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The prolongation of the QT interval is a relatively rare but serious adverse drug reaction. It can lead to torsade de pointes, which is potentially life-threatening.
V. Buss+4 more
semanticscholar +1 more source
Functional data analytic approach of modeling ECG T-wave shape to measure cardiovascular behavior [PDF]
The T-wave of an electrocardiogram (ECG) represents the ventricular repolarization that is critical in restoration of the heart muscle to a pre-contractile state prior to the next beat. Alterations in the T-wave reflect various cardiac conditions; and links between abnormal (prolonged) ventricular repolarization and malignant arrhythmias have been ...
arxiv +1 more source
Prolonged QT interval: A tricky diagnosis? [PDF]
Prolonged heart-rate adjusted QT intervals on the electrocardiogram (ECG) are associated with an increased risk far coronary heart disease and sudden death. However, the diagnosis of the prolonged QT interval is hampered by lack of standards.
Bemmel, J.H. (Jan) van+6 more
core +1 more source
Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity
AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy (CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as
Elias Tsiompanidis+7 more
semanticscholar +1 more source
Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason+2 more
wiley +1 more source
Spectral-Efficiency of Cell-Free Massive MIMO with Multicarrier-Division Duplex [PDF]
A multicarrier-division duplex (MDD)-based cell-free (CF) scheme, namely MDD-CF, is proposed, which enables downlink (DL) data and uplink (UL) data or pilots to be concurrently transmitted on mutually orthogonal subcarriers in distributed CF massive MIMO (mMIMO) systems. To demonstrate the advantages of MDD-CF, we firstly study the spectral-efficiency (
arxiv +1 more source
QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization
The effects of isavuconazole (active moiety of isavuconazonium sulfate) on cardiac ion channels in vitro and cardiac repolarization clinically were assessed in a phase I, randomized, double‐blind study in healthy individuals who received isavuconazole ...
J. Keirns+11 more
semanticscholar +1 more source
A Data-Driven Gaussian Process Filter for Electrocardiogram Denoising [PDF]
Objective: Gaussian Processes (GP)-based filters, which have been effectively used for various applications including electrocardiogram (ECG) filtering can be computationally demanding and the choice of their hyperparameters is typically ad hoc. Methods: We develop a data-driven GP filter to address both issues, using the notion of the ECG phase domain
arxiv
QT Interval in Pregnant and Non-pregnant Women [PDF]
Introduction: Prolongation of QT interval might result in dangerous cardiac arrhythmias, including Torsades de Pointes (TdP), consequently leading to syncope or death.
Esmailian, Mehrdad+2 more
core +3 more sources
Background: Several reports have demonstrated that prolongation of the QT interval is associated with sudden cardiac death (SCD). However, it is unknown whether any of the components within the QT interval are responsible for its association with SCD ...
Wesley T. O’Neal+7 more
semanticscholar +1 more source