   +11 more
wiley   +1 more source

Prenatal Tympanic Ring Anomaly Without Microtia: A Subtle Clue Toward Severe Early‐Onset Monogenic Disorders

Prenatal Diagnosis, Volume 46, Issue 7, Page 1096-1103, June 2026.
ABSTRACT Objective To investigate the genetic etiologies and clinical significance of fetal tympanic ring abnormalities detected during second‐trimester ultrasound in the absence of microtia. Method Between November 2019 and June 2024, we examined the fetal tympanic rings of 10,277 unselected pregnant women during the 20–22 weeks of morphology ...
Yung Hang Lam, Mengmeng Shi, Zirui Dong, Kwong Wai Choy, Tak Yeung Leung, Ye Cao   +5 more
wiley   +1 more source

Rapid diagnosis of pseudomosaicism in a case of Level II mosaicism for trisomy 5 in a single colony from an in situ culture of amniocytes and a review of mosaic trisomy 5 at amniocentesis

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: We present prenatal diagnosis of pseudomosaicism for trisomy 5 and a review of the literature of mosaic trisomy 5 at amniocentesis. Case Report: A 39-year-old woman underwent amniocentesis at 17 weeks of gestation, which revealed a karyotype ...
Chih-Ping Chen, Shing-Jyh Chang, Schu-Rern Chern, Peih-Shan Wu, Yen-Ni Chen, Shin-Wen Chen, Chien-Wen Yang, Chen-Wen Pan, Wayseen Wang   +8 more
doaj   +1 more source

Molecular characterization of CCKR in Ctenopharyngodon idella and its involvement in the intestinal immune response to bacterial challenges

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract Cholecystokinin receptor (CCKR), an important recognition receptor for the gastrointestinal hormone cholecystokinin (CCK) in the endocrine system, plays a crucial role in regulating immune responses in mammals. In this study, a novel cholecystokinin receptor (CiCCKR) was identified from the grass carp Ctenopharyngodon idella.
Ran Peng, Jingjing Yang, Huilan Mo, Miao Zhang, Xin Li, Xia Zhang, Meixing Guo, Kelan Jin, Fufa Qu, Jianzhong Li, Yunyun Zeng, Xixun Zhou, Zhuangwen Mao, Zhen Liu, Jianzhou Tang   +14 more
wiley   +1 more source

Cessation of Gene Flow Associated With the Reduction of a Sexually Selected Phenotype in the Island Stag Beetle

Molecular Ecology, Volume 35, Issue 12, June 2026.
ABSTRACT Whether gene flow acts as a creative or constraining force on local adaptation is a fundamental question in evolutionary biology, yet its role in the evolution of sexually selected traits remains poorly understood. Here we combine whole‐genome and functional analyses to investigate how geological isolation is associated with the evolution of ...
Kodai Kishino, Yusuke Oikawa, Takeshi Wakamiya, Kunio Araya, Tadatsugu Hosoya, Naoto Idogawa, Masafumi Nozawa, Takehiro K. Katoh, Yasukazu Okada   +8 more
wiley   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Chromosomal aberrations in pregnancy and fetal loss: Insight on the effect of consanguinity, review of 1625 cases

Molecular Genetics & Genomic Medicine, 2019
Background Pregnancy loss affects 10%–15% of pregnancies and is caused by several factors, maternal and fetal. Most common cause is chromosomal aneuploidy and has traditionally been detected by karyotyping product of conception and/or fetal tissue.
Kimia Najafi, Soheila Gholami, Azadeh Moshtagh, Masood Bazrgar, Neda Sadatian, Golemaryam Abbasi, Parvin Rostami, Soheila Khalili, Mojgan Babanejad, Bahareh Nourmohammadi, Negin Faramarzi Garous, Hossein Najmabadi, Roxana Kariminejad   +12 more
doaj   +1 more source