Results 11 to 20 of about 162,755 (120)

CircFOXM1 acts as a ceRNA to upregulate SMAD2 and promote the progression of nasopharyngeal carcinoma

Molecular Genetics & Genomic Medicine, 2022
Background In recent years, the development of high‐throughput sequencing technology has promoted the rapid development of circRNA‐related research. Studies have found that circRNA plays a key role in a variety of tumors, but few people study the role of
Shuai Pei, Chengxian Ma, Jie Chen, Xinyu Hu, Mingyu Du, Tian Xu, Mengna Zhan, Ke Xue, Yufeng Zhang, Li Yin, Xia He   +10 more
doaj   +1 more source

Novel and recurrent nuclear gene variations in a cohort of Chinese progressive external ophthalmoplegia patients with multiple mtDNA deletions

Molecular Genetics & Genomic Medicine, 2022
Objectives This study aimed to investigate the clinical and genetic spectrum in Chinese patients with multiple mtDNA deletions presenting with autosomal‐inherited mitochondrial progressive external ophthalmoplegia (PEO).
Yue Hou, Xutong Zhao, Zhiying Xie, Meng Yu, He Lv, Wei Zhang, Yun Yuan, Zhaoxia Wang   +7 more
doaj   +1 more source

A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors.

European Journal of Cancer, 2020
BACKGROUND Adenoid cystic carcinoma (ACC) accounts for 1% of malignant head and neck tumours [1] and 10% of salivary glands malignant tumours. The main objective of our study is to investigate the prognostic factors influencing the event-free survival ...
S. Atallah, O. Casiraghi, N. Fakhry, M. Wassef, E. Uro-Coste, F. Espitalier, A. Sudaka, M. Kaminsky, S. Dakpé, L. Digue, O. Bouchain, S. Morinière, M. Hourseau, C. Bertolus, F. Jegoux, J. Thariat, V. Calugaru, P. Schultz, P. Philouze, O. Mauvais, C. Righini, C. Badoual, N. Saroul, J. Goujon, J. Marie, R. Taouachi, E. Brenet, A. Aupérin, B. Baujat   +28 more
semanticscholar   +1 more source

Evaluation of novel compound variants of CEP290 in prenatally suspected case of Meckel syndrome through whole exome sequencing

Molecular Genetics & Genomic Medicine, 2022
Background Meckel syndrome (MKS) is a fatal disease characterized by multisystem fibrosis during the prenatal or perinatal period. It has an autosomal recessive genetic pattern and is characterized by meningo occipital encephalocele, polycystic kidney ...
Meilian Peng, Shuai Han, Juan Sun, Xiaodong He, Yaer Lv, Liwei Yang   +5 more
doaj   +1 more source

Patient characteristics and predictors of mortality in 470 adults admitted to a district general hospital in England with Covid-19

Epidemiology and Infection, 2020
Understanding risk factors for death from Covid-19 is key to providing good quality clinical care. We assessed the presenting characteristics of the ‘first wave’ of patients with Covid-19 at Royal Oldham Hospital, UK and undertook logistic regression ...
J. Thompson, N. Meghani, B. Powell, I. Newell, R. Craven, G. Skilton, L. J. Bagg, I. Yaqoob, M. Dixon, E. Evans, B. Kambele, Aziz Ur Rehman, G. Ng Man Kwong   +12 more
semanticscholar   +1 more source

PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+

Aging, 2020
The neurotoxin MPP+ (1-methyl-4-phenylpyridinium ion) disrupts mitochondrial function leading to oxidative stress and neuronal death. Here we examine whether activation of the Keap1-Nrf2 cascade can protect SH-SY5Y neuroblastoma cells from MPP+-induced ...
Jin-yu Zheng, Jian-liang Zhu, Yufeng Zhang, Hao Zhang, Yu Yang, De-Rong Tang, Jian Sun   +6 more
semanticscholar   +1 more source

The histone variant H2A.Z in gene regulation

Epigenetics & Chromatin, 2019
The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer.
Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake, Tilman Borggrefe   +4 more
doaj   +1 more source

The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin.

Biochemical Pharmacology, 2020
The therapeutic mechanism of action of methionine aminopeptidase 2 (MetAP2) inhibitors for obesity-diabetes has not yet been fully defined. Xenin, a K-cell derived peptide hormone, possesses an N-terminal Met amino acid residue.
S. Craig, V. Gault, P. Flatt, N. Irwin
semanticscholar   +1 more source

Deep 230-470 MHz VLA observations of the mini-halo in the Perseus cluster [PDF]

, 2017
We present a low-frequency view of the Perseus cluster with new observations from the Karl G. Jansky Very Large Array (JVLA) at 230–470 MHz. The data reveal a multitude of new structures associated with the mini-halo. The mini-halo seems to be influenced
M. Gendron-Marsolais, J. Hlavacek-Larrondo, R. Weeren, Tracy E. Clarke, A. Fabian, H. Intema, G. Taylor, K. Blundell, J. Sanders   +8 more
semanticscholar   +1 more source

Genome-Wide Characterization of Alternative Splicing Events and Their Responses to Cold Stress in Tilapia

Frontiers in Genetics, 2020
Alternative splicing (AS) is an important post-transcriptional regulatory mechanism for cells to generate transcript variability and proteome diversity.
Bi Jun Li, Zong Xian Zhu, Hui Qin, Zi Ning Meng, Hao Ran Lin, Jun Hong Xia   +5 more
doaj   +1 more source