The date of interbreeding between Neandertals and modern humans. [PDF]
PLoS Genetics, 2012 Comparisons of DNA sequences between Neandertals and present-day humans have shown that Neandertals share more genetic variants with non-Africans than with Africans.
Sriram Sankararaman +4 more
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Frontiers in Genetics, 2018 There are increasing concerns regarding the impact of agrochemical pesticides on non-target organisms. Pesticides could cause honeybee abnormal development in response to neurotoxins such as neonicotinoid.
Kang Wang +9 more
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A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. [PDF]
PLoS Genetics, 2011 Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression
Xiaobing Luo +12 more
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SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability. [PDF]
PLoS Genetics, 2011 Through as yet undefined proteins and pathways, the SUMO-targeted ubiquitin ligase (STUbL) suppresses genomic instability by ubiquitinating SUMO conjugated proteins and driving their proteasomal destruction.
Johanna Heideker +4 more
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Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution. [PDF]
PLoS Genetics, 2015 Over 1.5 billion people lack the skeletal muscle fast-twitch fibre protein α-actinin-3 due to homozygosity for a common null polymorphism (R577X) in the ACTN3 gene.
Stewart I Head +7 more
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A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. [PDF]
PLoS Genetics, 2014 Distal arthrogryposis type 2B (DA2B) is an important genetic disorder in humans. However, the mechanisms governing this disease are not clearly understood. In this study, we generated knock-in mice carrying a DA2B mutation (K175del) in troponin I type 2 (
Xiaoquan Zhu +20 more
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Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C
Genetics and Molecular Biology, 2011 A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation.
Lizcano Fernando +2 more
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Description and comparison of growth parameters in Chianina and Nelore cattle breeds
Genetics and Molecular Biology, 1999 Weight data from birth to 18 months of age of Nelore and Chianina, both meat-producing cattle breeds, were analyzed. Data were corrected for significant effects of environment and utilized to estimate genetic parameters through the non-linear von ...
Carrijo Sônia Mara +1 more
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An elegans Solution for Crossover Formation. [PDF]
PLoS Genetics, 2013 Stephanie P Bellendir, Jeff Sekelsky
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