Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs. [PDF]
PLoS Genetics, 2013 The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it has also been shown that Elongator
Jorge Fernández-Vázquez +10 more
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Frontiers in Genetics, 2017 Several factors have been proposed as contributors to interfamilial and intrafamilial phenotypic variability in autosomal dominant disorders, including allelic variation, modifier genes, environmental factors and complex genetic and environmental ...
Baoheng Gui +3 more
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A model-based analysis of GC-biased gene conversion in the human and chimpanzee genomes. [PDF]
PLoS Genetics, 2013 GC-biased gene conversion (gBGC) is a recombination-associated process that favors the fixation of G/C alleles over A/T alleles. In mammals, gBGC is hypothesized to contribute to variation in GC content, rapidly evolving sequences, and the fixation of ...
John A Capra +4 more
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The struggle to find reliable results in exome sequencing data: Filtering out Mendelian errors
Frontiers in Genetics, 2014 Next Generation Sequencing studies generate a large quantity of genetic data in a relatively cost and time efficient manner and provide an unprecedented opportunity to identify candidate causative variants that lead to disease phenotypes.
Zubin Hasmukh Patel +20 more
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ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. [PDF]
PLoS Genetics, 2013 Zinc is an essential metal involved in a wide range of biological processes, and aberrant zinc metabolism is implicated in human diseases. The gastrointestinal tract of animals is a critical site of zinc metabolism that is responsible for dietary zinc ...
Hyun Cheol Roh +5 more
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Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels. [PDF]
PLoS Genetics, 2014 DNA methylation is an important epigenetic regulator of gene expression. Recent studies have revealed widespread associations between genetic variation and methylation levels.
Nicholas E Banovich +8 more
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Frontiers in Genetics, 2018 The commensal yeast Candida albicans is an opportunistic pathogen. In order to successfully colonize or infect the human body, the fungus must adapt to the host’s environmental conditions, such as low oxygen tension (hypoxia), temperature (37°C), and the
Thais F. Bartelli +4 more
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The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination. [PDF]
PLoS Genetics, 2012 Class-switch recombination (CSR), induced by activation-induced cytidine deaminase (AID), can be divided into two phases: DNA cleavage of the switch (S) regions and the joining of the cleaved ends of the different S regions.
Andre Stanlie +3 more
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Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. [PDF]
PLoS Genetics, 2012 Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing ...
He Gong +8 more
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The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. [PDF]
PLoS Genetics, 2012 Mobile group II introns are bacterial retrotransposons that are thought to have invaded early eukaryotes and evolved into introns and retroelements in higher organisms.
Travis B White, Alan M Lambowitz
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