Drug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction. [PDF]
PLoS ONEHeart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced QT interval prolongation. It is unknown if HF with preserved ejection fraction (HFpEF) is also associated with an increased risk.
Chien-Yu Huang +5 more
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QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine [PDF]
Therapeutic Advances in Drug Safety, 2020 Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer’s disease (AD). This study aimed to evaluate evidence from the case report literature for an association between these ...
Katie Malone, Jules C. Hancox
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Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation. [PDF]
Int J Mol Sci, 2021 Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus ...
Baracaldo-Santamaría D +6 more
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A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS [PDF]
Frontiers in Cardiovascular MedicinePurposeTo identify the most commonly reported drugs associated with QT interval prolongation in the FDA Adverse Event Reporting System (FAERS) and evaluate their risk for QT interval prolongation.MethodsWe employed the preferred term (PT ...
Haowen Tan +9 more
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Association Between Disturbed Serum Phosphorus Levels and QT Interval Prolongation [PDF]
Kidney International ReportsIntroduction: QT interval prolongation is a risk factor for fatal arrhythmias and other cardiovascular complications. QT interval prolongation in patients on hemodialysis (HD) is not well understood.
Sho Sasaki +6 more
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Prevalence of the QT interval prolongation and its risk factors in hospitalized geriatric patients: findings of a single center cross-sectional study in Pakistan [PDF]
BMC GeriatricsBackground and objectives Geriatric inpatients are particularly susceptible to Torsades de Pointes (TdP) because they are usually polymorbid and often take QT-prolonging drugs.
Huma Tanveer +9 more
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Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
Scientific Reports, 2020 SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation.
Juan Jiménez-Jáimez +12 more
doaj +2 more sources
A case with a trend of QT interval prolongation due to the introduction of methadone to a pancreatic cancer patient on levofloxacin [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground As methadone can prevent the development of opioid resistance, it has application in alleviating cancer-related pain that proves challenging to manage with other opioids. QT interval prolongation is a serious side effect of methadone treatment,
Ryusuke Ouchi +9 more
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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development [PDF]
Cardiovascular Research, 2003 W REDFERN +9 more
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Development and Validation of a Risk Score to Predict QT Interval Prolongation in Hospitalized Patients [PDF]
Circulation. Cardiovascular Quality and Outcomes, 2013 James E. Tisdale +6 more
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