Results 71 to 80 of about 16,010 (186)
ChemFoodChem, Volume 2, Issue 2, June 2026.ABSTRACT Engineered nanomaterials (ENMs) are increasingly applied in agriculture to improve crop yield, nutrient efficiency, and food quality. This study examines the environmental transformation of ENMs, their uptake in plants, and their transfer across the agri‐food chain leading to human exposure.
Soumitra Nath
wiley +1 more source
Computer prediction of toxicity of new S-alkyl derivatives of 1,2,4-triazole
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki1,2,4-Triazole derivatives are of researchers’ significant interest due to their diverse biological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant activities.
V. V. Kalchenko, R. O. Shcherbyna
doaj +1 more source
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
Quantum chemistry parameters in QSAR toxicity studies of anilines(量子化学参数用于苯胺类化合物的QSAR毒性研究)
Zhejiang Daxue xuebao. Lixue ban, 2003 采用了ChemOffice6.0中MOPAC-AMl量子化学法计算了24种苯胺类化合物的6种量子化学参数,其中取17个化合物作为样本集对pEC50进行多元逐步回归分析,得到最佳方程:经自由度校正的回归系数R=0.985.应用所建立的QSAR模型验证了苯胺类化合物的EC50值,并通过"Jackknife"法中逐一抽取法进行模型检验,验证了该模型具有很好的稳定性,平均残差仅为0.05个对数单位,小于文献值.经过7个预测样本对该模型进行验证,结果表明该模型具有很好的预测能力,并分析了苯胺类化合物的毒性机理.
PEIHong-ping(裴洪平) +1 more
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ChemistrySelect, Volume 11, Issue 21, 4 June 2026.Water activity (aw) was measured in eight DESs (10–90 wt% water). Strong DES–water interactions persist to ∼50 wt%, after which structure collapses toward aqueous‐like behavior. Redlich–Kister, Wilson, and COSMO‐RS models showed limited performance, whereas QSAR modeling using COSMOtherm‐derived σ‐profile descriptors significantly improved aw ...
Marko Rogošić +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 12, Page 3377-3394, June 2026.IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand +8 more
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Jurnal Kimia Sains dan AplikasiBreast cancer is one of the most problematic diseases in the world. Currently, there are no potential vaccines for the treatment of this disease. Therefore, finding effective compounds, such as curcumin analogs, is crucial to inhibit breast cancer. Forty-
Neni Frimayanti, Adel Zamri, Yum Eryanti
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Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis +7 more
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Reviews in Aquaculture, Volume 18, Issue 3, June 2026.ABSTRACT Monogeneans are among the most problematic ectoparasites in finfish aquaculture. Plant‐derived compounds have been widely explored as therapeutic agents, yet their efficacy and safety have not been quantitatively synthesized across studies. This study provides a meta‐analysis of plant‐based treatments against monogeneans, integrating 453 in ...
Francisco Neptalí Morales‐Serna
wiley +1 more source