Results 71 to 80 of about 2,601,171 (128)

Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report

Biomolecules
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge.
Jassim M. Al-Hassan, Waleed M. Renno, Sosamma Oommen, Divya Nair, Bincy Maniyalil Paul, Bincy Mathew, Jijin Kumar, Afna Ummerkutty, Cecil Pace-Asciak   +8 more
doaj   +1 more source

The Link Between Endoplasmic Reticulum Stress and Lysosomal Dysfunction Under Oxidative Stress in Cancer Cells

Biomolecules
Lysosomal dysfunction and endoplasmic reticulum (ER) stress play essential roles in cancer cell survival, growth, and stress adaptation. Among the various stressors in the tumor microenvironment, oxidative stress (OS) is a central driver that exacerbates
Mariapia Vietri, Maria Rosaria Miranda, Giuseppina Amodio, Tania Ciaglia, Alessia Bertamino, Pietro Campiglia, Paolo Remondelli, Vincenzo Vestuto, Ornella Moltedo   +8 more
doaj   +1 more source

Ultrastructural Aspects of Physiological Mineralization: A Comparative Study in Different Hard Tissues

Biomolecules
The calcified tissues of vertebrates are essentially represented by bone, cartilage, dentin and calcified tendons. In all these tissues a major hallmark of mineralization is the deposition of the inorganic phase on a pre-existing collagen template, but ...
Marina Borgese, Mario Raspanti, Marina Protasoni, Piero Antonio Zecca, Fulvia Ortolani, Marcella Reguzzoni   +5 more
doaj   +1 more source

Disrupting SARS-CoV-2 Spike–ACE2 Interactions via Glycosaminoglycans in a Pseudoviral Study of Heparan Sulfate and Enoxaparin

Biomolecules
Background: The COVID-19 (coronavirus disease 19) pandemic has underscored the urgent need for effective antiviral agents targeting viral entry mechanisms.
Virginia Fuochi, Salvatore Furnari, Filippo Drago, Pio Maria Furneri   +3 more
doaj   +1 more source

CBS 502 [PDF]

, 1980
This one minute audio recording is by Landon Brady Saunders and is titled CBS 502.
Saunders, Landon Brady
core  

Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase

Biomolecules
DYRK1A kinase is a critical regulator in cellular signaling pathways and a promising therapeutic target for neurodegenerative diseases, diabetes and cancers.
Jin Jin, Qihong Zhou, Bin Guo, Zongchao Jia   +3 more
doaj   +1 more source

In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones

, 2015
Quinones are highly reactive molecules that readily undergo either one- or two-electron reduction. One-electron reduction of quinones or their derivatives by enzymes such as cytochrome P450 reductase or other flavoproteins generates unstable semiquinones,
Gayon, Régis, Gayon, R., Antoine, M., Nepveu, Françoise, Boutin, J. A., Cassagnes, Laure-Estelle, Moulharat, Natacha, Nepveu, F., Reybier, Karine, Ferry, G., Perio, Pierre, Boutin, Jean A., Ferry, Gilles, Cassagnes, L. E., Moulharat, N., Reybier, K., Antoine, Mathias   +16 more
core   +1 more source

Hepatic Lipoprotein Metabolism: Current and Future In Vitro Cell-Based Systems

Biomolecules
Changes in hepatic lipoprotein metabolism are responsible for the majority of metabolic dysfunction-associated disorders, including familial hypercholesterolemia (FH), metabolic syndrome (MetS), metabolic dysfunction-associated fatty liver disease (MAFLD)
Izabella Kiss, Nicole Neuwert, Raimund Oberle, Markus Hengstschläger, Selma Osmanagic-Myers, Herbert Stangl   +5 more
doaj   +1 more source

Heparin-Binding Hemagglutinin-Induced Trained Immunity in Macrophages: Implications for Antimycobacterial Defense

Biomolecules
Tuberculosis (TB) is a major global health threat, with the current Bacillus Calmette–Guérin (BCG) vaccine having limited efficacy against adult pulmonary disease.
Yongqiang Li, Xiuping Jia, Jinhua Tang, Huilian Qiao, Jiani Zhou, Yueyun Ma   +5 more
doaj   +1 more source

Quiescence Multiverse

Biomolecules
Cellular quiescence is operationally defined as a temporary and reversible cessation of proliferation. This state encompasses a wide range of physiological situations since most cells, from microbes to cells composing complex tissues, spend most of their
Damien Laporte, Isabelle Sagot
doaj   +1 more source