Results 21 to 30 of about 5,286 (173)
Decreased plasma Aβ in hyperlipidemic APPSL transgenic mice is associated with BBB dysfunction
Frontiers in Neuroscience, 2016 Besides the continued focus on Aβ and Tau in Alzheimer’s disease (AD), it is increasingly evident that other pathologic characteristics, such as vascular alterations or inflammation, are associated with AD.
Tina eLöffler +3 more
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CURRENT ALGEBRAS AND QP-MANIFOLDS [PDF]
International Journal of Geometric Methods in Modern Physics, 2013 Generalized current algebras introduced by Alekseev and Strobl in two dimensions are reconstructed by a graded manifold and a graded Poisson brackets. We generalize their current algebras to higher dimensions. QP-manifolds provide the unified structures of current algebras in any dimension.
Ikeda, Noriaki, Koizumi, Kozo
openaire +2 more sources
Phosphorylation of different tau sites during progression of Alzheimer’s disease
Acta Neuropathologica Communications, 2018 Alzheimer’s disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. Tau phosphorylation causes formation of neurofibrillary tangles and neuropil threads.
Joerg Neddens +9 more
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Hepatic and neuronal phenotype of NPC1−/− mice
Heliyon, 2019 Niemann-Pick type C disease (NPC) is a fatal autosomal recessive disorder characterized by a defect in the intracellular transport of lipoproteins leading to the accumulation of lipids in diverse tissues. A visceral and neuronal phenotype mimicking human
Estibaliz Santiago-Mujica +5 more
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Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer
European Clinical Respiratory Journal, 2020 In 1960s, cromolyn sodium (CS) has been introduced as the first non-steroidal anti-inflammatory drug for the treatment of allergic and mast-cell driven diseases. Its applicability has been limited due to a poor bioavailability.
Khalid Abd-Elaziz +2 more
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Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase
Medicine in Drug Discovery, 2020 Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan +7 more
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Clinical Neurophysiology Practice, 2023 Objective: This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy. Methods: Four patients were included in the study.
Setsu Nakatani-Enomoto +13 more
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Gal(Qp/Qp) as a geometric fundamental group [PDF]
International Mathematics Research Notices, 2016 Let p be a prime number. In this article we present a theorem, suggested by Peter Scholze, which states that Gal(Qp/Qp) is the etale fundamental group of certain object Z which is defined over an algebraically closed field. As a consequence, p-adic representations of Gal(Qp/Qp) correspond to Qp-local systems on Z.
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Blueprints in biochemistry: Systematic assessment in undergraduate medical education [PDF]
Research and Development in Medical Education, 2022 Background: The traditional pattern of theory assessment may not address the principles of assessment due to faulty paper-setting practices. This interventional study aimed to sensitize the faculty in designing a test blueprint template to set question ...
Yogesh R. Pawade +2 more
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Clinical and Translational Science, 2020 In vitro studies have indicated that the P2Y12 receptor antagonist selatogrel is a substrate of organic anion‐transporting‐polypeptide (OATP)1B1 and OATP1B3 that are known to mediate hepatic uptake.
Uta Schilling +5 more
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