Results 81 to 90 of about 17,150 (158)

Peer review of the pesticide risk assessment of the active substance fatty acids from hydrolysed vegetable oils

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Greece, and co‐rapporteur Member State, Austria, for the pesticide active substance fatty acids from hydrolysed vegetable oils are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Teresa Chavez Capilla, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Julia Fabrega, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza, Amarela Becirovic, Galini Mavriou   +49 more
wiley   +1 more source

Updated Scientific Opinion on the risks for animal and human health related to the presence of phomopsins in feed and food

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract The EFSA CONTAM Panel assessed the risks for animal and human health related to the presence of phomopsins in feed and food. Lupins are considered the main source of phomopsins. Since the previous CONTAM Panel 2012 Opinion on phomopsins, new studies investigated the structural diversity of phomopsins.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Vasileios Bampidis, Guido Rychen, Ronald Maul, Edoardo Carnesecchi, Jean‐Lou Dorne, Petra Gergelová, Eirini Kouloura, Elena Rovesti, Lydia Alarcón Asensio, Sofie Schryvers, Chantra Eskes   +28 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of xylanase (produced with Komagataella phaffii DSM 25376) and beta‐glucanase (produced with Komagataella phaffii DSM 26469) (ENZY CARBOPLUS®) for all porcine species for fattening and reared for reproduction (Kaesler Nutrition GmbH)

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of xylanase (produced with Komagataella phaffii DSM 25376) and β‐glucanase (produced with K. phaffii DSM 26469) (ENZY CARBOPLUS®) as a zootechnical feed additive (functional group: digestibility enhancers).
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Noël Dierick, Montserrat Anguita, Matteo Lorenzo Innocenti, Jordi Ortuño, Maria Mountricha   +21 more
wiley   +1 more source

Screening benzimidazole derivatives for atypical antipsychotic activity

Фармация и фармакология (Пятигорск)
The development of innovative antipsychotic drugs is one of the key tasks of modern pharmacology. Due to their unique chemical properties, benzimidazole derivatives demonstrate diverse neuropsychotropic effects, highlighting their high potential as ...
K. Yu. Kalitin, O. Yu. Mukha, V. B. Voynov   +2 more
doaj   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Development and validation of DSTOX: an integrated QSAR platform adhering to ICH M7 guidelines for mutagenicity assessment of drug impurities

Acta Materia Medica
The assessment of a compound’s potential DNA reactivity (mutagenicity) is a critical component of its safety evaluation. The biological activity of a compound is generally understood to be closely associated with its chemical structure.
Guo Yu, Tiantian Xu, Siyao Fan, Zejian Zhou, Jinqi Zheng   +4 more
doaj   +1 more source

QSAR prediction of toxicity for a new 1,2,4-triazole derivatives with 2-bromo-5-methoxyphenyl fragment

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
New derivatives of 1,2,4-triazole are promising research targets due to their unique biological properties, including antimicrobial, antifungal, antitumor, and antioxidant activities.
M. P. Skoryi, R. O. Shcherbyna
doaj   +1 more source

3D-QSAR studies of 4-aminoquinoline-pyrimidine hybrids as antimalarial inhibitors targeting wild-type P. falciparum dihydrofolate reductase

Songklanakarin Journal of Science and Technology (SJST)
Three-dimensional quantitative structure–activity relationship (3D-QSAR) was determined on a set of 4- aminoquinoline-pyrimidine hybrids to elucidate the 3D structural features affecting the antimalaria activity against wild-type Plasmodium falciparum ...
Jitrayut Jitonnom, Wijitra Jitonnom, Panthip Tue-ngeun, Patchreenart Saparpakorn, Supa Hannongbua, Warot Chotpatiwetchkul   +5 more
doaj  

2D/3D-QSAR-guided design of novel 1,2,4-triazole derivatives with predicted enhanced antimicrobial activity. [PDF]

RSC Adv
Korol N, Mulesa O, Symkanych O, Slyvka M.   +3 more
europepmc   +1 more source

QSAR and Free-Wilson Analysis of Bioisosteric Derivatives of Dimebon to Optimize the Search for Potential Inhibitors of Mitochondrial Permeability Transition. [PDF]

Molecules
Veselov IM, Zverev DV, Shulga DA, Aksinenko AY, Milaeva ER, Fisenko VP, Shevtsova EF, Bachurin SO.   +7 more
europepmc   +1 more source