Results 21 to 30 of about 56,475 (99)

Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog

BMC Molecular and Cell Biology, 2021
Background Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquinone in the mitochondrial electron ...
Aloka B. Bandara, Joshua C. Drake, David A. Brown   +2 more
doaj   +1 more source

Dual Targeting of Angipoietin‐1 and von Willebrand Factor by microRNA‐671‐5p Attenuates Liver Angiogenesis and Fibrosis

Hepatology Communications, 2022
Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study.
Le Yang, W. Yue, Hang Zhang, Zhi Zhang, Renmin Xue, C. Dong, Fuquan Liu, N. Chang, Lin Yang, Liying Li   +9 more
semanticscholar   +1 more source

lncRNA DLEU1 Modulates Proliferation, Inflammation, and Extracellular Matrix Degradation of Chondrocytes through Regulating miR-671-5p

Journal of Immunological Research, 2022
Long noncoding RNAs (lncRNAs) have been shown to be involved in the development of osteoarthritis. However, the expression, function, and mechanism of DLEU1 in OA development remain largely unclear.
Xiangkun Wu, Shuai Yin, Lihua Yan, Yongxi Liu, L. Shang, Jun Liu   +5 more
semanticscholar   +1 more source

PURPL represses autophagic cell death to promote cutaneous melanoma by modulating ULK1 phosphorylation

Cell Death and Disease, 2021
Uncontrolled overactivation of autophagy may lead to autophagic cell death, suppression of which is a pro-survival strategy for tumors. However, mechanisms involving key regulators in modulating autophagic cell death remain poorly defined.
Shuo Han, Xue Li, Ke Wang, Dingheng Zhu, Bingyao Meng, Jieyu Liu, Xiaoting Liang, Yi Jin, Xingyuan Liu, Qian Wen, Liang Zhou   +10 more
doaj   +1 more source

Circ_0043947 contributes to interleukin 1β-induced injury in chondrocytes by sponging miR-671-5p to up-regulate RTN3 expression in osteoarthritis pathology

Journal of Orthopaedic Surgery and Research, 2022
Objective Osteoarthritis (OA) is a chronic joint disease featured by articular cartilage degeneration and damage. Accumulating evidence have demonstrated the pivotal regulatory roles of circular RNAs in OA pathology.
Min He, Zhihe Jia, Yiying Wen, Xiaolin Chen   +3 more
semanticscholar   +1 more source

The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression

Cellular & Molecular Biology Letters, 2021
Background Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many cancers.
Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou, Erhao Zhang   +9 more
doaj   +1 more source

Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma

Annals of Translational Medicine, 2022
Background Circular RNAs (circRNAs) are a newly described class of non-coding RNAs that play essential roles in regulating gene expression. However, to date, few studies have examined the roles of circRNAs in papillary thyroid carcinoma (PTC).
Xiaoyu Liu, Congren Wang, Zijian Su, Shao-Qing Cai, Qunxiong Pan, Xiangjin Chen   +5 more
semanticscholar   +1 more source

Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1

Cell Death and Disease, 2021
Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells.
Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu, Yuling Li   +13 more
doaj   +1 more source

Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models

Journal of Extracellular Vesicles, 2019
Liver constitutes the major metabolic factory in the organism and is involved in the synthesis, secretion and clearance of many blood-circulating molecules.
Felix Royo, David Gil-Carton, Esperanza Gonzalez, Justyna Mleczko, Laura Palomo, Miriam Perez-Cormenzana, Rebeca Mayo, Cristina Alonso, Juan M. Falcon-Perez   +8 more
doaj   +1 more source

FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila

Cell Death and Disease, 2021
Target of Rapamycin Complex 1 (TORC1) is a master regulator that coordinates nutrient status with cell metabolism. The GTPase-activating protein towards Rags complex 1 (GATOR1) inhibits TORC1 activity and protects cells from damage during periods of ...
Ying Zhou, Jian Guo, Xinyu Wang, Yang Cheng, Jianwen Guan, Priyam Barman, Ming-An Sun, Yuanyuan Fu, Wanhong Wei, Congjing Feng, Mary A. Lilly, Youheng Wei   +11 more
doaj   +1 more source