Results 71 to 80 of about 55,959 (291)

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Life-Threatening QT Prolongation in a Preterm Infant

American Journal of Perinatology Reports, 2014
Introduction Temporary QT-interval prolongation following intracranial hemorrhage and hydrocephalus has been repeatedly reported in adults. Case We report a case of excessive QT prolongation with sudden bradycardia resulting in 2:1 ...
Christian Paech, Roman Gebauer, Matthias Knüpfer   +2 more
doaj   +1 more source

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

QT Interval Prolongation in Cirrhotic Cardiomyopathy

Research Reports in Clinical Cardiology, 2022
Amanuel Tadelle Department of Biomedical Sciences, Jimma University, Jimma City, EthiopiaCorrespondence: Amanuel Tadelle, Email newaman09@yahoo.com; amanuel.muluneh@ju.edu.etAbstract: The liver and the heart are related to each other in many aspects.
Tadelle A
doaj  

Quantitative Confounder Analysis of Electrocardiogram Signals in Cardiac Magnetic Resonance at 1.5, 3 and 7 T—Assessing Standardized Electrode Positions and Sequence Types—Towards Quality Assurance

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The electrocardiogram (ECG) used for gating in cardiac MRI may be compromised by multiple confounders inside the scanner bore. Purpose To quantify the influence of magnetic field strengths (1.5 T/3 T/7 T), standardized electrode positions, and imaging sequences on ECG signals used for gating. Study Type Prospective.
Richard Hickstein, Stephanie Wiesemann, Darian Viezzer, Denise Kleindienst, Teodora Chitiboi, Bogdan Andrei Gheorghita, Jens Wetzl, Thomas Hadler, Sebastian Dietrich, Sebastian Schmitter, Jeanette Schulz‐Menger   +10 more
wiley   +1 more source

QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias?

Cardiology Research and Practice, 2010
Introduction. Several studies show that hypoglycemia causes QT interval prolongation. The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia. Methods.
Toke Folke Christensen, Jette Randløv, Leif Engmann Kristensen, Ebbe Eldrup, Ole Kristian Hejlesen, Johannes Jan Struijk   +5 more
doaj   +1 more source

Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance

British Journal of Pharmacology, 2015
Evaluating whether a new medication prolongs QT intervals is a critical safety activity that is conducted in a sensitive animal model during non‐clinical drug development.
H. Vargas, A. Bass, J. Koerner, Sherri Matis-Mitchell, M. Pugsley, M. Skinner, M. Burnham, M. Bridgland-Taylor, S. Pettit, J. Valentin   +9 more
semanticscholar   +1 more source

Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review

JEADV Clinical Practice, EarlyView.
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson, Kara Hurley, Hannah Chaudhury, Lara Shehadeh, Cameron West   +4 more
wiley   +1 more source

Quadriceps, hamstring and patella tendon autografts for primary anterior cruciate ligament reconstruction demonstrate similar clinical outcomes, including graft failure, joint laxity and complications: A systematic review with meta‐analysis of randomised controlled trials

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Graft failure following anterior cruciate ligament reconstruction (ACLR) remains a significant challenge, driving discussion for optimal graft choice. Traditionally, hamstring tendon (HT) and bone‐patella tendon‐bone (BPTB) autografts have been favoured for ACLR. Recently, quadriceps tendon (QT) usage has increased.
Ty White, Matthew Castro, Lucas Antonio, Wayne Hing, Francois Tudor, Larissa Sattler   +5 more
wiley   +1 more source

Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia

Journal of Pharmacological Sciences, 2005
Potential utility of halothane-anesthetized guinea pigs for detecting drug-induced repolarization delay was analyzed in comparison with urethane-anesthesia (n = 4 for both groups).
Yasue Sakaguchi, Atsushi Sugiyama, Shuji Takao, Yasuki Akie, Akira Takahara, Keitaro Hashimoto   +5 more
doaj   +1 more source