The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. [PDF]
Mobile group II introns are bacterial retrotransposons that are thought to have invaded early eukaryotes and evolved into introns and retroelements in higher organisms.
Travis B White, Alan M Lambowitz
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The date of interbreeding between Neandertals and modern humans. [PDF]
Comparisons of DNA sequences between Neandertals and present-day humans have shown that Neandertals share more genetic variants with non-Africans than with Africans.
Sriram Sankararaman +4 more
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There are increasing concerns regarding the impact of agrochemical pesticides on non-target organisms. Pesticides could cause honeybee abnormal development in response to neurotoxins such as neonicotinoid.
Kang Wang +9 more
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A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. [PDF]
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression
Xiaobing Luo +12 more
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SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. [PDF]
Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction.
Johanna Heideker +4 more
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Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution. [PDF]
Over 1.5 billion people lack the skeletal muscle fast-twitch fibre protein α-actinin-3 due to homozygosity for a common null polymorphism (R577X) in the ACTN3 gene.
Stewart I Head +7 more
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A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. [PDF]
Distal arthrogryposis type 2B (DA2B) is an important genetic disorder in humans. However, the mechanisms governing this disease are not clearly understood. In this study, we generated knock-in mice carrying a DA2B mutation (K175del) in troponin I type 2 (
Xiaoquan Zhu +20 more
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Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation.
Lizcano Fernando +2 more
doaj
Título: Ordenanças [et] prematicas hechas por Sus Altezas sobre los abogados [et] procuradores [et] derechos que han de lleuar alos pleyteantes [et] a los que se ygualaren durante el pleyto [et] las diligencias que han de hazer los abogados [et] procuradores ansi enla corte como enlos juycios particulares [PDF]
Peu d'impr. obtingut dels repertoris. Segons IBE: [Salamanca : Tip. de Nebrija: "Gramática", (Haeb. 470) (d. 26 junio, 1499]). Segons GW: [Salamanca: Drucker von Antonius Nebrissensis, Gramática castellana (GW 2224) (Antonius Nebrissensis?) für] Fernando
Jaén, Fernando de +1 more
core
Ritual fragments, tablet concordance KUB XVII 29 - CTH 470
Transcription of the ritual fragments based on tablet concordance KUB XVII 29 (inventory no. Bo 2424). Emmanuel Laroche translated this text as "Fragments de rituels,” and classified the concordance in the category of Anatolian magic in ritual texts ...
Gonnet-Bağana, Hatice
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