Results 231 to 240 of about 1,617,447 (322)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Key regulatory genes in sugar beet's defense against curly top virus identified by network analysis and qRT-PCR. [PDF]

Biochem Biophys Rep
Porameri Z, Ghorbani A, Mirsoleymani Z, Karimi M, Rostami M, Hemmati SA.   +5 more
europepmc   +1 more source

Reporter Gene-Based qRT-PCR Assay for Rho-Dependent Termination In Vivo. [PDF]

Cells, 2023
N MPA, Jeon H, Wang X, Lim HM.
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Identification of stable reference genes for qRT-PCR in Stropharia rugosoannulata using mRNA-sequencing data. [PDF]

PLoS One
Zhang X, Li X, Hua R, Fang Y, Yue T, Li J, Lu Y, Yue W, Gao Z, Liu S, Sun D.   +10 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Comparison of qRT-PCR and ddPCR for multi-strain probiotic detection after a randomized human clinical trial. [PDF]

Front Microbiol
Yeung N, Ouwehand AC.
europepmc   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

An integrated methodological framework for the validation and verification of clinical testing by qRT-PCR. [PDF]

Heliyon
Cardona-Ramírez C, Enríquez-Valencia CE, Méndez-Callejas G, Barreto GM, Tafur-Gómez GA, Sanjuanelo-Corredor DW.   +5 more
europepmc   +1 more source

SaliVIR COVID19 Rapid Multiplex qRT-PCR Kit v1

, 2020
Daniel Elias Martin-Herranz, Thomas Stubbs   +1 more
openaire   +1 more source