Results 141 to 150 of about 55,181 (324)

Characterising QT interval prolongation in early clinical development: a case study with methadone [PDF]

, 2017
Recently, we have shown how pharmacokinetic-pharmacodynamic (PKPD) modelling can be used to assess the probability of QTc interval prolongation both in dogs and humans.
Danhof, M, Della Pasqua, O, Dubois, VFS
core  

A case of ventricular fibrillation as a consequence of capecitabine-induced secondary QT prolongation: A case report [PDF]

, 2017
Kazuto Hayasaka, Masateru Takigawa, Atsushi Takahashi, Taishi Kuwahara, Kenji Okubo, Yasuaki Tanaka, Toru Misawa, Masafumi Mizusawa, Yosuke Yamakami, Keisuke Kojima, Yuichiro Sagawa, Keiichi Hishikari, Kazuya Yamao, Emiko Nakashima, Jun Nakajima, Shigeki Kimura, Katsumasa Takagi, Hiroyuki Hikita, Mitsuaki Isobe   +18 more
openalex   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

QT prolongation with the use of ondansetron: A neglected and overlooked adverse effect

Journal of the Pakistan Medical Association
Ondansetron, commonly prescribed under the name ‘Onset’ in Pakistan, is one of the four FDA approved 5HT3 serotonin receptor antagonists for its antiemetic properties.
Dania Hussain
doaj   +1 more source

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

, 2015
Dong‐Seok Yim, Taegon Hong, Seunghoon Han, Jong-Tae Lee, Sangil Jeon, Gab-Jin Park, Wan‐Su Park, Kyoung Soo Lim, Jae‐Yong Chung, Kyung-Sang Yu   +9 more
openalex   +2 more sources

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Study of QT Prolongation in ECG in Type 2 Diabetes patients and its Correlation to HbA1c Levels

, 2023
Mugila Sinduja. S, Dr.Suneetha DK
openalex   +2 more sources

Population‐Based Study Found Low Risk of Misdiagnosing Long QT Syndrome as Breath‐Holding Spells in Swedish Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim An electrocardiogram is commonly recommended in breath‐holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath‐holding spells in a paediatric population in southern Sweden.
Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk   +3 more
wiley   +1 more source

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source