Results 61 to 70 of about 162,755 (120)

SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. [PDF]

PLoS Genetics, 2011
Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction.
Johanna Heideker, John Prudden, J Jefferson P Perry, John A Tainer, Michael N Boddy   +4 more
doaj   +1 more source

Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C

Genetics and Molecular Biology, 2011
A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation.
Lizcano Fernando, Romero Carolina, Diana Vargas   +2 more
doaj  

The frequency of CNVs in a cohort population of consecutive fetuses with congenital anomalies after the termination of pregnancy

Molecular Genetics & Genomic Medicine, 2019
Background The implementation of molecular karyotyping has resulted in an improved diagnostic yield in the genetic diagnostics of congenital anomalies, detected prenatally or after the termination of pregnancy.
Gorazd Rudolf, Luca Lovrečić, Nataša Tul, Nataša Teran, Borut Peterlin   +4 more
doaj   +1 more source

Whole genome sequencing reveals novel IGHMBP2 variant leading to unique cryptic splice‐site and Charcot‐Marie‐Tooth phenotype with early onset symptoms

Molecular Genetics & Genomic Medicine, 2019
Background Rare variants (RV) in immunoglobulin mu‐binding protein 2 (IGHMBP2) [OMIM 600502] can cause an autosomal recessive type of Charcot‐Marie‐Tooth (CMT) disease [OMIM 616155], an inherited peripheral neuropathy.
Thomas A. Cassini, Laura Duncan, Lynette C. Rives, John H. Newman, John A. Phillips, Mary E. Koziura, Jennifer Brault, Rizwan Hamid, Joy Cogan, Undiagnosed Diseases Network   +9 more
doaj   +1 more source

Scaling law for excitons in 2D perovskite quantum wells

Nature Communications, 2018
Ruddlesden–Popper halide perovskites are 2D solution-processed quantum wells with a general formula A2A’n-1MnX3n+1, where optoelectronic properties can be tuned by varying the perovskite layer thickness (n-value), and have recently emerged as efficient ...
J. Blancon, A. Stier, H. Tsai, H. Tsai, W. Nie, C. Stoumpos, Boubacar Traoré, L. Pédesseau, M. Képénekian, F. Katsutani, G. Noe, J. Kono, S. Tretiak, S. Crooker, C. Katan, M. Kanatzidis, J. Crochet, J. Even, A. Mohite, A. Mohite   +19 more
semanticscholar   +1 more source

470-Million-year-old black corals from China

Die Naturwissenschaften, 2012
Phosphatic (possibly secondarily phosphatised) remains of antipatharian coralla, previously unknown in the fossil record, occur abundantly in the early Ordovician Fenxiang Formation in the Hubei Province, southern China. Probably two species (and genera)
A. Baliński, Yuanlin Sun, J. Dzik
semanticscholar   +1 more source

Increase in the Contents of Ginsenosides in Raw Ginseng Roots in Response to Exposure to 450 and 470 nm Light from Light-Emitting Diodes

Journal of Ginseng Research, 2012
An light-emitting diode (LED)-based light source was used as a monochromatic light source to determine the responses of raw ginseng roots (Panax ginseng Meyer) to specific emission spectra with respect to the production of ginsenosides.
S. Park, Deok-Jong Ahn, H. Jeon, T. Kwon, Hyoun-Sub Lim, Bo-Seong Choi, K. Baek, Hanhong Bae   +7 more
semanticscholar   +1 more source

The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high fat fed mice

Obesity, 2012
The angiogenic inhibitor TNP‐470 attenuates high‐fat diet‐induced obesity; however, it is not clear how the compound alters energy balance to prevent weight gain.
H. White, A. Acton, R. Considine
semanticscholar   +1 more source

Description and comparison of growth parameters in Chianina and Nelore cattle breeds

Genetics and Molecular Biology, 1999
Weight data from birth to 18 months of age of Nelore and Chianina, both meat-producing cattle breeds, were analyzed. Data were corrected for significant effects of environment and utilized to estimate genetic parameters through the non-linear von ...
Carrijo Sônia Mara, Duarte Francisco A. Moura   +1 more
doaj  

The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial

European Respiratory Journal
Background Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH ...
J. Müller, Anna Titz, S. Schneider, M. Bauer, L. Mayer, L. Lüönd, T. Ulrich, M. Furian, A. Forrer, E. I. Schwarz, K. Bloch, M. Lichtblau, S. Ulrich   +12 more
semanticscholar   +1 more source