Results 31 to 40 of about 151,662 (178)

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Molecules, 2020
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities.
Raül Agut, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Alberto Marco   +7 more
doaj   +1 more source

A sequential multistep process for the fully mechanochemical, one-pot synthesis of the antiepileptic drug rufinamide

Green Chemistry Letters and Reviews, 2022
Mechanochemistry is a powerful tool to develop environmentally benign syntheses of active pharmaceutical ingredients. In this context, we report here the synthesis of the anti-epileptic agent rufinamide through a one-pot sequential multi-component ...
Jorge Gómez-Carpintero, Clara Cabrero, Juan Domingo Sánchez, Juan Francisco González, José Carlos Menéndez   +4 more
doaj   +1 more source

Synthetic scope and DFT analysis of the chiral binap–gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes

Beilstein Journal of Organic Chemistry, 2013
The 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(Sa)-Binap·AuTFA]2.
María Martín-Rodríguez, Luis M. Castelló, Carmen Nájera, José M. Sansano, Olatz Larrañaga, Abel de Cózar, Fernando P. Cossío   +6 more
doaj   +1 more source

Optimization of β-cyclodextrin-based extraction of antioxidant and anti-browning activities from thyme leaves by response surface methodology [PDF]

, 2018
Thyme (Thymus vulgaris) has been demonstrated to extend the shelf-life of food products, being also a potential source of bioactive compounds. The aim of this research was to optimize the ultrasound assisted extraction employing β-cyclodextrin aqueous ...
Buera, Maria del Pilar, dos Santos, Cristina, Favre, Leonardo Cristian, Lopez Fernandez, Maria Paula, Mazzobre, Maria Florencia   +4 more
core   +1 more source

Silicone-specific identification of trace polydimethylsiloxanes in wines with 2D-diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY-NMR)

BIO Web of Conferences, 2023
Present work stresses a novel analytical approach for increasing the specificity of standard NMR approaches for identifying polydimethylsiloxane (PDMS) and further silicone moieties in wines’ organic extracts, by including a second dimension that ...
Herbert-Pucheta José Enrique, Hernández-Rangel Álvaro Omar, Vargas-Díaz María Elena, Sánchez Karla Hernández, Zepeda-Vallejo Luis Gerardo, Jiménez-García Montserrat   +5 more
doaj   +1 more source

Stepwise On‐Surface Synthesis and Transformations of Two‐Dimensional Covalent Organic Frameworks by Controlled Thermal Stimuli

Advanced Materials, EarlyView.
The seminal transformation of a 2D‐COF (SURFCOF‐IMDEA1) into a 2D porous COF (SURFCOF‐IMDEA2) on Au(111) by a sequential C‐C coupling and ladderization triggered by thermal annealing steps at increasing temperatures is reported. Abstract The development of covalent organic frameworks (COFs) is currently a primary objective in materials science, taking ...
Ana Barragán, Elena Pérez‐Elvira, Diego J. Vicent, Marco Lozano, Diego Soler‐Polo, Koen Lauwaet, José M. Gallego, Rodolfo Miranda, José I. Urgel, Pavel Jelínek, Nazario Martín, David Écija   +11 more
wiley   +1 more source

Insecticidal Properties of Annonaceous Acetogenins and Their Analogues. Interaction with Lipid Membranes

Natural Product Communications, 2012
The interactions were studied by FTIR and DSC of the terminal lactone of annonaceous acetogenins (ACGs) and synthetic analogues, such as THF, with POPC bilayers, as well as the toxic effect produced by these compounds on Spodoptera frugiperda larvae. The
Lilian Di Toto Blessing, Juan Ramos, Sonia Diaz, Aída Ben Altabef, Alicia Bardón, Margarita Brovetto, Gustavo Seoane, Adriana Neske   +7 more
doaj   +1 more source

Cu(PPh₃)₃Br-Catalyzed Synthesis of New Paracetamol–1,2,3-Triazole Molecular Hybrids from Expired Commercial Tablets and Their In Silico Assessment to Study Their Pharmacological Properties

Medical Sciences Forum, 2022
The 1,2,3-Triazole ring has remarkable importance in medicinal chemistry due to its unique biological properties, such as metabolic stability and ability to form hydrogen bonds. Several biological activities had been reported for this structural nucleus,
Daniela Calderón Lamus, Carlos Eduardo Puerto Galvis, Vladimir Kouznetsov   +2 more
doaj   +1 more source

Counterintuitive Fluorescence Blue Shift in Symmetry Breaking Dicationic Bis(indolium) with Two‐Photon Absorption Properties for NIR Living Cell Imaging

Advanced Materials, EarlyView.
Highly water‐soluble dicationic bis(indolium) dyes have been prepared, showing excellent two‐photon absorption and light emission. Their fluorescence behavior discloses an unusual increasing blue shift with increasing solvent polarity, which, in parallel, is beneficial for enhanced detection in biological media.
Carlos Benitez‐Martin, Jose M. Marin‐Beloqui, Juan T. López Navarrete, Juan Casado, Francisco Najera, Ezequiel Perez‐Inestrosa   +5 more
wiley   +1 more source

Self‐Cooling Molecular Spin Qudits

Advanced Materials, EarlyView.
A material made of [GdEr] molecular dimers can encode a qudit and perform as a magnetic refrigerant. Microwave resonant pulses coherently manipulate its 16 spin states, while direct demagnetization measurements cool the material and a device down to temperatures below 1 K.
Elías Palacios, David Aguilà, David Gracia, Diamatoula Maniaki, Leoní A. Barrios, Alessandro Chiesa, Jesús I. Martínez, Valentin Novikov, Olivier Roubeau, Stefano Carretta, Marco Evangelisti, Guillem Aromí, Fernando Luis   +12 more
wiley   +1 more source