Results 11 to 20 of about 56,475 (99)

Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization

Cellular & Molecular Biology Letters, 2022
Background EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR monoclonal antibodies (moAbs ...
Donatella Romaniello, Valerio Gelfo, Federica Pagano, Enea Ferlizza, Michela Sgarzi, Martina Mazzeschi, Alessandra Morselli, Carmen Miano, Gabriele D’Uva, Mattia Lauriola   +9 more
doaj   +1 more source

Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

Journal of Orthopaedic Surgery and Research, 2022
Background Circular RNAs (circRNAs) have emerged as vital regulators in the development of rheumatoid arthritis (RA). In this study, we aimed to explore the functions and mechanisms of circ_0001947 in RA.
Yang Yang, Shudian Lin, Zhou Yang, Yanyan Huang, F. Zhan   +4 more
semanticscholar   +1 more source

Extracellular ATP promotes breast cancer chemoresistance via HIF-1α signaling

Cell Death and Disease, 2022
We have previously demonstrated that extracellular adenosine 5'-triphosphate (ATP) promotes breast cancer cell chemoresistance. However, the underlying mechanism remains unclear.
Hui Yang, Yue-Hang Geng, Peng Wang, Hong-Quan Zhang, Wei-Gang Fang, Xin-Xia Tian   +5 more
doaj   +1 more source

Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance

Cell Death and Disease, 2022
Increased glycolysis is a hallmark of tumor, which can provide tumor cells with energy and building blocks to promote cell proliferation. Recent studies have shown that not only the expression of glycolytic genes but also their subcellular localization ...
Peng Liu, Si-Jia Sun, Ying-Jie Ai, Xu Feng, Yi-Min Zheng, Yun Gao, Jin-Ye Zhang, Lei Zhang, Yi-Ping Sun, Yue Xiong, Miao Lin, Hai-Xin Yuan   +11 more
doaj   +1 more source

Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis

Cell Death and Disease, 2022
Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown.
Tao Han, Hao Zheng, Jin Zhang, Pinghua Yang, Hengyu Li, Zhangjun Cheng, Daimin Xiang, Ruoyu Wang   +7 more
doaj   +1 more source

Molecular basis of apoptotic DNA fragmentation by DFF40

Cell Death and Disease, 2022
Although the functions of CIDE domain-containing proteins, including DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, in apoptotic DNA fragmentation and lipid homeostasis have been studied extensively in mammals, the functions of four CIDE domain-containing ...
Hyun Ji Ha, Hyun Ho Park
doaj   +1 more source

MiR‐671‐5p sponging activity of circMMP1 promotes esophageal squamous cancer progression

Thoracic Cancer, 2023
The aim of this study was to explore the function and mechanism of circular RNA (circRNA) matrix metallopeptidase 1 (circMMP1) in the progression of esophageal squamous cell carcinoma (ESCC).
Rong Li, Linyan Chai, Lei Lei, Rong Guo, Xiulin Wen   +4 more
semanticscholar   +1 more source

Purity and yield of melanoma exosomes are dependent on isolation method

Journal of Extracellular Vesicles, 2020
Both exosomes and soluble factors have been implicated in the generation of an immunosuppressive tumour microenvironment. Determining the contribution of each requires stringent control of purity of the isolated analytes.
Shin La Shu, Yunchen Yang, Cheryl L. Allen, Edward Hurley, Kaity H. Tung, Hans Minderman, Yun Wu, Marc S. Ernstoff   +7 more
doaj   +1 more source

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang, Jiafeng Liu, Xiaoyao Zhang, Qiyan Chen, Xiao-yan Bai, Xue Hong, Lili Zhou, Youhua Liu   +7 more
semanticscholar   +1 more source

Exosomal PD-L1 functions as an immunosuppressant to promote wound healing

Journal of Extracellular Vesicles, 2020
Excessive and persistent inflammation after injury lead to chronic wounds, increased tissue damage or even aggressive carcinogenic transformation. Effective wound repair could be achieved by inhibiting overactive immune cells to the injured site. In this
Dandan Su, Hsiang-I Tsai, Zhanxue Xu, Fuxia Yan, Yingyi Wu, Youmei Xiao, Xiaoyan Liu, Yanping Wu, Sepideh Parvanian, Wangshu Zhu, John E. Eriksson, Dongqing Wang, Haitao Zhu, Hongbo Chen, Fang Cheng   +14 more
doaj   +1 more source