Results 11 to 20 of about 73,159 (323)

Predictive Analytics for Identification of Patients at Risk for QT Interval Prolongation – A Systematic Review [PDF]

Pharmacotherapy, 2018
Prolongation of the heart rate‐corrected QT (QTc) interval increases the risk for torsades de pointes (TdP), a potentially fatal arrhythmia. The likelihood of TdP is higher in patients with risk factors, which include female sex, older age, heart failure
Muensterman, Elena Tomaselli, Tisdale, James E.   +1 more
core   +2 more sources

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

Drug Safety, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +2 more sources

Effectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients [PDF]

Circulation. Cardiovascular Quality and Outcomes, 2014
BACKGROUND: We evaluated the effectiveness of a computer clinical decision support system (CDSS) for reducing the risk of QT interval prolongation in hospitalized patients.
Jaynes, Heather A., Kingery, Joanna R., Kovacs, Richard J., Mourad, Noha A., Overholser, Brian R., Tisdale, James E., Trujillo, Tate N.   +6 more
core   +2 more sources

Absence of relevant QT interval prolongation in not critically ill COVID-19 patients

Scientific Reports, 2020
SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation.
Juan Jiménez-Jáimez, Rosa Macías-Ruiz, Francisco Bermúdez-Jiménez, Ricardo Rubini-Costa, Jessica Ramírez-Taboada, Paula Isabel García Flores, Laura Gallo-Padilla, Juan Diego Mediavilla García, Concepción Morales García, Sara Moreno Suárez, Celia Fignani Molina, Miguel Álvarez López, Luis Tercedor   +12 more
doaj   +2 more sources

QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine [PDF]

Therapeutic Advances in Drug Safety, 2020
Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer’s disease (AD). This study aimed to evaluate evidence from the case report literature for an association between these ...
Katie Malone, Jules C. Hancox
openalex   +2 more sources

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development [PDF]

Cardiovascular Research, 2003
W REDFERN, Leif Carlsson, Alice Davis, W. G. Lynch, Ian C. Mackenzie, S PALETHORPE, Peter K. S. Siegl, I. Strang, A SULLIVAN, Russell Wallis   +9 more
openalex   +2 more sources

Assessment of QT Interval Prolongation Using Concentration-QT Modeling for Iptacopan, an Oral Complement Factor B Inhibitor, in Healthy Individuals. [PDF]

Clin Transl Sci
Kaetterer N, Kulmatycki K, Nidamarthy PK, McNamara E, Armas D, Jarugula V, Schmouder R.   +6 more
europepmc   +3 more sources

Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation. [PDF]

Int J Mol Sci, 2021
Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus ...
Baracaldo-Santamaría D, Llinás-Caballero K, Corso-Ramirez JM, Restrepo CM, Dominguez-Dominguez CA, Fonseca-Mendoza DJ, Calderon-Ospina CA.   +6 more
europepmc   +2 more sources

Syncope Linked to QT-Interval Prolongation and Global T-Wave Inversion: A Clinical Case of Acute Pulmonary Embolism. [PDF]

Ann Noninvasive Electrocardiol
Zhang XY, Li JX, Gao M, Li XQ, Zhang MY.
europepmc   +2 more sources

Incidence of QT interval prolongation during arsenic trioxide-based therapy in a sample of Iraqi adult patients with acute promyelocytic leukemia (a single-center experience)

Iraqi Journal of Hematology
BACKGROUND: Arsenic trioxide (ATO) regimen is now the standard of care for acute promyelocytic leukemia (APL). The complete remission and possible cure are reported to be 50%–80% of APL patients.
Aseel Abd Ul Sahib Hassan, Ali M. Jawad Almothaffar   +1 more
doaj   +2 more sources