Results 71 to 80 of about 73,159 (323)
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
JA Clinical Reports, 2017 We report that sevoflurane not only caused marked QTc interval prolongation but also increased transmural dispersion of repolarization in a patient with long QT syndrome 3 (LQT3). A 16-year-old male with LQT3 underwent a shoulder operation.
Atsuhiro Kitaura +6 more
doaj +1 more source
Evaluation of QTc before and after exercise testing in a population of patients with severe obesity: possible association with obstructive sleep apnoea [PDF]
, 2023 openObesity is associated with QT interval prolongation. Obesity is also associated with OSA (obstructive sleep apnoea). OSA as well is associated with prolongation of the QT interval.
CASARIN, MARTINO
core
A systematic review of the cardiotoxicity of methadone [PDF]
, 2015 Methadone is one of the most popular synthetic opioids in the world with some favorable properties making it useful both in the treatment of moderate to severe pain and for opioid addiction.
Alinejad, Samira +4 more
core +1 more source
Journal of Diabetes Investigation, 2017 A prolonged QT interval plays a causal role in life‐threatening arrhythmia, and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes.
Shunsuke Kobayashi +5 more
semanticscholar +1 more source
Case Reports in Cardiology, 2016 We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease.
John P. O’Laughlin +2 more
doaj +1 more source
QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects. [PDF]
PLoS ONE, 2014 The potassium voltage-gated channel KCNH2 is a well-known gene in which mutations induce familial QT interval prolongation. KCNH2 is suggested to be a risk gene for schizophrenia.
Kumiko Fujii +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, 2017 Aims Methadone is a widely used opioid agonist treatment associated with QT prolongation and torsades de pointes. We investigated the QT interval in patients treated with methadone or buprenorphine using continuous 12‐lead Holter recordings.
G. Isbister +5 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi +11 more
wiley +1 more source
Journal of Investigative Medicine High Impact Case Reports, 2020 Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and ...
B K Anupama MBBS +2 more
doaj +1 more source