Results 71 to 80 of about 182,594 (345)

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal
Zahit Çeker, Suna Akin Takmaz, Bülent Baltaci, Hülya Basar   +3 more
doaj   +1 more source

QTc interval measurement in patients with right bundle branch block: A practical method

Annals of Noninvasive Electrocardiology, 2023
Background and Aim Prolonging the QT interval in the right bundle branch block (RBBB) can create challenges for electrophysiologists in estimating repolarization time and eliminating the effect of depolarization changes on QT interval.
Abolfath Alizadeh, Mohammad Amin Shahrbaf, Mohammadrafie Khorgami, Mahboubeh Zeighami, Ala Keikhavani, Hamid Mokhtari Torshizi, Zahra Teimouri‐jervekani   +6 more
doaj   +1 more source

Effect of sotalol on heart rate, QT interval, and atrial fibrillation cycle length in horses with atrial fibrillation [PDF]

, 2018
Background: Based on its pharmacokinetic profile and electrophysiological effects in healthy horses, sotalol potentially could be used as a long-term PO antiarrhythmic drug in horses.
Anderson, Barrell, Brakel, Broux, Broux, Campbell, Clercq, Clercq, Clercq, Decloedt, Decloedt, Decloedt, Deem, Dufourni, Haugaard, Heliczer, January, Kerin, Lafuente-Lafuente, Loon, Mansour, McGurrin, Meurs, Milan, Pedersen, Rasmussen, Reef, Reef, Verheyen, Wang, Wijffels, Wijffels   +31 more
core   +2 more sources

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Reliability of the electrocardiogram in normal rats [PDF]

, 2012
Several electrocardiogram (ECG) indexes are used to identify cardiac abnormalities in rats. However, there are few studies about the reliability of this tool.
Areas, Miguel Arcanjo, Macedo, Denise Vaz de, Oliveira, Renato Buscariolli de, Santos, Gustavo Barbosa   +3 more
core   +1 more source

Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases [PDF]

, 2011
In order to begin searching for new markers for safe exercise training in patients with cardiac diseases, we tested the sensitivity and reliability of the short-term variability of repolarization (STVQT) in comparison with QT interval, QTc, and Tpeak ...
Aonuma Kazutaka, Enomoto Tsuyoshi, Igawa Masayuki, Iida Kaname, Koseki Susumu, Kuroki Kenji, Nishi Isao, Sugiyama Atsushi, Takahara Akira, 西 功, 青沼 和隆   +10 more
core   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source